Results 41 to 50 of about 81,081 (261)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Quantifying the environmental and food biodiversity impacts of ultra-processed foods: evidence from the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Public Health Nutrition
Objective: While associations of ultra-processed food (UPF) consumption with adverse health outcomes are accruing, its environmental and food biodiversity impacts remain underexplored.
Jeroen Berden, Giles T. Hanley-Cook, Bernadette Chimera, Dagfinn Aune, Maria Gabriela M. Pinho, Geneviève Nicolas, Bernard Srour, Christopher J. Millett, Emine Koc Cakmak, Emmanuelle Kesse-Guyot, Esther M. González-Gil, Eszter P. Vamos, Jessica Blanco Lopez, Julia Baudry, Justine Berlivet, Kiara Chang, Mathilde Touvier, Charlotte Le Cornet, Chloé Marques, Christina C. Dahm, Daniel B. Ibsen, Franziska Jannasch, Guri Skeie, Maria-José Sanchez, Matthias B. Schulze, Sara Grioni, Yvonne T. van der Schouw, Ana M. Jimenez Zabala, Anna Winkvist, Anne Tjønneland, Carlotta Sacerdote, Cecilie Kyrø, Elisabette Weiderpass, Marcela Guevara, Pauline Frenoy, Rosario Tumino, Salvatore Panico, Verena Katzke, Xuan Ren, Paolo Vineis, Pietro Ferrari, Carl Lachat, Inge Huybrechts   +42 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Preservation of minimally processed 'aurora-1' peaches using additives

Revista Brasileira de Fruticultura, 2011
'Aurora-1' peaches establishes an interesting alternative as a minimally processed product, due to its characteristics like flavor, color, smell, and also because of its handling resistance.
Ramilo Nogueira Martins, Ben-Hur Mattiuz, Leandra Oliveira Santos, Cristiane Maria Ascari Morgado, Claudia Fabrino Machado Mattiuz   +4 more
doaj   +1 more source

Cell motility as an energy minimization process

Physical Review E, 2022
The dynamics of active matter driven by interacting molecular motors has a non-potential structure at the local scale. However, we show that there exists a quasi-potential effectively describing the collective self-organization of the motors propelling a cell at a continuum active gel level.
H. Chelly, P. Recho
openaire   +4 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Effects of Household Washing on the Reduction of Microbiological Contamination of Minimally Processed Vegetables

Scientific Journal of Gdynia Maritime University, 2018
Fresh vegetables are highly recommended in any diet, virtually without quantitative restriction. The consumption of minimally processed vegetables has increased in recent years, among others due to their convenience and health benefits.
A. Kukułowicz
doaj   +1 more source