Results 231 to 240 of about 1,369,571 (283)

Comparative effectiveness of finerenone versus steroidal mineralocorticoid receptor antagonists on sepsis-induced cardiomyopathy in patients with diabetic kidney disease: a real-world cohort study. [PDF]

Front Pharmacol
Wu JY, Lee KW, Huang SC, Chang HY, Lin YM.   +4 more
europepmc   +1 more source

Correction: The mineralocorticoid receptor antagonist finerenone enhances cardiovascular recovery upon food intake normalization in obese mice. [PDF]

Cardiovasc Diabetol
Monmirel-Fauconnier M, Pieronne-Deperrois M, Bonnard B, Frimat C, Linghui K, Dheasmhunaigh AN, Nicol L, Morchid S, Renet S, Dumesnil A, Richard V, Fève B, Jaisser F, Boulkroun S, Mulder P, Ouvrard-Pascaud A.   +15 more
europepmc   +1 more source

Mineralocorticoid receptor antagonists in dialysis patients after ACHIEVE and ALCHEMIST: updated systematic review and meta-analysis of 14 randomized trials. [PDF]

Ren Fail
Zhu Y, Li J, Huang Z, Qiu F.
europepmc   +1 more source

Review of Hyperkalemia Profile for Mineralocorticoid Receptor Antagonist in Patients with Chronic Kidney Disease and Type 2 Diabetes.

Cardiorenal Med
Kendrick JB, Dixon AM.
europepmc   +1 more source

Divergent Renal Benefits of Sodium-Glucose Cotransporter-2 Inhibitors and Mineralocorticoid Receptor Antagonists in Nondiabetic Kidney Disease.

Kidney Blood Press Res
Chen R, Zhang J, Chen J, Xie T, Xu Y, Hu Z, Chen J.   +6 more
europepmc   +1 more source

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The Multifaceted Mineralocorticoid Receptor

Comprehensive Physiology, 2014
Abstract The primary adrenal cortical steroid hormones, aldosterone, and the glucocorticoids cortisol and corticosterone, act through the structurally similar mineralocorticoid (MR) and glucocorticoid receptors (GRs). Aldosterone is crucial for fluid, electrolyte, and hemodynamic homeostasis and tissue repair; the
Elise, Gomez-Sanchez, Celso E, Gomez-Sanchez   +1 more
openaire   +2 more sources

Evolution of the Mineralocorticoid Receptor

2019
The mineralocorticoid receptor (MR) and its kin, the glucocorticoid receptor (GR) evolved from an ancestral corticoid receptor (CR) in a cyclostome (jawless fish) through gene duplication and divergence. Distinct MR and GR orthologs first appear in cartilaginous fishes, such as sharks, skates, rays and chimaeras.
Michael E, Baker, Yoshinao, Katsu
openaire   +2 more sources

The Brain Mineralocorticoid Receptor: Greedy for Ligand, Mysterious in Function

European Journal of Pharmacology, 2000
Glucocorticoids exert their regulatory effects on the hypothalamic-pituitary-adrenocortical axis via two types of corticosteroid receptors: the glucocorticoid receptor and the mineralocorticoid receptor.
Florian Holsboer, Johannes M. Reul, A C Linthorst   +2 more
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Aldosterone, Mineralocorticoid Receptor and the Metabolic Syndrome:Role of the Mineralocorticoid Receptor Antagonists

Current Vascular Pharmacology, 2012
Several lines of evidence suggest a detrimental effect of aldosterone excess on the development of metabolic alterations. Glucose metabolism derangements due to aldosterone action are frequently observed not only in patients with primary aldosteronism but also in patients with obesity. A contribution to the hyperaldosteronism observed in obese subjects
Ronconi, Vanessa, Turchi, Federica, Appolloni, Gloria, di Tizio, Valentina, BOSCARO, MARCO, Giacchetti, Gilberta   +5 more
openaire   +2 more sources

Mineralocorticoid receptors and hypertension

The Journal of Steroid Biochemistry and Molecular Biology, 1995
Mineralocorticoid receptors (MR) have equal affinity for the mineralocorticoid aldosterone, and the physiological glucocorticoids cortisol and corticosterone. In epithelial tissues in vivo, MR are protected against glucocorticoid occupancy by the enzyme 11 beta-hydroxysteroid dehydrogenase, allowing access by the lower circulating levels of the ...
openaire   +2 more sources