Results 181 to 190 of about 1,369,571 (283)

30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Short reflections on the discovery of the mineralocorticoid receptor [PDF]

Journal of Endocrinology, 2017
openaire   +2 more sources

Advanced Conduction Disease After Incident Heart Failure in Myotonic Dystrophy Type 1

Pacing and Clinical Electrophysiology, EarlyView.
Central Figure. Advanced Conduction Disease After Incident HF in Myotonic Dystrophy Type 1. ABSTRACT Background Myotonic dystrophy type 1 (DM1) is associated with progressive cardiac conduction disease, heart failure (HF) and increased mortality. However, the association of incident HF with conduction disease and survival in DM1 is not well defined ...
Isadora Guarino, Lauren Elman, Gregory Supple, Saman Nazarian   +3 more
wiley   +1 more source

Emerging roles for endothelial mineralocorticoid receptor in disease pathogenesis: potential new indications for mineralocorticoid receptor antagonism. [PDF]

Curr Opin Physiol
An W, Jaffe IZ.
europepmc   +1 more source

Leptin–cholesterol crosstalk in pregnancy: Mechanistic implications for placental function and cardiometabolic programming

Experimental Physiology, EarlyView.
Abstract Pregnancy requires the coordinated maternal reorganization of lipid and endocrine pathways to sustain fetal growth and anticipate neonatal nutrition. Leptin, produced by adipose tissue and the placenta, acts as an integrative signal linking maternal energy status with trophoblast function and vascular adaptation, while cholesterol provides ...
Julio Flores, Diego Gumera, Andreina Arias, Cristián A. Amador, María José Yañez   +4 more
wiley   +1 more source

Early mineralocorticoid receptor antagonism for end-organ protection in hypertension: Implications for disparities and rethinking the timing paradigm. [PDF]

Dialogues Health
Ezeugwu CO.
europepmc   +1 more source

Glucocorticoids modulate drug transporter function in human fetal brain endothelial cells

The Journal of Physiology, EarlyView.
Abstract figure legend P‐glycoprotein and breast cancer resistance protein are the most prominent drug transporters at the fetal blood–brain barrier. We isolated primary human fetal brain endothelial cells from early and mid‐gestation cerebral microvessels and exposed them to glucocorticoids cortisol and dexamethasone in vitro.
Nikola Ivanovski, Phetcharawan Lye, Enrrico Bloise, Stephen G. Matthews   +3 more
wiley   +1 more source

A Novel NR3C1 Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural Modeling

American Journal of Medical Genetics Part A, Volume 200, Issue 12, Page 2719-2737, December 2026.
ABSTRACT Glucocorticoid resistance syndrome (GRS) is a rare hereditary disorder caused by pathogenic variants in NR3C1, characterized by marked phenotypic heterogeneity and frequent misdiagnosis as primary aldosteronism or subclinical Cushing's syndrome.
Sufang Yun, Zhifeng Zhu, Fengye Zhou, Ying Liu, Chunfang Liang, Haitao Ju, Lin Lu, Zhaoli Yan   +7 more
wiley   +1 more source

Mineralocorticoid Receptor Antagonists in Dialysis.

Am J Nephrol
Elenjickal EJ, Mavrakanas TA.
europepmc   +1 more source

Pharmacovigilance profiles of three generations of mineralocorticoid receptor antagonists and network toxicology analysis. [PDF]

Front Med (Lausanne)
Lin HH, Cui WH, Xu F, He JY, Li LC, Xu JJ, Jiang X, Mao KL.   +7 more
europepmc   +1 more source

Subcutaneous Furosemide for Ambulatory Decongestion in Heart Failure: Outcomes From a High‐Risk Real‐World Cohort

Clinical Cardiology, Volume 49, Issue 11, November 2026.
In 49 high‐risk ambulatory heart failure patients with persistent congestion despite oral diuretics, subcutaneous furosemide was well tolerated, with a 20.4% 30‐day HF hospitalization rate. Among non‐hospitalized patients, the median NYHA class improved from III to II, and the weight decreased by 2.6 kg.
Omar Jafar, Ann Harper, Angela Toepp, Amin Yehya   +3 more
wiley   +1 more source