Results 121 to 130 of about 1,419,720 (263)

Systematic Review: Mineralocorticoid Receptor Antagonists in Heart Failure with Preserved and Mildly Reduced Ejection Fraction

Heart failure with preserved ejection fraction (HFpEF) or mildly reduced ejection fraction (HFmrEF) is a prevalent condition associated with significant morbidity and mortality, and the benefits of mineralocorticoid receptor antagonists (MRAs) remain ...
Fabiana G. Marcondes-Braga, Lidia Ana Zytynski Moura, Luiz Claudio Danzmann, Marcus Vinicius Simões, José Albuquerque de Figueiredo Neto, Ricardo Mourilhe-Rocha, Denilson Campos de Albuquerque, Sílvia Marinho Martins, Mucio Tavares de Oliveira Jr   +8 more
core   +1 more source

Pharmacokinetic and Pharmacodynamic Interactions Between Anti‐Asthma Drugs and Medicinal Plants: A Comprehensive Review

Phytotherapy Research, EarlyView.
ABSTRACT Asthma affects 260–300 million people worldwide. About 20%–35% of patients use medicinal plants with their asthma medication, often without telling their clinicians. Disclosure rates are low; up to 42% of asthma outpatients use herbal products, with no records in their charts.
Emine Kocyigit, Aylin Bülbül, Betul Kocaadam‐Bozkurt, Osman Bozkurt, Duygu Ağagündüz, Raffaele Capasso   +5 more
wiley   +1 more source

Astragaloside IV Restores Autophagy and Inhibits Apoptosis for Podocyte Protection in Diabetic Nephropathy by Inhibiting Notch1 Signaling via SIRT6‐Mediated Deacetylation

Phytotherapy Research, EarlyView.
AS‐IV binds to SIRT6 and promotes H3K9 deacetylation at the Notch1 promoter, inhibiting gene transcription (Created with BioGDP.com). ABSTRACT Astragaloside IV (AS‐IV) has demonstrated efficacy in ameliorating proteinuria and attenuating renal tubular damage in preclinical diabetic nephropathy (DN) models.
Qiyu Yue, Chen Yong, Xinran Wang, Yang Shu, Min Yao, Yongfei Yu, Yubai Xue, Rong Deng, Tianlu Chu, Weiwei Tao, Min Zhao, Enchao Zhou   +11 more
wiley   +1 more source

Mineralocorticoid receptor antagonists for treatment of chronic heart failure (review of literature)

, 2017
В огляді літератури наводяться результати досліджень щодо застосування антагоністів мінералокортикоїдних рецепторів альдостерону спіронолактону і еплеренону в осіб із хронічною серцевою недостатністю.В литературном обзоре приводятся результаты ...
Петринич, О.А., Казанцева, Тетяна Василівна, Petrynych, O.A., Білецький, Семен Віссаріонович, Бойко, Василь Васильович, Kazantseva, T.V., Билецкий, С.В., Бойко, В.В., Biletskyi, S.V., Казанцева, Т.В., Петринич, Оксана Анатоліївна, Boyko, V.V.   +11 more
core   +1 more source

Care and Outcomes of New‐Onset Heart Failure Across Vulnerable Populations: Temporal Trends in Mortality and Treatment in a Danish Nationwide Cohort From 2003 to 2022

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Heart failure (HF) prevalence is increasing. In a nationwide cohort study, we investigated temporal trends in care and outcomes of patients with new‐onset HF within vulnerable populations.
Sofie‐Louise Feentved Ødum, Clara Friis, Caroline Hartwell Garred, Nina Nouhravesh, Deewa Zahir Anjum, Camilla Fuchs Andersen, Jesper Jensen, Emil Fosbøl, Lars Køber, Daniel Mølager Christensen, Marte Austreim, Morten Malmborg, Morten Schou, Mariam Elmegaard   +13 more
doaj   +1 more source

Incidence of Childhood Dilated Cardiomyopathy in Sweden From 1991 to 2019: A National Population‐Based Study

Acta Paediatrica, EarlyView.
ABSTRACT Aim To study the incidence, survival, and mortality of dilated cardiomyopathy (DCM) in children in Sweden, 1991–2019. Methods Hospital records of 0–18‐year‐olds diagnosed with DCM over a 29‐year period were reviewed. The annual sex‐specific incidence rates of DCM were calculated as new disease cases, divided by the average Swedish same‐sex ...
Shalan Fadl, Stefan Särnblad, Tahir Taj, Håkan Wåhlander, Eva Fernlund, Jan Sunnegårdh   +5 more
wiley   +1 more source

A comprehensive review of cancer‐induced cardiac wasting

British Journal of Pharmacology, EarlyView.
Cancer is frequently accompanied by cachexia, a systemic syndrome characterized by progressive loss of skeletal muscle mass, with or without loss of fat mass. Increasing evidence indicates that cancer can also induce cardiac muscle wasting, which is associated with structural cardiac remodelling, impaired contractile function and the development of ...
Alessia Lena, Muhammad Shahzeb Khan, Ulrich Keller, Lars Bullinger, Dominik P. Modest, Markus S. Anker   +5 more
wiley   +1 more source

Discovery of Benzimidazole Oxazolidinediones as Novel and Selective Nonsteroidal Mineralocorticoid Receptor Antagonists

, 2015
Elaboration of the oxazolidinedione series led to replacement of the exocyclic amides with substituted benzimidazoles. The structure–activity relationship (SAR) exploration resulted in the discovery of potent and selective nonsteroidal mineralocorticoid ...
Ling Xu (117663), Beata Zamlynny (1417051), Peter Sinclair (1622335), Martin Crook (1622359), Sheng Gao (44512), Jaume Balsells (1458115), Judyann Wiltsie (1622350), Christine Yang (149071), JeanMarie Lisnock (1622344), Margarita Garcia-Calvo (1463782), Xiuying Ma (1601794), Gaochao Zhou (1601800), Jason M. Cox (1622332), Joseph Clemas (1622341), Lisa Contino (1622353), Hong D. Chu (1622347), Alejandro Crespo (1445995), Patricia Brown (1622338), Jack Gibson (1601797), Vincent Tong (1570804), Hong C. Shen (1622356), Thomas J. Bateman (1622362)   +21 more
core   +1 more source

Nephrological perspectives on the underutilization of SGLT2is in heart failure and chronic kidney disease

ESC Heart Failure, Volume 12, Issue 2, Page 1490-1491, April 2025.
Özant Helvacı, Ömer Faruk Akçay, Emre Yaşar, Ülver Derici, Galip Güz   +4 more
wiley   +1 more source

Heart failure medication to prevent cancer therapy–related cardiac dysfunction: A narrative review

British Journal of Pharmacology, EarlyView.
Advances in oncological therapies have improved cancer survival but also have increased the clinical incidence of cancer therapy–related cardiac dysfunction (CTRCD), a spectrum of conditions ranging from subclinical biomarker or strain abnormalities to progressive heart failure and cardiogenic shock.
Fabian Voß, Paul Goerke, Malte Kelm, Amin Polzin   +3 more
wiley   +1 more source