Results 191 to 200 of about 1,369,571 (283)

A comparative real-world analysis of finerenone and steroidal mineralocorticoid receptor antagonists in patients with chronic kidney disease. [PDF]

Front Pharmacol
Vetrano D, Cianciolo G, Barbuto S, Ribichini D, Berti S, Mistretta A, Ginesi M, Millar PT, Grimaldi A, Vischini G, Poluzzi E, Pagotto U, La Manna G, Capelli I.   +13 more
europepmc   +1 more source

In Silico Clinical Trials in Drug Development: Virtual Patients, Applications, and Regulatory Convergence

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1181-1194, November 2026.
Conventional clinical trials remain the benchmark for evaluating therapeutic safety and efficacy, yet they are constrained by escalating costs, withdrawal over the extended follow‐up periods, recruitment difficulties, ethical limits, and a restricted ability to characterize heterogeneous populations.
Maximilian Balmus, Sheng‐Ya Wang, Edward W. G. Ashton, Rosie K. Barrows, Molly Monks, Yuzhang Ge, Arthur Lefebvre, Steven A. Niederer   +7 more
wiley   +1 more source

Mineralocorticoid receptor antagonists and mortality in hypertension: a systematic review and meta-analysis. [PDF]

J Hypertens
Teh JW, Comerford G, Surlis G, Curneen J, Krewer F, Smyth A, Lappin D, Mcevoy JW, Dennedy MC, Judge C.   +9 more
europepmc   +1 more source

Toward a digital urinary biopsy for early risk stratification in diabetic kidney disease: Anchoring shed cells, vesicles, and cell‐free DNA to spatial kidney cell states

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
In diabetic kidney disease, one urine specimen carries shed cells, extracellular vesicles and cell‐free DNA released along the whole nephron. Reading all three against spatial kidney atlases is proposed as a testable route to cell‐resolved, non‐invasive risk stratification, and the clinical outputs shown are not yet demonstrated.
Juan Wu, Ping Sheng, Ying Lu, Ke Chen
wiley   +1 more source

Aldosterone in Diabetic Kidney Disease: From Mineralocorticoid Receptor Antagonism to Aldosterone Synthase Inhibition. [PDF]

Int J Mol Sci
Braga JR, Holthoff JH, Juncos LA, Thotakura R, Ayub F.   +4 more
europepmc   +1 more source

Fermented Noni Juice Supplementation Attenuates Heart Failure Development in Mice: Involvement of the Pentose Phosphate Pathway

Food Frontiers, Volume 7, Issue 6, November 2026.
ABSTRACT Morinda citrifolia L., commonly known as Noni, is a traditional medicinal plant that has long been utilized in various cultures for its anti‐inflammatory and antioxidant properties. Heart failure (HF) is a significant and growing public health concern worldwide that is characterized by substantial morbidity, mortality, and healthcare costs ...
Min Zhang, Xia Guan, Ruize Lu, Zhangxin Yu, Xuanjia Chen, Jingyao Xu, Guangying Chen, Haiying Zhang, Yan Liu   +8 more
wiley   +1 more source

Steroidal versus Nonsteroidal Mineralocorticoid Receptor Antagonists in CKD. [PDF]

J Am Soc Nephrol
Khan MS, Rashid AM, Flythe JE, Dember LM, Shafi T.   +4 more
europepmc   +1 more source

Resource management and clinical outcomes during a national intravenous fluid shortage

Journal of Hospital Medicine, Volume 21, Issue 11, Page 1244-1251, November 2026.
Abstract Background A natural disaster, Hurricane Helene, damaged a production facility supplying 60% of intravenous (IV) fluids in the United States. A nationwide IV fluid shortage followed. Objectives To evaluate a multifaceted IV fluid conservation intervention's effect on IV fluid utilization and clinical outcomes during the shortage.
Stacy A. Johnson, Erin R. Fox, Smitha Warrier, Russell Vinik   +3 more
wiley   +1 more source

Hypocortisolaemia with gastrointestinal haemorrhage in a young cat

Veterinary Record Case Reports, Volume 14, Issue 4, November 2026.
Abstract An 8‐month‐old, female, spayed domestic shorthair presented with a 1‐week history of lethargy and anorexia. On admission, the cat had severe hypoglycaemia, and hypovolaemic and distributive shock were suspected. Mucosal defects identified by ultrasonography were suggestive of gastrointestinal ulceration.
Victoria J. Skinner, Bronwyn Zimmerman, Ivayla D. Yozova   +2 more
wiley   +1 more source

Discrepancies between forest plots and reported results in mineralocorticoid receptor antagonist meta-analysis of glycaemic outcomes. [PDF]

Br J Clin Pharmacol
Saha L.
europepmc   +1 more source