Results 21 to 30 of about 3,581 (198)

Identification of murine phosphodiesterase 5A isoforms and their functional characterization in HL-1 cardiac cell line [PDF]

, 2017
Phosphodiesterase 5A (PDE5A) specifically degrades the ubiquitous second messenger cGMP and experimental and clinical data highlight its important role in cardiac diseases.
Barbagallo, Federica, Campolo, Federica, Cardarelli, Silvia, Cornacchione, Marisa, DE ARCANGELIS, Valeria, DI GRAZIA, Antonio, Gianfrilli, Daniele, Giorgi, Mauro, Isidori, Andrea, Lenzi, Andrea, Monaco, Lucia, Naro, Fabio, Pellegrini, Manuela, Zevini, Alessandra   +13 more
core   +1 more source

Mimosine Dipeptide Enantiomsers: Improved Inhibitors against Melanogenesis and Cyclooxygenase

Molecules, 2015
Melanogenesis plays an important role in the protection of skin against UV through production of melanin pigments, but abnormal accumulation of this pigment causes unaesthetic hyperpigmentation. Much effort is being made to develop effective depigmenting
Binh Cao Quan Nguyen, Shinkichi Tawata
doaj   +1 more source

The identification of dual protective agents against cisplatin-induced oto- and nephrotoxicity using the zebrafish model

eLife, 2020
Dose-limiting toxicities for cisplatin administration, including ototoxicity and nephrotoxicity, impact the clinical utility of this effective chemotherapy agent and lead to lifelong complications, particularly in pediatric cancer survivors.
Jaime N Wertman, Nicole Melong, Matthew R Stoyek, Olivia Piccolo, Stewart Langley, Benno Orr, Shelby L Steele, Babak Razaghi, Jason N Berman   +8 more
doaj   +1 more source

Mimosine functionalized gold nanoparticles (Mimo-AuNPs) suppress β-amyloid aggregation and neuronal toxicity

Bioactive Materials, 2021
Evidence suggests that increased level/aggregation of beta-amyloid (Aβ) peptides initiate neurodegeneration and subsequent development of Alzheimer's disease (AD). At present, there is no effective treatment for AD. In this study, we reported the effects
Bibin G. Anand, Qi Wu, Govindarajan Karthivashan, Kiran P. Shejale, Sara Amidian, Holger Wille, Satyabrata Kar   +6 more
doaj   +1 more source

DNA Breaks Induction by Mimosine

Zeitschrift für Naturforschung C, 2003
Abstract Mouse erythroleukemic F4 N cells were treated with mimosine, etoposide, Fe(II)-EDTA, and Cu(II) in the presence of ascorbate. DNA was isolated and subjected to agarose gel electrophoresis and the size and distribution of the DNA fragments produced by the agents were compared.
Emil, Mladenov, Boyka, Anachkova
openaire   +2 more sources

EVALUATION OF MIMOSINE TOXICITY IN GOAT AND BUFFALO ERYTHROCYTE SYSTEM IN VITRO [PDF]

Exploratory Animal and Medical Research, 2012
Dose and time dependent effect of mimosine in goat and buffalo erythrocyte system in vitro have been evaluated in the present study. The results obtained exhibit that mimosine induces hemolysis in both mode of studies with concomitant increase in ...
Arun Kumar Brahmachari
doaj  

Does the size of larval groups influence the effect of metabolic inhibitors on the development of Phormia regina (Diptera: Calliphoridae) larvae?

European Journal of Entomology, 2002
A series of experiments were conducted to compare the susceptibility of P. regina larvae reared in isolation or in groups to the effects of diet-borne metabolic inhibitors: chlorogenic acid (CGA) and mimosine.
Paul W.C. GREEN, Monique S.J. SIMMONDS, Wally M. BLANEY   +2 more
doaj   +1 more source

Dwarf koa (Desmanthus virgatus) [PDF]

, 2015
This is the final version. It was first published by BioMed Central at http://www.biomedcentral.com/1471-2164/16/473.Background: Mobile elements are active in the human genome, both in the germline and cancers, where they can\ud mutate driver genes.\ud ...
Edwards, Paul A. W., Eldridge, Matthew D., Fitzgerald, Rebecca C., OCCAMs Consortium, Paterson, Anna L., Tavar?, Simon, Weaver, Jamie M. J.   +6 more
core   +4 more sources

Inhibition of activity of collagen degradation in cartilage of patients with osteoarthrosis byactivation of glycolysis

Остеопороз и остеопатии, 2011
Aim. To study the effect of glycolysis activators deferrioxamine (DFO), CoCl2, V(SO4)2 and mimosine on collagen cleavage activity by collagenase in osteoarthritic (OA) articular cartilage explants. Materials and methods.
E. V. Chetina, E. V. Chetina
doaj   +1 more source

Effect of Feeding Different Cultivars of Leucaena leucocephala on Rumen-Based in vitro Anaerobic Fermentations

Proceedings, 2020
The leguminous forage shrub, Leucaena leucocephala, is one of the few nutritional options available to significantly improve beef productivity in Northern Australia.
Diane Ouwerkerk, Anita Maguire, Jenny Gravel, Cathy Minchin, Michael Gravel, Athol Klieve, Ros Gilbert   +6 more
doaj   +1 more source