Results 21 to 30 of about 1,320,527 (284)

The effect of eplerenone on adenosine formation in humans in vivo: a double-blinded randomised controlled study. [PDF]

PLoS ONE, 2014
It has been suggested that mineralocorticoid receptor antagonists have direct cardioprotective properties, because these drugs reduce mortality in patients with heart failure.
T N A van den Berg, Jaap Deinum, Albert Bilos, A Rogier T Donders, Gerard A Rongen, Niels P Riksen   +5 more
doaj   +1 more source

Mineralocorticoid Receptor Antagonism Prevents the Synergistic Effect of Metabolic Challenge and Chronic Kidney Disease on Renal Fibrosis and Inflammation in Mice

Frontiers in Physiology, 2022
Obesity and/or metabolic diseases are frequently associated with chronic kidney disease and several factors associated with obesity may contribute to proteinuria and extracellular matrix production.
Roberto Palacios-Ramirez, Ixchel Lima-Posada, Benjamin Bonnard, Marie Genty, Amaya Fernandez-Celis, Judith Hartleib-Geschwindner, Fabienne Foufelle, Natalia Lopez-Andres, Krister Bamberg, Frederic Jaisser, Frederic Jaisser   +10 more
doaj   +1 more source

Eplerenone–A novel Mineralocorticoid receptor antagonist for the clinical application

Environmental Disease, 2022
Aldosterone is produced from the zona glomerulosa of the adrenal cortex in the adrenal gland, which is main mineralocorticoid hormone. Upon binding the mineralocorticoid receptor, it regulates sodium and potassium absorption, secretion, and retention ...
Nan-Nan Wu, Yuan-Yuan Zhang, Dong Zhao
doaj   +1 more source

Exclusion of the Locus for Autosomal Recessive Pseudohypoaldosteronism Type 1 from the Mineralocorticoid Receptor Gene Region on Human Chromosome 4q by Linkage Analysis. [PDF]

, 1995
Pseudohypoaldosteronism type 1 (PHA1) is an uncommon inherited disorder characterized by salt-wasting in infancy arising from target organ unresponsiveness to mineralocorticoids.
Hanukoglu, A., Gardiner, R.M., Bistritzer, T., Seckl, J., Chung, E., Kuhnle, U., Dillon, M., Gardiner, R. M., Hanukoglu, I., Rees, M., Thompson, R.   +10 more
core   +1 more source

Mineralocorticoid receptor overactivation-induced remodeling of obese adipose tissue [PDF]

Xin yixue
Obesity is a chronic disease caused by the long-term interaction of multiple environmental factors on a specific genetic background. Among these factors， the overactivation of mineralocorticoid receptors （MR） plays a significant role in adipose tissue ...
WEN Runzhi, WANG Li, ZHAO Naiqian
doaj   +1 more source

Conformation of the Mineralocorticoid Receptor N-terminal Domain: Evidence for Induced and Stable Structure [PDF]

, 2010
The mineralocorticoid receptor (MR) binds the steroid hormones aldosterone and cortisol and has an important physiological role in the control of salt homeostasis.
Fischer, Katharina, Watt, Carolyn, McEwan, Iain Joseph, Nicholas C. Price, Kelly, S.M., Katharina Fischer, Price, N.C., McEwan, I. J., Watt, K., Fischer, K., Price, Nicholas C., Sharon M. Kelly, Kate Watt, Iain J. McEwan, Kelly, Sharon M.   +14 more
core   +1 more source

Mineralocorticoid receptor antagonist use following heart failure hospitalization

ESC Heart Failure, 2020
Aims Patients hospitalized for heart failure (HF) are at increased risk for events post‐discharge. Mineralocorticoid receptor antagonists (MRAs) improve the clinical course of patients with HF with reduced ejection fraction.
Jason M. Duran, Shady Gad, Alison Brann, Barry Greenberg   +3 more
doaj   +1 more source

Major Adverse Cardiovascular Events in Primary Aldosteronism After Adrenalectomy or Mineralocorticoid Receptor Antagonist Treatment: A Systematic Review and Meta‐Analysis [PDF]

Journal of the American Heart Association
Chien-Wei Huang, Vin-Cent Wu, Yu-Kang Tu   +2 more
exaly   +2 more sources

3D models of lamprey corticoid receptor complexed with 11-deoxycortisol and deoxycorticosterone [PDF]

, 2011
The serum of Atlantic sea lamprey, a basal vertebrate, contains two corticosteroids, 11-deoxycortisol and deoxycorticosterone. Only 11-deoxycortisol has high affinity [Kd~3 nM] for the corticoid receptor [CR] in lamprey gill cytosol. To investigate the
Paiyuam Asnaashari, Michael E. Baker, Kayla Y. Uh   +2 more
core   +1 more source

Temporal and spatial dynamics of corticosteroid receptor down-regulation in rat brain following social defeat [PDF]

, 2001
The experiments explored the nature and time course of changes in glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) binding in homogenates of various brain regions and pituitary of male Wistar rats following social defeat stress.
Horváth, K.M., Bohus, B., Bohus, B, Bauke Buwalda, Nyakas, C, Felszeghy, K., Felszeghy, K, Béla Bohus, Klára Felszeghy, Horváth, Katalin M.,, Koolhaas, J M, Buwalda, B, Boer, Sietse F. de,, Nyakas, Csaba,, Csaba Nyakas, Katalin M Horváth, de Boer, S.F., Felszeghy, Klára,, Koolhaas, J.M., Sietse F de Boer, Koolhaas, Jaap M.,, Nyakas, C., Buwalda, Bauke,, Horváth, K M, Buwalda, B., Bohus, Béla,, Jaap M Koolhaas   +26 more
core   +1 more source