Results 21 to 30 of about 93,504 (350)
American Journal of Kidney Diseases, 2022 Mineralocorticoid receptor (MR) activation is involved in propagating kidney injury, inflammation, and fibrosis and in the progression of chronic kidney disease (CKD).
Murray Epstein +4 more
semanticscholar +1 more source
Novel non‐steroidal mineralocorticoid receptor antagonists in cardiorenal disease
British Journal of Pharmacology, 2021 Mineralocorticoid receptor antagonists (MRAs) are key agents in guideline‐oriented drug therapy for cardiovascular diseases such as chronic heart failure with reduced ejection fraction and resistant hypertension.
U. Kintscher, G. Bakris, P. Kolkhof
semanticscholar +1 more source
Journal of Veterinary Internal Medicine, 2023 Background Primary hypoadrenocorticism (PH) is rare in cats and knowledge about treatment is sparse. Objective To describe cats with PH with a focus on long‐term treatment. Animals Eleven cats with naturally occurring PH.
Nadja S. Sieber‐Ruckstuhl +8 more
doaj +1 more source
Heterogeneous natural history of Addison’s disease: mineralocorticoid deficiency may predominate
Endocrine Connections, 2022 Autoimmune Addison’s disease (AAD) is defined as primary adrenal insufficiency due to immune-mediated destruction of the adrenal cortex. This destruction of steroid-producing cells has historically been thought of as an irreversible process, with linear ...
Sophie Howarth +3 more
doaj +1 more source
European Journal of Heart Failure, 2021 Whether to continue or stop mineralocorticoid receptor antagonists (MRA) after an episode of hyperkalaemia is a challenge in clinical practice. While stopping MRA may prevent recurrent hyperkalaemias, it deprives patients of their cardioprotection.
Marco Trevisan +8 more
semanticscholar +1 more source
Steroidal and non-steroidal mineralocorticoid receptor antagonists in cardiorenal medicine
European Heart Journal, 2020 This review covers the last 80 years of remarkable progress in the development of mineralocorticoid receptor (MR) antagonists (MRAs) from synthesis of the first mineralocorticoid to trials of nonsteroidal MRAs.
R. Agarwal +6 more
semanticscholar +1 more source
T-Cell Mineralocorticoid Receptor Controls Blood Pressure by Regulating Interferon-Gamma
Circulation Research, 2017 Chao Li, Xu Liu, Zichun Hua
exaly +2 more sources
New Perspectives on Sex Steroid and Mineralocorticoid Receptor Signaling in Cardiac Ischemic Injury
Frontiers in Physiology, 2022 The global burden of ischemic heart disease is burgeoning for both men and women. Although advances have been made, the need for new sex-specific therapies targeting key differences in cardiovascular disease outcomes in men and women remains ...
Laura A. Bienvenu +7 more
doaj +1 more source
Pharmacology Research & Perspectives, 2022 Aldosterone exerts some of its effects not by binding to mineralocorticoid receptors, but rather by acting via G protein‐coupled estrogen receptors (GPER).
Qingming Ding +5 more
doaj +1 more source
The role of aldosterone in the pathogenesis of diabetic retinopathy
Frontiers in Endocrinology, 2023 Aldosterone, as a mineralocorticoid of adrenal origin, has effects that are not limited to the urinary tract. As an important regulator in Vasoactive hormone pathways, aldosterone may play an effect in the pathogenesis of diabetic retinopathy (DR ...
Kangcheng Liu +8 more
doaj +1 more source