Results 181 to 190 of about 46,446 (218)

SGLT2i in heart failure: Cardiorenal mechanisms, clinical evidence and translational perspectives

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
SGLT2 inhibitors improve heart failure outcomes through integrated cardiorenal mechanisms. In the kidney, they reduce glucose and sodium reabsorption, promoting natriuresis, osmotic diuresis and renal protection. In the heart, they enhance myocardial energetics, reduce inflammation, oxidative stress, fibrosis and adverse remodelling, resulting in fewer
Jelica Grujic‐Milanovic, Jovana Rajkovic, Radmila Novakovic, Javad Sharifi‐Rad, Daniela Calina   +4 more
wiley   +1 more source

Upregulated Renal Mineralocorticoid Receptor and 11β-Hydroxysteroid Dehydrogenase Type 2 Are Associated with K⁺ Retention During MR Antagonism in Female Spontaneously Hypertensive Rats. [PDF]

Int J Mol Sci
Baranovskaya I, Bilous I, Alexander S, Tubalinal B, Cherezova A, Buncha V, Fomin M, Gomez-Sanchez C, Mamenko M.   +8 more
europepmc   +1 more source

Vaporised etomidate (“space oil”) misuse: A narrative review

Hong Kong Journal of Emergency Medicine, Volume 33, Issue 5, October 2026.
Abstract Background Etomidate, a well‐established intravenous induction agent valued for haemodynamic stability, has emerged as a recreational drug via e‐cigarette vaping (“space oil”), particularly in Asia, including Hong Kong, prompting regulatory controls amid rising emergency presentations.
Sui Wa Au, Yu‐Yeung Yip
wiley   +1 more source

Mineralocorticoid Receptor Antagonists for Liver Fibrosis: Potential Mechanisms and Research Progress. [PDF]

J Clin Transl Hepatol
Zheng H, Feng Y.
europepmc   +1 more source

Molecular and Cellular Underpinnings of Primary Hypertension: An Integrative Mechanistic Framework

Journal of Cellular Physiology, Volume 241, Issue 10, October 2026.
ABSTRACT Hypertension is a highly prevalent clinical condition and a major contributor to global cardiovascular morbidity and mortality. Despite extensive research, its complex and multifaceted pathogenesis is yet to be fully elucidated. This paper explores the updated understanding of primary hypertension as a systemic disorder rather than an isolated
Dima Nasrallah, Alaa Abdelhamid, Omar Tluli, Yaman Al‐Haneedi, Mera Abu Hussien, Ali H. Eid   +5 more
wiley   +1 more source

Nonsteroidal Mineralocorticoid Receptor Antagonists in Heart Failure: Mechanistic Basis, Clinical Evidence, and Therapeutic Integration. [PDF]

Drugs Drug Candidates
Al-Horani RA, Goyal N.
europepmc   +1 more source

Five‐Year CT‐Based Skeletal Muscle Decline Curves in Cirrhosis According to Liver Functional Reserve and Routinely Available Clinical Factors

JGH Open, Volume 10, Issue 10, October 2026.
ABSTRACT Background Sarcopenia is common in cirrhosis and is associated with poor outcomes. We aimed to identify factors associated with longitudinal skeletal muscle loss and to explore estimation of future L3 skeletal muscle index (L3‐SMI) using routinely available clinical variables. Methods This retrospective longitudinal study included 175 patients
Suguru Miida, Hiroteru Kamimura, Hitoshi Yoshiji, Masahito Shimizu, Takumi Kawaguchi, Tetsuya Tsuji, Saori Endo, Hiroki Natsui, Hiroki Maruyama, Hiroyuki Abe, Tadashi Namisaki, Takao Miwa, Dan Nakano, Michiyuki Kawakami, Shuji Terai   +14 more
wiley   +1 more source

Cardiac Resynchronization as an Enabler of ARNI Efficacy: Insights From a Real‐World Cohort

Journal of Arrhythmia, Volume 42, Issue 5, October 2026.
CRT provides the mechanical substrate that enables sacubitril/valsartan to maximize reverse remodeling. In this real‐world cohort, ARNI therapy was associated with greater improvement in left ventricular function and fewer clinically validated device‐detected HF events, particularly among CRT responders, supporting a synergistic interaction between ...
Amato Santoro, Laura Spaccaterra, Maurizio Collantoni, Claudia Baiocchi, Benedetta Maria Natali, Stefano Lunghetti, Antonio Pagliaro, Niccolò Manetti, Francesco Morrone, Massimo Fineschi, Alberto Palazzuoli   +10 more
wiley   +1 more source