Results 31 to 40 of about 1,320,527 (284)
PLoS ONE, 2014 Aldosterone administration in rats results in several cardiac alterations. Previous studies have demonstrated that proanthocyanidins, phenolic bioactive compounds, have cardioprotective effects.
Beatriz Martín-Fernández +7 more
doaj +1 more source
Hypertension in mice lacking 11beta-hydroxysteroid dehydrogenase type 2 [PDF]
, 1999 Deficiency of 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) in humans leads to the syndrome of apparent mineralocorticoid excess (SAME), in which cortisol illicitly occupies mineralocorticoid receptors, causing sodium retention, hypokalemia ...
Mullins, A J +18 more
core +1 more source
Mineralocorticoid Receptor Antagonists and the Metabolic Syndrome [PDF]
Current Hypertension Reports, 2010 Key components of the metabolic syndrome (MetS), ie, obesity and insulin resistance, are associated with increased aldosterone production and mineralocorticoid receptor (MR) activation. Both MetS and hyperaldosteronism are proinflammatory and pro-oxidative states associated with cardiovascular disease.
Amir, Tirosh +2 more
openaire +2 more sources
Characterization of the 5-HT(7) receptor as a new therapeutic target for the treatment of pain [PDF]
, 2012 [eng] The work showed in this Thesis has been part of the “5-HT7 and neuropathic pain” project in the pharmaceutical company Esteve. Thus, the aim of this Thesis was in line with the goal of the 5-HT7 project at Esteve, focused on drug discovery of 5-HT7
Brenchat Barberà, Àlex
core +6 more sources
Lack of Association Between Neurohormonal Blockade and Survival in Transthyretin Cardiac Amyloidosis
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021 Background Despite the belief that heart failure therapies are not effective in transthyretin cardiac amyloidosis, data are limited. We tested the association of neurohormonal blockade use with survival.
Richard K. Cheng +6 more
doaj +1 more source
Journal of Pharmacological Sciences, 2010 We examined the role of aldosterone-sensitive neurons in the nucleus tractus solitarius (NTS) in the arterial baroreceptor reflex (baroreflex) function. Baroreflex sensitivity was induced by phenylephrine in high sodium–loaded rats and was significantly ...
Tomoharu Masuda +10 more
doaj +1 more source
Mineralocorticoid receptor blockade during a rat's first violent encounter inhibits its subsequent propensity for violence. [PDF]
, 2013 In individuals naive to serious conflict in an unfamiliar environment, violence has long-lasting effects on subsequent aggressive behavior. This effect of the stressful experience of a first violent conflict occurs in victims as well as offenders.
Meelis, W. +6 more
core +1 more source
Mineralocorticoid receptor antagonists for heart failure [PDF]
Expert Opinion on Pharmacotherapy, 2011 Although mineralocorticoid receptor (MR) antagonists are indicated in systolic heart failure, they are underprescribed in patients with appropriate indications for their prescription and often used in those in whom the evidence for probable benefit is scant.
openaire +4 more sources
Palosuran: clinical pharmacology of a urotensin-II receptor antagonist in type 2 diabetes mellitus [PDF]
, 2015 Type 2 Diabetes Mellitus (Type 2 DM) is a growing global public health threat, leading to a significant cost burden to society. Type 2 DM increases the risk of hypertension and associated macro- and microcardiovascular diseases, affecting the eyes ...
Sidharta, Patricia N.
core +1 more source
The Ascent of Mineralocorticoid Receptor Antagonists in Diabetic Nephropathy [PDF]
Current Clinical Pharmacology, 2019 Diabetic nephropathy is defined as a decline in the renal function and an increase in the amount of albuminuria (>300 mg/day). The interruption of the renin-angiotensin-aldosterone system (RAAS) by well-established therapies such as angiotensin-converting enzyme inhibitor, angiotensin receptor blockers, calcium channel blockers or diuretics has been
Goenka, Luxitaa +2 more
openaire +2 more sources