Results 191 to 200 of about 58,361 (283)

Intercellular communication from myotubes to fibroblasts is differentially impacted by mineralocorticoid receptor signaling and muscular dystrophy. [PDF]

Cell Commun Signal
Krishna S, Gomatam CK, Reddy R, Lowe J, Lepper C, Rafael-Fortney JA.   +5 more
europepmc   +1 more source

A Network Pharmacology and Experimental Validation Strategy for Hypoglycemic Study of Lonicerae Japonicae Flos on Diabetes

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT As diabetes has become an important public health issue, Lonicerae Japonicae Flos (LJF) had gradually attracted increasing attention on diabetes. This study aimed to investigate the hypoglycemic ingredients and underlying mechanisms of LJF in diabetes using an integrated strategy of network pharmacology, molecular docking and experimental ...
Zhang Nan, Liu Xiaolong, Li Chunyan, Ren Lu, Guo Chao, Xue Jintao   +5 more
wiley   +1 more source

Deficiency of mineralocorticoid receptor signalling in myeloid cells protects cardiac and kidney function in hypertensive diabetic mice. [PDF]

Clin Sci (Lond)
Tesch GH, Ozols E, Morgan J, Young MJ, Nikolic-Paterson DJ.   +4 more
europepmc   +1 more source

Clinical significance of renal histological diagnosis in patients with type 2 diabetes and proteinuria atypical for diabetic nephropathy

Journal of Diabetes Investigation, Volume 17, Issue 5, Page 781-790, May 2026.
ABSTRACT Background/Aim Most patients with proteinuria are considered to have typical diabetic nephropathy (DN). However, when proteinuria occurs without diabetic retinopathy, with hematuria, or persists despite strict glycemic and blood pressure control, it is considered atypical for DN and warrants further evaluation for non‐DN via kidney biopsy ...
Shogo Kuwagata, Masami Chin‐Kanasaki, Aki Yamada, Tomonori Sakae, Nahomi Ishimoto, Yoshimi Imamura‐Uehara, Kosuke Yamahara, Mako Yasuda‐Yamahara, Sho Sugahara, Yuki Tanaka‐Sasaki, Natsumi Kuwata, Kimihiro Nishimura, Koichiro Murata, Itsuko Miyazawa, Shogo Ida, Natsuko Ohashi, Shinji Kume   +16 more
wiley   +1 more source

The mineralocorticoid receptor antagonist finerenone enhances cardiovascular recovery upon food intake normalization in obese mice. [PDF]

Cardiovasc Diabetol
Manon MF, Marie PD, Benjamin B, Coralie F, Linghui K, Amhrae ND, Lionel N, Saïda M, Sylvanie R, Anaïs D, Vincent R, Bruno F, Frédéric J, Sheerazed B, Paul M, Antoine OP.   +15 more
europepmc   +1 more source

Impact of renal function on antidiabetic drug selection in Japan: A real‐world analysis using the J‐DREAMS database

Journal of Diabetes Investigation, Volume 17, Issue 5, Page 801-809, May 2026.
Using a large Japanese real‐world database, we examined antidiabetic drug selection in first and second therapy stratified by renal function and study period. The earlier initiation of SGLT2 inhibitors and GLP‐1 receptor agonists increased over time, particularly in second therapy, with prescribing patterns increasingly aligned across renal function ...
Masashi Kubota, Mitsuru Ohsugi, Kohjiro Ueki   +2 more
wiley   +1 more source

Nonsteroidal Versus Steroidal Mineralocorticoid Receptor Antagonists in Heart Failure: Real-World Evidence From a Multicenter Cohort Study. [PDF]

J Am Heart Assoc
Wu JY, Tseng KJ, Lin YM.
europepmc   +1 more source

Brain Proteomic Responses to Glucocorticoids and Their Relationship With Transcriptome: A Systematic Meta‐Analysis

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
An overlap between proteomic and transcriptomic findings in experiments testing brain responses to glucocorticoids. A shows that 455 proteins responsive to glucocorticoids were not confirmed at the transcriptomic level while 4 proteins were matched with significant differences in mRNA in all 8 datasets derived from transcriptomic experiments.
Grzegorz R. Juszczak
wiley   +1 more source

Efficacy and safety of mineralocorticoid receptor antagonists in heart failure: a meta-analysis of randomized controlled trials. [PDF]

BMC Cardiovasc Disord
Wu J, Pei Y, Wu J, Huang Y.
europepmc   +1 more source

Distinct Effects of Maternal Stress and Exercise on Offspring Metabolic Health

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
Maternal exercise improves glucose tolerance in adult male offspring, but this benefit is blunted by maternal stress. Exercise increases offspring corticosterone levels independent of stress, whereas maternal stress upregulates glucocorticoid and mineralocorticoid receptor expression in brown adipose tissue, which is prevented by maternal exercise ...
Felix T. Yang, Joao V. Esteves, Lisa A. Baer, Kelsey M. Pinckard, Branden G. Verosky, Olivia A. Togliatti, Caden Burkhart, Sara A. Alzuhaili, Nickolai P. Seculov, Tamar L. Gur, Kristin I. Stanford   +10 more
wiley   +1 more source