Results 211 to 220 of about 1,369,571 (283)

The non-steroidal mineralocorticoid receptor blocker esaxerenone reduces glomerular hyperfiltration and albuminuria. [PDF]

Nephrol Dial Transplant
Tatsugawa R, Kidokoro K, Iwakura T, Hirano A, Kajimoto E, Takasu M, Wada M, Kitao H, Wada Y, Gyarmati G, Kishi S, Nagasu H, Cherney DZI, Peti-Peterdi J, Sasaki T, Kashihara N.   +15 more
europepmc   +1 more source

Long‐term effects of tofogliflozin on renal function in patients with type 2 diabetes: A retrospective multicenter study

Journal of Diabetes Investigation, Volume 17, Issue 11, Page 1917-1926, November 2026.
ABSTRACT Aims To investigate the long‐term renal effects of tofogliflozin, with the shortest half‐life among sodium–glucose cotransporter 2 inhibitors, in real‐world clinical practice. Materials and methods We retrospectively enrolled patients with type 2 diabetes mellitus treated at three affiliated hospitals between January 2015 and May 2024.
Natsuko Shinagawa, Hiroshi Okada, Junya Hironaka, Shinta Yamamoto, Mari Yoneda, Sayaka Kawai, Yuto Saijyo, Tomoya Katayama, Hanako Nakajima, Akio Kishi, Noriyuki Kitagawa, Naoko Nakanishi, Masahide Hamaguchi, Michiaki Fukui   +13 more
wiley   +1 more source

Nonsteroidal Mineralocorticoid Receptor Antagonists in Heart Failure: Mechanistic Basis, Clinical Evidence, and Therapeutic Integration. [PDF]

Drugs Drug Candidates
Al-Horani RA, Goyal N.
europepmc   +1 more source

Risk and outcomes of adrenal crisis in primary adrenal insufficiency: Evidence from a 24‐year nationwide cohort study

Journal of Internal Medicine, Volume 300, Issue 5, Page 675-688, November 2026.
Abstract Background Adrenal crisis is a life‐threatening emergency. Despite preventive strategies, previous reports suggest increasing incidence and substantial mortality, but robust validated data are limited. Objective To assess temporal trends in adrenal crisis incidence and identify associated risk factors.
Ann‐Elin Meling Stokland, Lars Breivik, Ingvild Dalen, Sandra Dis Steintorsdottir, Simon Kildal, Ingrid Nermoen, Kari Lima, Margrethe Svendsen, Åse Bjorvatn Sævik, Aleksandra Debowska, Stina Therese Sollid, Daniel Hannisdal, Trine Elisabeth Finnes, Agnes Judit Horvath, Elin Korsgaard, Hallvard Singsås, Bjørn O. Åsvold, Maria Eriksson Steigen, Sigrid Blika, Petya Milova, Anders Svare, Anja Fog Heen, Lene Katrine Bjerke, Marianne Stedje, Siri Carlsen, Bjørn Gunnar Nedrebø, Anders Palmstrøm Jørgensen, Grethe Å. Ueland, Marianne Øksnes, Eystein Sverre Husebye   +29 more
wiley   +1 more source

Non-steroidal mineralocorticoid receptor antagonists in non-diabetic kidney disease: a narrative review of mechanisms and clinical advances. [PDF]

BMC Nephrol
Luo F, Hu J, Fang H, Li X, Zhu C, Bao Z.
europepmc   +1 more source

Evaluation of thyroglobulin autoantibodies in dogs at the time of diagnosis of hypoadrenocorticism and during treatment

Veterinary Record, Volume 199, Issue 8, Page e350-e358, 17/24 October 2026.
Abstract Background Autoimmune thyroiditis (AIT) may occur more frequently in dogs with hypoadrenocorticism (HA) than previously recognised. The objective of this study was to determine the presence of thyroglobulin autoantibodies (TgAAs) in dogs with HA.
Christin Emming, Sina Strey, Ina Leiter, Reinhard Mischke, Holger Volk, Marion Schmicke, Johanna Rieder   +6 more
wiley   +1 more source

PRO/CON debate: nonsteroidal versus steroidal mineralocorticoid receptor antagonists in chronic kidney disease: progress, pragmatism, and remaining uncertainties. [PDF]

Clin Kidney J
Agarwal R, Vogt L, Floege J, Zoccali C.
europepmc   +1 more source

Multitarget Drug Design for Cardiovascular Disease: Bridging Chemistry and Medicine

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
Many pathophysiological pathways associated with cardiovascular diseases involve multiple drug targets. This article reviews recent advances in the development of pharmacological compounds capable of simultaneously modulating multiple mechanisms. Multitarget drugs offer a promising therapeutic approach for complex cardiovascular disorders, including ...
Gyuzel Y. Mitronova, Vladimir N. Belov, Constanze Schmidt, Stephan E. Lehnart   +3 more
wiley   +1 more source

Interpreting the Association Between Diuretic Intensity Score and Mortality: The Potential Roles of Diuretic Responsiveness and Mineralocorticoid Receptor Antagonist Therapy. [PDF]

Clin Cardiol
Imamura T.
europepmc   +1 more source

Abnormal activation of the mineralocorticoid receptor in the aldosterone-sensitive distal nephron contributes to fructose-induced salt-sensitive hypertension. [PDF]

Am J Physiol Renal Physiol
Zhang R, Kim N, Shi S, Jadhav DA, Brostek A, Forester BR, Shukla R, Qu C, Kramer BK, Moss FJ, Garvin JL, Kleyman TR, Gonzalez-Vicente A.   +12 more
europepmc   +1 more source