Results 41 to 50 of about 1,320,527 (284)
Kinin-B1 receptors in ischaemia-induced pancreatitis: Functional importance and cellular localisation [PDF]
, 2003 In this study we compare the role of kininB1 and B2 receptors during ischaemia/reperfusion of rat pancreas. Our investigations were prompted by the observation that infusion of a kininB2 receptor antagonist produced significant improvement in acute ...
A. A. Roscher +11 more
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Human mineralocorticoid receptor interacts with actin under mineralocorticoid ligand modulation [PDF]
, 1996 The human mineralocorticoid receptor of the steroid receptor family contains a modular structure with domain E which is considered to be a hormone binding domain.
Stéphan Jalaguier +9 more
core +1 more source
, 2021 Hyperkalemia is a challenging comorbidity to manage in patients with heart failure and chronic kidney disease, particularly when administering renin-angiotensin-aldosterone system inhibitors.
Imamura, Teruhiko +6 more
core +1 more source
Терапевтический архив, 2023 Chronic kidney disease (CKD) is one of the most common complications of diabetes mellitus and an independent risk factor for cardiovascular disease. Despite guideline-directed therapy of CKD in patients with type 2 diabetes, the risk of renal failure and
Vladimir V. Salukhov +2 more
doaj +1 more source
Mineralocorticoid receptor antagonists in cardiovascular translational biology
Cardiovascular Endocrinology & Metabolism, 2023 This review examines the role of mineralocorticoid receptor antagonists (MRAs) in cardiovascular biology and the molecular mechanisms involved in mineralocorticoid receptor antagonism. The data discussed suggest that MRAs can play an important role in decreasing the impact of inflammation and fibrosis on cardiorenal outcomes.
Chilton, Robert J., Silva-Cardoso, José
openaire +2 more sources
Mineralocorticoid receptor antagonists: The evolution of utility and pharmacology [PDF]
, 2000 Mineralocorticoid receptor antagonists: The evolution of utility and pharmacology. For more than 30 years after the discovery of aldosterone, scientists believed that its sole site of action was at epithelial tissues, most notably the kidney, where it ...
Delyani, John A.
core +1 more source
The aldosterone-mineralocorticoid receptor pathway exerts anti-inflammatory effects in endotoxin-induced uveitis. [PDF]
PLoS ONE, 2012 We have previously shown that the eye is a mineralocorticoid-sensitive organ and we now question the role of mineralocorticoid receptor (MR) in ocular inflammation.
Elodie Bousquet +11 more
doaj +1 more source
Mineralocorticoid Receptor Activation and Mineralocorticoid Receptor Antagonist Treatment in Cardiac and Renal Diseases [PDF]
Hypertension, 2015 Cardiac and renal diseases remain major challenges for healthcare systems in developed countries and commonly coexist, with a disorder in the heart or kidney often leading to secondary dysfunction or injury in the other organ. Indeed, the term cardiorenal syndrome has been introduced to describe the broad spectrum of disease involving both the heart ...
Johann, Bauersachs +2 more
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Journal of Chemical ResearchInappropriate overactivation of the mineralocorticoid receptor by the steroid hormones aldosterone or cortisol contributes to the development of cardiovascular diseases.
Mingguang Zhang +4 more
doaj +1 more source
Journal of Cardiovascular Development and Disease, 2023 Patients with cardiovascular disease (CVD) and chronic kidney disease (CKD) show high rates of cardiorenal outcomes. In addition, the progression towards renal failure and cardiovascular events rises as CKD worsens.
Francesco Piccirillo +8 more
doaj +1 more source