Beyond Hemodynamics: Uremic Toxins, Post-Translational Modifications, and Inflammatory-Metabolic Remodeling in Uremic Cardiomyopathy. [PDF]
Parnasa E +5 more
europepmc +1 more source
Klotho Deficiency Impairs Distal Potassium Homeostasis Through mTORC1‐Dependent Suppression of ROMK
ABSTRACT Aim Hyperkalemia is prevalent in the elderly, and underlying molecular mechanisms remain incompletely understood. We hypothesized that Klotho deficiency, a feature of aging, impairs renal potassium homeostasis and contributes to hyperkalemia. Methods Klotho heterozygous knockout (KLhet) mice, characterized by reduced Klotho levels, were used ...
Wakako Kawarazaki +6 more
wiley +1 more source
Efficacy of finerenone in reducing proteinuria in diabetic kidney disease on dapagliflozin and telmisartan: A disease-modifying approach. [PDF]
Jose A +3 more
europepmc +1 more source
A Ten Year Overview of Adrenal Vein Sampling in Croatia: Insights and Outcomes
ABSTRACT Background Adrenal vein sampling (AVS) is the gold standard for subtype differentiation in primary aldosteronism (PA), yet it remains technically demanding and resource intensive. However, data on long‐term performance, learning curves, and concordance with imaging in real‐world clinical practice are limited.
Karin Zibar Tomsic +4 more
wiley +1 more source
Redefining Therapeutic Targets in Hypertension and Cardiometabolic Syndrome. [PDF]
Masenga SK, Kirabo A.
europepmc +1 more source
ABSTRACT Aims The association between glucagon‐like peptide‐1 receptor agonist (GLP‐1RA) use and the development of bowel obstruction/ileus remains unclear, and evidence for specific bowel obstruction/ileus subtypes remains limited. We examined the association between GLP‐1RA use and the incidence of bowel obstruction/ileus subtypes across different ...
Yuichiro Matsuo +3 more
wiley +1 more source
Emerging Strategies for Cardio-Renal Protection Beyond RAAS Blockade: <i>Emphasis on Non-diabetic CKD and Resistant Hypertension</i>. [PDF]
Alrashidi FS.
europepmc +1 more source
Abstract Background Adrenal crisis is a life‐threatening emergency. Despite preventive strategies, previous reports suggest increasing incidence and substantial mortality, but robust validated data are limited. Objective To assess temporal trends in adrenal crisis incidence and identify associated risk factors.
Ann‐Elin Meling Stokland +29 more
wiley +1 more source
Serum Potassium and Mineralocorticoid Receptor Antagonists As Modifiers of Atrial Arrhythmia Recurrence After Catheter Ablation for Atrial Fibrillation: A Narrative Review With Systematic Search and Mechanistic Synthesis. [PDF]
Tomita S, Kishi T.
europepmc +1 more source

