Results 211 to 220 of about 35,682 (244)
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Mineralocorticoid Receptors in the Rat Lung*
Endocrinology, 1981In lung cytosol from adrenalectomized rats, tritiated aldosterone binds to two classes of limited capacity sites with affinities (Kd at 37 C) of 0.7 and 80 nM. The predominant binding species sediments at approximately 9S on sucrose density gradients in low ionic strength, molybdate-containing buffer.
Z, Krozowski, J W, Funder
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Glucocorticoid and mineralocorticoid receptors for aldosterone
Journal of Steroid Biochemistry, 1972Abstract Specific binding of aldosterone and dexamethasone by rat kidney and hepatoma tissue culture (HTC) cell cytosol has been studied. In cytosol of HTC cells, aldosterone and dexamethasone bind to a single class of sites with affinities that correspond with their potencies as inducers of tyrosine aminotransferase.
G, Rousseau +4 more
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Mechanisms of Mineralocorticoid Receptor Signaling
2019The cellular response to aldosterone is mediated by the mineralocorticoid receptor (MR). This response is best characterized in the renal epithelia with control of sodium and water homeostasis. However, the MR binds more than one ligand and has wide tissue distribution with multiple roles in cardiovascular function, immune cell signaling, neuronal fate
Peter J, Fuller +2 more
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Reconsidering the Roles of the Mineralocorticoid Receptor
Hypertension, 2009Translational research is usually taken to mean the application of laboratory discovery to clinical practice. Like languages or enzymes, however, translation is a 2-way street, and in the field of aldosterone and mineralocorticoid receptors (MR), there are a number of examples where clinical studies have prompted reconsideration of the basic biology ...
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Mineralocorticoid Receptors: Distribution and Activation
Heart Failure Reviews, 2005Mineralocorticoid receptors (MR) bind both mineralocorticoids and glucocorticoids with high affinity (deoxycorticosterone = corticosterone >/= aldosterone = cortisol), and are found in both Na(+) transporting epithelia (e.g. kidney, colon) and nonepithelial tissues (e.g. heart, brain).
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Cyproheptadine and Mineralocorticoid Receptors
New England Journal of Medicine, 1982ARMANINI, DECIO, KARBOWIAK I, FUNDER J.
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The role of mineralocorticoid receptor activation in kidney inflammation and fibrosis
Kidney International Supplements, 2022Luther Jm, Agnes Fogo
exaly
Nonepithelial mineralocorticoid receptor activation as a determinant of kidney disease
Kidney International Supplements, 2022Frédéric Jaisser +2 more
exaly