Results 221 to 230 of about 31,334 (301)

Protective Effects of Agrimonia pilosa Ledeb. In Myocardial Fibrosis: Inhibition of Mitophagy Mediated by the FOXO Signaling Pathway

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Agrimonia pilosa Ledeb. has the effect of repairing myocardial injury, reducing myocardial hypertrophy, and improving MF. Mechanistically, it acts by inhibiting mitophagy mediated by the FOXO signaling pathway, as validated via network pharmacology, in vitro, and in vivo experiments. ABSTRACT Agrimonia pilosa Ledeb.
Jian Chen, Zhixiang Wei, Jiaqi An, Dantong Li, Ying Gu, Yixin Zhang, Muqing Zhang   +6 more
wiley   +1 more source

No Significant Role for Smooth Muscle Cell Mineralocorticoid Receptors in Atherosclerosis in the Apolipoprotein-E Knockout Mouse Model. [PDF]

Front Cardiovasc Med, 2018
Moss ME, DuPont JJ, Iyer SL, McGraw AP, Jaffe IZ.   +4 more
europepmc   +1 more source

Female Sex as a Major Risk Factor for Dabigatran‐Induced Esophagitis in Atrial Fibrillation Ablation

Journal of Arrhythmia, Volume 42, Issue 2, April 2026.
Dabigatran‐induced esophagitis occurred in 18.7% of patients undergoing atrial fibrillation ablation. Female sex was identified as an independent predictor of this complication, highlighting the need for careful periprocedural management and preventive strategies in women.
Daiki Saito, Hidehira Fukaya, Takuya Wada, Jun Oikawa, Sho Ogiso, Yusuke Murayama, Tetsuro Sato, Gen Matsuura, Yuki Arakawa, Shuhei Kobayashi, Hironori Nakamura, Naruya Ishizue, Jun Kishihara, Shinichi Niwano, Satoshi Tanabe, Chika Kusano, Junya Ako   +16 more
wiley   +1 more source

Glucocorticoid Receptor-Tethered Mineralocorticoid Receptors Increase Glucocorticoid-Induced Transcriptional Responses.

Endocrinology, 2019
Rivers CA, Rogers MF, Stubbs FE, Conway-Campbell BL, Lightman SL, Pooley JR.   +5 more
europepmc   +1 more source

Predictors and Outcomes of Pharmacological and Electrical Cardioversion for Atrial Fibrillation and Flutter in an Indian Emergency Department: A Retrospective Study

Journal of Arrhythmia, Volume 42, Issue 2, April 2026.
In a real‐world emergency department study of atrial fibrillation and flutter, cardioversion restored sinus rhythm in 68% of patients. Electrical cardioversion achieved the highest success, while pharmacological and mixed strategies predicted failure. Complications were infrequent but clinically significant.
Abid M. Sadiq, Bhavana Keerthiparti, Kapil Kumawat, Deepak Padmanabhan   +3 more
wiley   +1 more source

Sex‐Specific Gene Expression Ontogeny During Gonadal Development in Post‐Metamorphic Xenopus tropicalis

Molecular Reproduction and Development, Volume 93, Issue 4, April 2026.
Post‐metamorphic gonadal development in Xenopus tropicalis was analyzed through integrated morphometric, histological, and transcriptional approaches. Males showed upregulation of cyp17, amh, and amhr2, whereas females exhibited an increased aldh1a2 and ddx4.
Daniele Marini, Mauricio Roza, Cecilia Berg, Vanessa Brouard   +3 more
wiley   +1 more source

Mineralocorticoid receptors: an appealing target to treat coronary microvascular dysfunction in diabetes. [PDF]

Diabetes, 2015
Bender SB, Jia G, Sowers JR.
europepmc   +1 more source

11 β-hydroxysteroid dehydrogenase—why is it important for the nephrologist? [PDF]

, 2017
Escher, G., Frey, B. M., Frey, F. J.
core  

A Circadian Trough in Glucocorticoid Signaling Is Essential for Bone Health in Mice

Aging Cell, Volume 25, Issue 4, April 2026.
Flattening the circadian rhythm of endogenous glucocorticoids induces osteoporosis in mice. We demonstrate that reinstating a trough in glucocorticoid receptor signaling stimulates bone formation and suffices to prevent osteoporosis. Reinstating the trough at its natural time of day is needed for full protection.
Annelies E. Smit, Kaiming Yue, Sander Kooijman, Salwa Afkir, Maaike Schilperoort, Marijke Koedam, Bram C. J. van der Eerden, Jan Kroon, Onno C. Meijer, Elizabeth M. Winter   +9 more
wiley   +1 more source

The anti‐fibrotic effects of novel heart failure pharmacotherapies in advanced heart failure patients

British Journal of Pharmacology, Volume 183, Issue 7, Page 1502-1516, April 2026.
Background and Purpose Novel heart failure (HF) pharmacotherapies, including angiotensin receptor‐neprilysin inhibitor (ARNI) and sodium‐glucose cotransporter 2 inhibitors (SGLT2is), may confer cardiovascular benefits by attenuating myocardial fibrosis. However, direct evidence from human failing myocardial samples is limited.
Dávid Nagy, Tamás Radovits, Tímea Bálint, Zoltán Horváth, Petra Kocsis‐Balogh, Ákos Gergely Tóth, Attila Oláh, Alex Ali Sayour, Bálint András Barta, Béla Merkely, Mihály Ruppert   +10 more
wiley   +1 more source