Results 11 to 20 of about 44,565 (245)

Autosomal minor histocompatibility antigens; How genetic variants create diversity in immune targets [PDF]

Frontiers in Immunology, 2016
Allogeneic hematopoietic stem cell transplantation (alloSCT) can be a curative treatment for hematological malignancies. Unfortunately, the desired anti-tumor or Graft-versus-Leukemia (GvL) effect is often accompanied with undesired side effects against ...
Marieke eGriffioen, Cornelis A.M. van Bergen, J.H.Frederik eFalkenburg   +2 more
doaj   +2 more sources

Identification of 4 novel HLA-B*40:01 restricted minor histocompatibility antigens and their potential as targets for graft-versus-leukemia reactivity [PDF]

Haematologica, 2012
Background Patients with hematologic malignancies can be successfully treated with donor lymphocyte infusion after HLA-matched allogeneic hematopoietic stem cell transplantation.
Marieke Griffioen, M. Willy Honders, Edith D. van der Meijden, Simone A.P. van Luxemburg-Heijs, Ellie G.A. Lurvink, Michel G.D. Kester, Cornelis A.M. van Bergen, J.H. Frederik Falkenburg   +7 more
doaj   +2 more sources

Phenotype frequencies of autosomal minor histocompatibility antigens display significant differences among populations. [PDF]

PLoS Genetics, 2007
Minor histocompatibility (H) antigens are allogeneic target molecules having significant roles in alloimmune responses after human leukocyte antigen-matched solid organ and stem cell transplantation (SCT).
Eric Spierings, Matthijs Hendriks, Léna Absi, Angelica Canossi, Sonal Chhaya, John Crowley, Harry Dolstra, Jean-François Eliaou, Tom Ellis, Jürgen Enczmann, Maria E Fasano, Thibaut Gervais, Clara Gorodezky, Brigitte Kircher, David Laurin, Mary S Leffell, Pascale Loiseau, Mari Malkki, Miroslaw Markiewicz, Miryam Martinetti, Etsuko Maruya, Narinder Mehra, Fatma Oguz, Machteld Oudshoorn, Noemi Pereira, Rajni Rani, Ruhena Sergeant, Jackie Thomson, Thuong Hien Tran, Hannu Turpeinen, Kuo-Liang Yang, Renata Zunec, Mary Carrington, Peter de Knijff, Els Goulmy   +34 more
doaj   +2 more sources

Determining the Quantitative Principles of T Cell Response to Antigenic Disparity in Stem Cell Transplantation [PDF]

Frontiers in Immunology, 2018
Alloreactivity compromising clinical outcomes in stem cell transplantation is observed despite HLA matching of donors and recipients. This has its origin in the variation between the exomes of the two, which provides the basis for minor ...
Ali Salman, Vishal Koparde, Charles E. Hall, Max Jameson-Lee, Catherine Roberts, Myrna Serrano, Badar AbdulRazzaq, Jeremy Meier, Caleb Kennedy, Masoud H. Manjili, Stephen R. Spellman, Dayanjan Wijesinghe, Shahrukh Hashmi, Greg Buck, Rehan Qayyum, Michael Neale, Jason Reed, Amir A. Toor   +17 more
doaj   +3 more sources

High-throughput identification of potential minor histocompatibility antigens by MHC tetramer-based screening: feasibility and limitations. [PDF]

PLoS ONE, 2011
T-cell recognition of minor histocompatibility antigens (MiHA) plays an important role in the graft-versus-tumor (GVT) effect of allogeneic stem cell transplantation (allo-SCT).
Pleun Hombrink, Sine R Hadrup, Arne Bakker, Michel G D Kester, J H Frederik Falkenburg, Peter A von dem Borne, Ton N M Schumacher, Mirjam H M Heemskerk   +7 more
doaj   +2 more sources

Prolonged Skin Graft Survival and Histocompatibility in Highly Inbred Miniature Swine [PDF]

Transplantation Direct
Background. Pigs are potential organ donors for humans. Some proposed xenotransplant tolerance regimens require genetically identical cells from different animals (eg, juvenile bone marrow and mature organs or tissues).
Elin Manell, DVM, PhD, Harko Mulder, MSc, J. Scott Arn, BS, Esad Gunes, MD, Ishit Chauhan, MD, Satyajit Patwardhan, MD, Julie Hong, MD, Ibrahim Batal, MD, David H. Sachs, MD, Joshua Weiner, MD   +9 more
doaj   +2 more sources

CD4 Donor Lymphocyte Infusion Can Cause Conversion of Chimerism Without GVHD by Inducing Immune Responses Targeting Minor Histocompatibility Antigens in HLA Class II [PDF]

Frontiers in Immunology, 2018
Under non-inflammatory conditions HLA class II is predominantly expressed on hematopoietic cells. Therefore, donor CD4 T-cells after allogeneic stem cell transplantation (alloSCT) may mediate graft-vs.-leukemia reactivity without graft-vs.-host disease ...
Peter van Balen, Cornelis A. M. van Bergen, Simone A. P. van Luxemburg-Heijs, Wendy de Klerk, Esther H. M. van Egmond, Sabrina A. J. Veld, Constantijn J. M. Halkes, Jaap-Jan Zwaginga, Jaap-Jan Zwaginga, Marieke Griffioen, Inge Jedema, J. H. Frederik Falkenburg   +11 more
doaj   +2 more sources

Human minor histocompatibility antigens

Transplant Immunology, 1993
For over five decades minor histocompatibility (mH) antigens have contmued to fascmate immimologists, mainly because of their minor but distinct role in transplantation but no less because of their as yet unknown nature In the 1970s lt became evident that mH antigens were recognized in a MHC restncted fashion, an important feature which was poorly ...
M, de Bueger, E, Goulmy
  +8 more sources

Minor histocompatibility antigens and the maternal immune response to the fetus during pregnancy. [PDF]

Am J Reprod Immunol, 2013
Linscheid C, Petroff MG.
europepmc   +2 more sources

T-Cell Immunotherapies Targeting Histocompatibility and Tumor Antigens in Hematological Malignancies

Frontiers in Immunology, 2020
Over the last decades, T-cell immunotherapy has revealed itself as a powerful, and often curative, strategy to treat blood cancers. In hematopoietic cell transplantation, most of the so-called graft-vs.-leukemia (GVL) effect hinges on the recognition of ...
Valérie Janelle, Caroline Rulleau, Simon Del Testa, Cédric Carli, Jean-Sébastien Delisle, Jean-Sébastien Delisle, Jean-Sébastien Delisle   +6 more
doaj   +1 more source