Results 41 to 50 of about 87,090 (215)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Quantifying the environmental and food biodiversity impacts of ultra-processed foods: evidence from the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Public Health Nutrition
Objective: While associations of ultra-processed food (UPF) consumption with adverse health outcomes are accruing, its environmental and food biodiversity impacts remain underexplored.
Jeroen Berden, Giles T. Hanley-Cook, Bernadette Chimera, Dagfinn Aune, Maria Gabriela M. Pinho, Geneviève Nicolas, Bernard Srour, Christopher J. Millett, Emine Koc Cakmak, Emmanuelle Kesse-Guyot, Esther M. González-Gil, Eszter P. Vamos, Jessica Blanco Lopez, Julia Baudry, Justine Berlivet, Kiara Chang, Mathilde Touvier, Charlotte Le Cornet, Chloé Marques, Christina C. Dahm, Daniel B. Ibsen, Franziska Jannasch, Guri Skeie, Maria-José Sanchez, Matthias B. Schulze, Sara Grioni, Yvonne T. van der Schouw, Ana M. Jimenez Zabala, Anna Winkvist, Anne Tjønneland, Carlotta Sacerdote, Cecilie Kyrø, Elisabette Weiderpass, Marcela Guevara, Pauline Frenoy, Rosario Tumino, Salvatore Panico, Verena Katzke, Xuan Ren, Paolo Vineis, Pietro Ferrari, Carl Lachat, Inge Huybrechts   +42 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

The residues of fruit and vegetable processing: from "waste" to "resource" of natural phytochemical compounds

Advances in Horticultural Science, 2020
The project of Sant’Anna School, in line with the Italian legislation on limiting waste and promoting the redistribution of surpluses and unused goods, aimed to study the potential healthy value of residues obtained from the transformation of fruit and ...
Susanna Bartolini, M. Orlando, Alice Trivellini, F. Venturi, C. Sanmartin, I. Taglieri, M. Macaluso, A. Zinnai, Anna Mensuali-Sodi   +8 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Avoid ultra-processed foods, not food processing: Why processed foods matter for nutrition security, economic growth, gender equality, and sustainability agendas in Africa

World Nutrition
With rising levels of obesity and associated non-communicable diseases in Africa, there is an increasing concern with regards to ultra-processed foods.
Hannah Ameye, Katrin Glatzel
doaj   +1 more source

Effects of Household Washing on the Reduction of Microbiological Contamination of Minimally Processed Vegetables

Scientific Journal of Gdynia Maritime University, 2018
Fresh vegetables are highly recommended in any diet, virtually without quantitative restriction. The consumption of minimally processed vegetables has increased in recent years, among others due to their convenience and health benefits.
A. Kukułowicz
doaj   +1 more source