Results 181 to 190 of about 6,635 (208)

Human minisatellites, repeat DNA instability and meiotic recombination

Electrophoresis, 1999
Minisatellites include some of the most variable loci in the human genome and are superb for dissecting processes of tandem repeat DNA instability. Single DNA molecule analysis has revealed different mutation processes operating in the soma and germline. Low-level somatic instability results in simple intra-allelic rearrangements.
Jeffreys, AJ, Barber, R, Bois, P, Buard, J, Dubrova, YE, Grant, G, Hollies, CR, May, CA, Neumann, R, Panayi, M, Ritchie, AE, Shone, AC, Signer, E, Stead, JD, Tamaki, K   +14 more
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Distribution of tandem repeat polymorphism within minisatellite MS621 (D5S110)

Annals of Human Genetics, 1996
SummaryThe minisatellite MS621 (D5S110) is a highly polymorphic tandem repeat locus which maps to the distal region of human chromosome 5p. Major repeat unit variants at D5S110 differ not by base substitutions but by differences in the repetition of an 11 bp sequence motif found within each repeat. The two major classes of repeat unit thus contain two (
Armour, JAL, Crosier, M, Jeffreys, AJ
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Nonradioactive Approach to Type DNA by Minisatellite Variant Repeats

, 1994
A nonradioactive approach was established to type DNA by minisatellite variant repeats (MVR). Sequence variation in the repeat units of rninisatellites were described by Jeffreys et al. 1990. The human minisatellite clone MS32 detects the hypervariable locus D1S8. The core sequence of this minisatellite is a 29 bp repeat unit. Approximately half of the
Anke Hinney, C. Luckenbach, Christine Dürr, S. Rodewyk, Roger Pöltl, H. Ritter   +5 more
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Minisatellite repeat coding as a digital approach to DNA typing

Nature, 1991
Most DNA typing systems used in forensic and legal medicine assay allelic length variation at tandem repetitive DNA regions such as minisatellites. A simple alternative approach that displays patterns of variant repeat units along minisatellite alleles is described here.
Jeffreys, AJ, MacLeod, A, Tamaki, K, Neil, DL, Monckton, DG   +4 more
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Human minisatellite loci composed of interspersed GGA-GGT triplet repeats

Proceedings of the Royal Society of London. Series B: Biological Sciences, 1995
We have isolated two tandemly repeated loci from human DNA which contain long blocks of GGA and GGT trinucleotide repeats. These two repeat unit types, together with other less common variants, are apparently irregularly interspersed along each repeat array.
Armour, JA, Crosier, M, Malcolm, S, Chan, JC, Jeffreys, AJ   +4 more
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Differences and similarities between various tandem repeat sequences: Minisatellites and microsatellites

Biochimie, 1997
Tandemly repetitive DNA sequences are abundantly interspersed in the genome of practically all eukaryotic species studied. The relative occurrence of one type of repetitive sequence and its location in the genome appear to be species specific. A common property of repetitive sequences within the living world is their ability to give rise to variants ...
H, Debrauwere, C G, Gendrel, S, Lechat, M, Dutreix   +3 more
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Minisatellite-like repeat sequences in the genome of rodent malaria parasites.

Acta Leidensia, 1992
Using minisatellite DNA probes and various Southern blots containing DNA samples from rodent malaria parasites it was shown that minisatellite-like sequences occur in the genome of these Plasmodium species. In contrast to the high copy number as observed in higher eukaryotes, the use of fingerprinting techniques on DNA from these parasites reveals that
A, van Belkum, G, Trommelen, A, Uitterlinden   +2 more
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Digital DNA typing at a second hypervariable locus by minisatellite variant repeat mapping

Human Molecular Genetics, 1993
Minisatellite variant repeat unit mapping by PCR (MVR-PCR) assays the interspersion pattern of variant repeat units along minisatellite alleles. Mapping such internal variation in the highly polymorphic minisatellite MS31A (locus D7S21), reveals extreme levels of allelic variability, far in excess of that detectable by allele length analysis.
D L, Neil, A J, Jeffreys
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Minisatellite variant repeat mapping: Application to DNA typing and mutation analysis

1993
Most DNA typing systems assay allele length variation at tandemly repeated loci such as minisatellites and microsatellites. Allele length measurements are approximate, which impedes the use of such loci in forensic analysis and in studies of allelic variability at hypervariable loci.
A J, Jeffreys, D G, Monckton, K, Tamaki, D L, Neil, J A, Armour, A, MacLeod, A, Collick, M, Allen, M, Jobling   +8 more
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Characterization of a minisatellite repeat locus in the chloroplast genome of Orchis palustris (Orchidaceae)

Current Genetics, 2001
We describe the occurrence of a tandem repeat in the chloroplast genome of the marsh orchid, Orchis palustris. The repeat unit is an AT-rich, 16-bp sequence located in the chloroplast tRNALEU intron. Southern blot analysis confirmed that the O. palustris tRNALEU intron including the minisatellite locus has not been transferred to the nucleus, but is ...
CAFASSO D., PELLEGRINO G., WIDMER A., MUSACCHIO A., COZZOLINO, SALVATORE   +4 more
openaire   +5 more sources