Results 81 to 90 of about 1,341,600 (296)

Sleep dysfunction and EEG alterations in mice overexpressing alpha-synuclein. [PDF]

, 2014
BackgroundSleep disruptions occur early and frequently in Parkinson's disease (PD). PD patients also show a slowing of resting state activity. Alpha-synuclein is causally linked to PD and accumulates in sleep-related brain regions.
Chesselet, Marie-Françoise, McDowell, Kimberly A, Roos, Kenneth P, Shin, David   +3 more
core  

Minimally invasive biomarker confirms glial activation present in Alzheimer's disease: a preliminary study

Neuropsychiatric Disease and Treatment, 2011
We applied (13)C magnetic resonance spectroscopy (MRS), a nonradioactive, noninvasive brain imaging technique, to quantify the oxidation of [1-(13)C] acetate in a conventional clinical magnetic resonance imaging (MRI) scanner in five consecutive elderly subjects at various clinical stages of Alzheimer's disease (AD) progression.
Sailasuta, Napapon, Harris, Kent, Tran, Thao, Ross, Brian   +3 more
openaire   +3 more sources

Exercise Interventions in Children, Adolescents and Young Adults With Paediatric Bone Tumours—A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Bone tumours present significant challenges for affected patients, as multimodal therapy often leads to prolonged physical limitations. This is particularly critical during childhood and adolescence, as it can negatively impact physiological development and psychosocial resilience.
Jennifer Queisser, Claire Laurie, Teresa Schmidt, Irene von Luettichau, Peter Bekkering, Sabine Kesting   +5 more
wiley   +1 more source

Treatment recommendations for psoriatic arthritis [PDF]

, 2008
Objective: To develop comprehensive recommendations for the treatment of the various clinical manifestations of psoriatic arthritis (PsA) based on evidence obtained from a systematic review of the literature and from consensus opinion.
Boehncke, Wolf-Henning, Fiorentino, David, FitzGerald, Oliver, Gladman, Dafna D., Gottlieb, Alice B., Helliwell, Philip, Kavanaugh, Arthur, McHugh, Neil J., Mease, Philip J., Nash, Peter, Qureshi, Abrar A., Ritchlin, Christopher T., Soriano, Enrique R., Taylor, William J., Vlam, Kurt de   +14 more
core   +3 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Quantification of pre-existing radiographic damage and its relationship with joint activity and long-term clinical outcomes with secukinumab therapy in patients with psoriatic arthritis

Arthritis Research & Therapy, 2022
Background Psoriatic arthritis (PsA) patient data from two phase 3 secukinumab trials (FUTURE 1, 5) were analysed to quantify the prevalence and extent of pre-existing radiographic damage (RD) at baseline; investigate the association of RD with swollen ...
Philip Mease, Désirée van der Heijde, Bruce Kirkham, Georg Schett, Ana-Maria Orbai, Christopher Ritchlin, Joseph F. Merola, Luminita Pricop, David A. James, Xuan Zhu, Gregory Ligozio   +10 more
doaj   +1 more source

Waiting Room Health Promotion for Older Adults in Rural Primary Care [PDF]

, 2016
Background: Advances in health care technology have lead to adults living longer than in previous decades. Longer life expectancy in combination with the aging of the Baby Boomer generation is predicted to result in rapid and exponential growth among the
Kopecky, Emma G
core   +1 more source

TGF-b2 induction regulates invasiveness of theileria-transformed leukocytes and disease susceptibility [PDF]

, 2010
Theileria parasites invade and transform bovine leukocytes causing either East Coast fever (T. parva), or tropical theileriosis (T. annulata). Susceptible animals usually die within weeks of infection, but indigenous infected cattle show markedly reduced
A Moustakas, A Tsapara, Brian R. Shiels, D Haller, DA Dobbelaere, Dirk Werling, DJ Brown, DK Singh, E Schreiber, EJ Glass, EJ Glass, Elizabeth J. Glass, F Biname, F Plattner, G Steger, Gordon Langsley, GT Charras, J Guergnon, J Ham, J Massague, J Massague, Jonathan B. Weitzman, JS Kim, K Jensen, K McGuire, Kirsty Jensen, M Baumgartner, M Cordenonsi, Marie Chaussepied, Martin Baumgartner, MF Moreau, MW Pfaffl, Natacha Janski, PJ Hanley, R Adamson, R Breitling, R Lizundia, R Lizundia, RA Irizarry, Regina Lizundia, RP Somerville, S Itoh, S Narumiya, SS Huang, TL Criswell, TV Do, V Sanz-Moreno, V Sanz-Moreno, Volker Theo Heussler, William Weir, YE Zhang, YM Fleming   +51 more
core   +8 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Set targets, assess response, intervene early to achieve minimal disease activity in atopic dermatitis (STRIVE AD): A modified Delphi consensus project to optimize management of atopic dermatitis in the United KingdomCapsule Summary

JAAD International
Background: Guidelines for the management and treatment of atopic dermatitis have been extensively published in Europe and globally, however these are not always relevant to the United Kingdom (UK) clinical setting.
Maria Angeliki Gkini, MD, MSc, PhD, Helen Alexander, MD, Maria Barfoot, MSc, Alberto Barea, RN, BSc, MSc, Paula E. Beattie, MBBCh, BaO, BSc, MRCP, MD, Firas C. Kreeshan, MBBS, MSc, MRCP, Deborah Moffitt, BSc, MBBS, MRCP, Padma Mohandas, MRCP, MRCGP, MSc, Andrew E. Pink, BMed Sci (Hons), BMBS, PhD, MRCP, Andrew Proctor, BSc (Hons), Ann Sergeant, MBChB, Laura J. Savage, PhD   +11 more
doaj   +1 more source