Results 11 to 20 of about 23,101 (249)

Identification of 4 novel HLA-B*40:01 restricted minor histocompatibility antigens and their potential as targets for graft-versus-leukemia reactivity [PDF]

Haematologica, 2012
Background Patients with hematologic malignancies can be successfully treated with donor lymphocyte infusion after HLA-matched allogeneic hematopoietic stem cell transplantation.
Marieke Griffioen, M. Willy Honders, Edith D. van der Meijden, Simone A.P. van Luxemburg-Heijs, Ellie G.A. Lurvink, Michel G.D. Kester, Cornelis A.M. van Bergen, J.H. Frederik Falkenburg   +7 more
doaj   +2 more sources

The immunogenomics of minor histocompatibility antigens.

Immunological Reviews, 2002
Minor histocompatibility (H) antigens are a diverse assemblage of major histocompatibility complex (MHC)-bound peptides with the unifying property of acting as alloantigens that induce allogeneic tissue rejection. They are a consequence of any form of
Derry Roopenian, Roopenian, D, Choi, E Y, Aaron Brown, Brown, A, Eun Young Choi   +5 more
core   +4 more sources

Minor histocompatibility antigens.

Current Opinion in Immunology, 1997
The existence of transplantation antigens, in addition to those encoded by genes in the MHC, has been known for over half a century. The molecular identification of these additional minor histocompatibility (H) antigens lagged behind that of their MHC
Roopenian, D C, Simpson, E
core   +4 more sources

High-throughput identification of potential minor histocompatibility antigens by MHC tetramer-based screening: feasibility and limitations. [PDF]

PLoS ONE, 2011
T-cell recognition of minor histocompatibility antigens (MiHA) plays an important role in the graft-versus-tumor (GVT) effect of allogeneic stem cell transplantation (allo-SCT).
Pleun Hombrink, Sine R Hadrup, Arne Bakker, Michel G D Kester, J H Frederik Falkenburg, Peter A von dem Borne, Ton N M Schumacher, Mirjam H M Heemskerk   +7 more
doaj   +2 more sources

A uniform genomic minor histocompatibility antigen typing methodology and database designed to facilitate clinical applications. [PDF]

PLoS ONE, 2006
BACKGROUND: Minor Histocompatibility (H) antigen mismatches significantly influence the outcome of HLA-matched allogeneic stem cell transplantation. The molecular identification of human H antigens is increasing rapidly. In parallel, clinical application
Eric Spierings, Jos Drabbels, Matthijs Hendriks, Jos Pool, Marijke Spruyt-Gerritse, Frans Claas, Els Goulmy   +6 more
doaj   +3 more sources

Prolonged Skin Graft Survival and Histocompatibility in Highly Inbred Miniature Swine [PDF]

Transplantation Direct
Background. Pigs are potential organ donors for humans. Some proposed xenotransplant tolerance regimens require genetically identical cells from different animals (eg, juvenile bone marrow and mature organs or tissues).
Elin Manell, DVM, PhD, Harko Mulder, MSc, J. Scott Arn, BS, Esad Gunes, MD, Ishit Chauhan, MD, Satyajit Patwardhan, MD, Julie Hong, MD, Ibrahim Batal, MD, David H. Sachs, MD, Joshua Weiner, MD   +9 more
doaj   +2 more sources

Minors come of age: minor histocompatibility antigens and graft-versus-host disease

Biology of Blood and Marrow Transplantation, 2004
Minor histocompatibility antigens (miHA) are responsible for the occurrence of graft-versus-host disease in the setting of a major histocompatibility complex matched sibling allogeneic stem cell transplantation.
Nelson J Chao, Chao, Nelson J
exaly   +2 more sources

The Connection Between Minor H Antigens and Neoantigens and the Missing Link in Their Prediction

Frontiers in Immunology, 2020
For hundreds of thousands of years, the human genome has extensively evolved, resulting in genetic variations in almost every gene. Immunological reflections of these genetic variations become clearly visible after an allogeneic stem cell transplantation
Tuna Mutis, Anastasia Xagara, Anastasia Xagara, Robbert M. Spaapen, Robbert M. Spaapen   +4 more
doaj   +2 more sources

Minor Histocompatibility antigens in GvL.

, 2000
In syngeneic bone marrow transplantation (BMT) and in recipients of autologous BMT, relapse rates are high. No MHC or minor histocompatibility antigen (mHag) disparities exist and thus no alloreactivities can be induced.
Goulmy, E.A.J.M., Mutis, T., Goulmy, Els, Mutis, Tuna   +3 more
core   +7 more sources

The genetic origin of minor histocompatibility antigens.

Immunogenetics, 1993
The purpose of this study was to elucidate the genetic origin of minor histocompatibility (H) antigens. Toward this end common inbred mouse strains, distinct subspecies, and species of the subgenus Mus were examined for expression of various minor H ...
Zuberi, A R, Christianson, G J, Davis, A P, Mobraaten, L E, Roopenian, D C   +4 more
core   +4 more sources