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Evolution of the Mineralocorticoid Receptor
2019The mineralocorticoid receptor (MR) and its kin, the glucocorticoid receptor (GR) evolved from an ancestral corticoid receptor (CR) in a cyclostome (jawless fish) through gene duplication and divergence. Distinct MR and GR orthologs first appear in cartilaginous fishes, such as sharks, skates, rays and chimaeras.
Michael E, Baker, Yoshinao, Katsu
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Mineralocorticoid Receptors: Distribution and Activation
Heart Failure Reviews, 2005Mineralocorticoid receptors (MR) bind both mineralocorticoids and glucocorticoids with high affinity (deoxycorticosterone = corticosterone >/= aldosterone = cortisol), and are found in both Na(+) transporting epithelia (e.g. kidney, colon) and nonepithelial tissues (e.g. heart, brain).
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The role of mineralocorticoid receptor activation in kidney inflammation and fibrosis
Kidney International Supplements, 2022James M Luther
exaly
Nonepithelial mineralocorticoid receptor activation as a determinant of kidney disease
Kidney International Supplements, 2022Toshifumi Nakamura +2 more
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Brain Mineralocorticoid Receptor Functiona
Annals of the New York Academy of Sciences, 1994E R, de Kloet +3 more
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Cyproheptadine and Mineralocorticoid Receptors
New England Journal of Medicine, 1982ARMANINI, DECIO, KARBOWIAK I, FUNDER J.
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