Results 11 to 20 of about 3,581 (198)

Systemic Toxicity of L-Mimosine in Rabbits: A Non-Rodent Model for Safety Assessment. [PDF]

J Appl Toxicol
ABSTRACT L‐mimosine is a non‐protein amino acid primarily found in the Mimosoideae subfamily, with high concentrations in Leucaena leucocephala and Mimosa pudica. These plants are widely used in both human and animal nutrition, as well as in phytotherapeutic applications. While the toxic effects of L‐mimosine have been extensively studied in ruminants,
Ferreira SM, Zapparoli H, Mussi CS, Maiorka PC, Andrade AFC, Górniak SL, Gotardo AT.   +6 more
europepmc   +2 more sources

A new spin on chemotaxonomy: Using non-proteogenic amino acids as a test case. [PDF]

Appl Plant Sci
Abstract Premise Specialized metabolites serve various roles for plants and humans. Unlike core metabolites, specialized metabolites are restricted to certain plant lineages; thus, in addition to their ecological functions, specialized metabolites can serve as diagnostic markers of plant lineages.
Gibson M, Thives Santos W, Oyler AR, Busta L, Schenck CA.   +4 more
europepmc   +2 more sources

Nuclear Import Defects Drive Cell Cycle Dysregulation in Neurodegeneration. [PDF]

Aging Cell
Overview of Dysregulated Cell Cycle Mechanisms in Neuronal Cells. A nuclear import block drives cell cycle re‐entry from G0, culminating in cell cycle arrest at G1/S. This cell cycle arrest is associated with activation of CKIs from the INK locus (p15, p16, p18, p19) and Cip/Kip (p21, p27) which act on specific CDK/Cyclin complexes.
Plessis-Belair J, Russo T, Riessland M, Sher RB.   +3 more
europepmc   +2 more sources

Mimosine Targets Serine Hydroxymethyltransferase [PDF]

Journal of Biological Chemistry, 1996
The plant amino acid, mimosine, is an extremely effective inhibitor of DNA replication in mammalian cells (Mosca, P. J., Dijkwel, P. A., and Hamlin, J. L. (1992) Mol. Cell. Biol. 12, 4375-4383). Mimosine appears to prevent the formation of replication forks at early-firing origins when delivered to mammalian cells approaching the G1/S boundary, and ...
H B, Lin, R, Falchetto, P J, Mosca, J, Shabanowitz, D F, Hunt, J L, Hamlin   +5 more
openaire   +2 more sources

Removal of Mimosine from Leucaena leucocephala (Lam.) de Wit Seeds to Increase Their Benefits as Nutraceuticals

Pharmaceutical Sciences and Research, 2020
The Leucaena leucocephala (Lam.) de Wit tree contains pharmacologically active compounds and can easily be found in abundant quantities. The utilization of this tree as a source of nutraceuticals would increase its value.
Sri Wardatun, Yahdiana Harahap, Abdul Mun’im, Fadlina Chany Saputri, Noorwati Sutandyo   +4 more
doaj   +1 more source

Synthesis of novel azo compounds containing 5(4H)-oxazolone ring as potent tyrosinase inhibitors [PDF]

, 2013
Six new azo dyes containing of 5(4H)-oxazolone ring were prepared by diazotization of 4-aminohippuric acid and coupling with N,N-dimethylaniline, 1-naphthol and 2-naphthol and condensation with 4-fluoro benzaldehyde or 4-trifluoromethoxy benzaldehyde ...
Abbasalipour, V., Fozooni, S., Hamidian, H., Namjou, M., Tagizadeh, R., Taheri, A.   +5 more
core   +1 more source

Phosphorylation of MCPH1 isoforms during mitosis followed by isoform‐specific degradation by APC/C‐CDH1 [PDF]

, 2019
Microcephalin‐1 (MCPH1) exists as 2 isoforms that regulate cyclin‐dependent kinase‐1 activation and chromosome condensation during mitosis, with MCPH1 mutations causing primary microcephaly.
Blain, Peter G., Dunn, Michael, Jowsey, Paul, Meyer, Stephanie K., Porter, Andrew, Vidier, Daniel S.   +5 more
core   +2 more sources

Nanosecond electric pulses penetrate the nucleus and enhance speckle formation [PDF]

, 2007
Nanosecond electric pulses generate nanopores in the interior membranes of cells and modulate cellular functions. Here, we used confocal microscopy and flow cytometry to observe Smith antigen antibody (Y12) binding to nuclear speckles, known as small ...
Beebe, S J, Chen, G, Chen, N, Deng, Y, Garner, A L, Jing, Y, Joshi, R P, Kolb, J F, Schoenbach, K H, Swanson, R J   +9 more
core   +1 more source

Mimosine concentration in Leucaena leucocephala under various environmental conditions

Tropical Grasslands-Forrajes Tropicales, 2019
Keynote paper presented at the International Leucaena Conference, 1‒3 November 2018, Brisbane, Queensland, Australia. Leucaena leucocephala (leucaena) is a multipurpose tropical tree-legume that is highly resistant to many biotic and abiotic stresses ...
Michael D.H. Honda, Dulal Borthakur
doaj   +1 more source

Generation of reactive oxygen species by hydroxypyridone compound/iron complexes

Redox Report, 2020
Objectives: Prooxidant properties of iron-binding hydroxypyridone compounds including deferiprone and mimosine were analyzed. Methods: Hydroxypyridone/iron-dependent production of reactive oxygen species was evidenced by the inactivation of aconitase ...
Keiko Murakami, Masataka Yoshino
doaj   +1 more source