Results 41 to 50 of about 37,100 (297)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
BMC Geriatrics, 2018 Background Frailty in older adults is a condition characterised by a loss or reduction in physiological reserve resulting in increased clinical vulnerability.
Rosie Burn +6 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Loveless. Minimum Dwelling and Its Discontents [PDF]
, 2018 Minimum dwelling commonly refers to an extremely reduced space for living, and as such it is associated with typologies such as the micro-flat, the micro-house or the studio-apartment.
Tattara, Martino, Aureli, Pier Vittorio
core
Preventive Home Visits for Mortality, Morbidity, and Institutionalization in Older Adults: A Systematic Review and Meta-Analysis [PDF]
, 2014 Background Home visits for older adults aim to prevent cognitive and functional impairment, thus reducing institutionalization and mortality. Visitors may provide information, investigate untreated problems, encourage medication compliance, and ...
Grant, S. +29 more
core +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Sensors, 2021 (1) Background: The purpose of this study was to evaluate the day-to-day variability and year-to-year reproducibility of an accelerometer-based algorithm for sit-to-stand (STS) transitions in a free-living environment among community-dwelling older ...
Antti Löppönen +8 more
doaj +1 more source
Spatial Characteristics and Transition of ‘Minimum Dwelling’ in Japan
KIEAE Journal, 2019 Purpose: Currently, housing problems are very important part of the social task to be solved. And one of the ways to solve these housing problems is that Minimum Dwelling is becoming a trend of residential. Therefore this paper analyzed the space, and examined the characteristics and changes of the space. Method: Since the modern era, the transition of
openaire +1 more source
CoRR, 2014 Discrete-time switched linear systems where switchings are governed by a digraph are considered. The minimum (or average) dwell time that guarantees the asymptotic stability can be computed by calculating the maximum cycle ratio (or maximum cycle mean) of a doubly weighted digraph where weights depend on the eigenvalues and eigenvectors of subsystem ...
Ferruh Ilhan, Özkan Karabacak
openaire +2 more sources
Minimum energy-maximum space:higher-density attached family housing [PDF]
, 2011 In 2016 all new houses in England and Wales must be zero carbon. To date most work in zero carbon housing has been carried out on detached family housing typologies.
Burford, N.K. +2 more
core +2 more sources