Results 51 to 60 of about 37,100 (297)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Barcoding results for Pseudosimochromis, Simochromis and the other “sediment dwelling” tropheine genera. [PDF]

, 2015
Comparison of intra- (left column) and inter-specific (minimum-maximum) gamma-corrected pairwise genetic distances (in %) for COI.Barcoding results for Pseudosimochromis, Simochromis and the other “sediment dwelling” tropheine genera.
Tine Huyse (370703), Jos Snoeks (266525), Maarten P. M. Vanhove (170205), Maarten Van Steenberge (732001), Antoine Pariselle (322456), Filip A. M. Volckaert (218575)   +5 more
core   +1 more source

Ageism and psychosocial variables during the COVID-19 pandemic: a scoping review protocol

Geriatrics, Gerontology and Aging, 2021
OBJECTIVE: To map studies that focused on the effects of the coronavirus disease 2019 (COVID-19) pandemic on the mental health, well-being, self-perception of aging, and intergenerational relationships of older adults, and how ageism affected these ...
Ellen Cristine Rocha Cabral Nunes, Gabriela Cipolli, Deusivania Vieira da Silva Falcão   +2 more
doaj   +1 more source

Stabilization for a class of minimum phase hybrid systems under an average dwell‐time constraint [PDF]

International Journal of Robust and Nonlinear Control, 2010
AbstractWe consider the class of nonlinear systems in normal form with unitary relative degree whose zero and output dynamics are affected by state jumps fulfilling an average dwell‐time constraint. Under a minimum‐phase assumption requiring the existence of a compact set, which is globally pre‐asymptotically stable for the hybrid zero dynamics, we ...
A. R. Teel, MARCONI, LORENZO
openaire   +3 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Intra-arterial adenoviral mediated tumor transfection in a novel model of cancer gene therapy

Molecular Cancer, 2006
Background The aim of the present study was to develop and characterize a novel in vivo cancer gene therapy model in which intra-arterial adenoviral gene delivery can be characterized.
Siemionow Maria, DiCorleto Paul E, Porvasnik Stacy L, Cabrera Gustavo, Goldman Corey K   +4 more
doaj   +1 more source

Pet ownership-related differences in medical and long-term care costs among community-dwelling older Japanese.

PLoS ONE, 2023
This study examined the differences in medical and long-term care costs over 18 months between pet owners and non-owners among community-dwelling older Japanese. Pet ownership data were collected from 460 community-dwelling adults age 65 years and older.
Yu Taniguchi, Yuri Yokoyama, Tomoko Ikeuchi, Seigo Mitsutake, Hiroshi Murayama, Takumi Abe, Satoshi Seino, Hidenori Amano, Mariko Nishi, Yasuhiro Hagiwara, Shoji Shinkai, Akihiko Kitamura, Yoshinori Fujiwara   +12 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Validation of expanded form of lubben social network scale among community-dwelling geriatric population in India

Indian Journal of Community Medicine, 2022
Background: For assessing social networks in the elderly and the social support they receive and to predict social isolation, a proper valid and reliable short-scale screening tool is necessary. The present study aims to estimate the internal consistency
K Bincy, Muthunarayan Logaraj, V V Anatharaman   +2 more
doaj   +1 more source