Results 201 to 210 of about 1,369,571 (283)

Renin‐Angiotensin Signaling and Vascular Function: Insights into Health and Disease

Acta Physiologica, Volume 242, Issue 11, November 2026.
ABSTRACT The renin‐angiotensin system (RAS) is an essential regulator of vascular structure and function, and dysregulation of angiotensin II (Ang II) signaling plays a critical role in the development of hypertension and associated vascular complications.
Giovanni Bertoldi, Swapnil K. Sonkusare
wiley   +1 more source

Mechanisms for Mineralocorticoid-Driven Age-Related Hypertension: Potential Therapeutic Role of Mineralocorticoid Receptor Antagonists and Aldosterone Synthase Inhibitors. [PDF]

Circ Res
Golec S, Vaidya A, Pitt B, Jaffe IZ.
europepmc   +1 more source

Klotho Deficiency Impairs Distal Potassium Homeostasis Through mTORC1‐Dependent Suppression of ROMK

Acta Physiologica, Volume 242, Issue 11, November 2026.
ABSTRACT Aim Hyperkalemia is prevalent in the elderly, and underlying molecular mechanisms remain incompletely understood. We hypothesized that Klotho deficiency, a feature of aging, impairs renal potassium homeostasis and contributes to hyperkalemia. Methods Klotho heterozygous knockout (KLhet) mice, characterized by reduced Klotho levels, were used ...
Wakako Kawarazaki, Nobuhiro Ayuzawa, Mitsuhiro Nishimoto, Daigoro Hirohama, Kohei Ueda, Takeshi Marumo, Toshiro Fujita   +6 more
wiley   +1 more source

Mineralocorticoid receptor antagonists: Efficacy and safety in chronic kidney disease. [PDF]

Diabetes Obes Metab
Mottl AK, Khunti K, Mathieu C.
europepmc   +1 more source

A Ten Year Overview of Adrenal Vein Sampling in Croatia: Insights and Outcomes

Clinical Endocrinology, Volume 105, Issue 5, Page 533-539, November 2026.
ABSTRACT Background Adrenal vein sampling (AVS) is the gold standard for subtype differentiation in primary aldosteronism (PA), yet it remains technically demanding and resource intensive. However, data on long‐term performance, learning curves, and concordance with imaging in real‐world clinical practice are limited.
Karin Zibar Tomsic, Ana Marija Alduk, Elvira Kresic, Ivana Kraljevic, Darko Kastelan   +4 more
wiley   +1 more source

Mineralocorticoid receptor antagonists for the treatment of heart failure and kidney disease: a state-of-the-art review. [PDF]

Heart Fail Rev
Van Spall HGC, Vardeny O.
europepmc   +1 more source

Bowel Obstruction/Ileus Associated With the Use of Glucagon‐Like Peptide‐1 Receptor Agonists: A Nationwide Database Study

Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 9941-9954, November 2026.
ABSTRACT Aims The association between glucagon‐like peptide‐1 receptor agonist (GLP‐1RA) use and the development of bowel obstruction/ileus remains unclear, and evidence for specific bowel obstruction/ileus subtypes remains limited. We examined the association between GLP‐1RA use and the incidence of bowel obstruction/ileus subtypes across different ...
Yuichiro Matsuo, Akira Okada, Takashi Sakamoto, Hideo Yasunaga   +3 more
wiley   +1 more source

Recombinant human Thymosin β4 ameliorates experimental colitis and intestinal fibrosis through suppression of mineralocorticoid receptor signaling. [PDF]

Mol Biomed
Zhao TR, Hu EB, Wang MW, Zhai YF, Mao YY, Hou WY, Zhang XZ, Liu ZZ, Hou SL, Xu JJ, Yu R.   +10 more
europepmc   +1 more source

Effects of esaxerenone add‐on therapy versus angiotensin II receptor blocker dose escalation on albuminuria and blood pressure in hypertensive patients with type 2 diabetes: An exploratory randomized study

Journal of Diabetes Investigation, Volume 17, Issue 11, Page 1956-1966, November 2026.
ABSTRACT Aims Residual albuminuria remains a major clinical challenge in patients with type 2 diabetes mellitus and hypertension despite renin–angiotensin system inhibitor therapy. Esaxerenone, a selective nonsteroidal mineralocorticoid receptor antagonist, reduces albuminuria; however, its effects on oxidative stress remain unclear.
Makoto Ohara, Takemasa Omachi, Nobuaki Takehana, Tomoki Fujikawa, Naoya Osaka, Shunichiro Irie, Michishige Terasaki, Yusaku Mori, Takanori Matsui, Sho‐ichi Yamagishi   +9 more
wiley   +1 more source

Temporal distribution of acute kidney injury–related hospitalizations after initiation of sodium–glucose cotransporter 2 inhibitors: A nationwide claims database analysis in older adults with an independent complementary single‐center eGFR analysis

Journal of Diabetes Investigation, Volume 17, Issue 11, Page 1904-1916, November 2026.
Among 190 older adults who experienced AKI‐related hospitalization after SGLT2 inhibitor initiation, 31.1% were hospitalized within 30 days. In an independent single‐center cohort, sustained early eGFR decline was associated with older age and use of one or two triple‐whammy‐related drug classes.
Kazuya Hiura, Ayana Tatsuno, Yamato Noto, Ryosuke Wakamatsu, Masayuki Sakunami, Ryu Kobayashi, Miki Yamashita   +6 more
wiley   +1 more source