Results 21 to 30 of about 861,631 (245)

Minor Histocompatibility Antigen-Specific T Cells

Frontiers in Pediatrics, 2020
Minor Histocompatibility (H) antigens are major histocompatibility complex (MHC)/Human Leukocyte Antigen (HLA)-bound peptides that differ between allogeneic hematopoietic stem cell transplantation (HCT) recipients and their donors as a result of genetic ...
Corinne Summers, Corinne Summers, Vipul S. Sheth, Marie Bleakley, Marie Bleakley   +4 more
doaj   +1 more source

T-Cell Immunotherapies Targeting Histocompatibility and Tumor Antigens in Hematological Malignancies

Frontiers in Immunology, 2020
Over the last decades, T-cell immunotherapy has revealed itself as a powerful, and often curative, strategy to treat blood cancers. In hematopoietic cell transplantation, most of the so-called graft-vs.-leukemia (GVL) effect hinges on the recognition of ...
Valérie Janelle, Caroline Rulleau, Simon Del Testa, Cédric Carli, Jean-Sébastien Delisle, Jean-Sébastien Delisle, Jean-Sébastien Delisle   +6 more
doaj   +1 more source

Discovery and Differential Processing of HLA Class II-Restricted Minor Histocompatibility Antigen LB-PIP4K2A-1S and Its Allelic Variant by Asparagine Endopeptidase

Frontiers in Immunology, 2020
Minor histocompatibility antigens are the main targets of donor-derived T-cells after allogeneic stem cell transplantation. Identification of these antigens and understanding their biology are a key requisite for more insight into how graft vs.
Anita N. Kremer, Judith Bausenwein, Ellie Lurvink, Andreas E. Kremer, Caroline E. Rutten, Cornelis A. M. van Bergen, Sascha Kretschmann, Edith van der Meijden, Maria W. Honders, Daniela Mazzeo, Colin Watts, Andreas Mackensen, J. H. Frederik Falkenburg, Marieke Griffioen   +13 more
doaj   +1 more source

Human minor histocompatibility antigens

Transplant Immunology, 1993
For over five decades minor histocompatibility (mH) antigens have contmued to fascmate immimologists, mainly because of their minor but distinct role in transplantation but no less because of their as yet unknown nature In the 1970s lt became evident that mH antigens were recognized in a MHC restncted fashion, an important feature which was poorly ...
M, de Bueger, E, Goulmy
openaire   +5 more sources

The Connection Between Minor H Antigens and Neoantigens and the Missing Link in Their Prediction

Frontiers in Immunology, 2020
For hundreds of thousands of years, the human genome has extensively evolved, resulting in genetic variations in almost every gene. Immunological reflections of these genetic variations become clearly visible after an allogeneic stem cell transplantation
Tuna Mutis, Anastasia Xagara, Anastasia Xagara, Robbert M. Spaapen, Robbert M. Spaapen   +4 more
doaj   +1 more source

Prognostic significance of tumor microenvironment assessed by machine learning algorithm in surgically resected non‐small cell lung cancer

Cancer Reports, EarlyView., 2023
Abstract Background A methodology to assess the immune microenvironment (IME) of non‐small cell lung cancer (NSCLC) has not been established, and the prognostic impact of IME factors is not yet clear. Aims This study aimed to assess the IME factors and evaluate their prognostic values. Methods and Results We assessed CD8+ tumor‐infiltrating lymphocyte (
Yukihiro Terada, Mitsuhiro Isaka, Akira Ono, Takuya Kawata, Masakuni Serizawa, Keita Mori, Koji Muramatsu, Kiyoshi Tone, Hirotsugu Kenmotsu, Keiichi Ohshima, Kenichi Urakami, Takeshi Nagashima, Masatoshi Kusuhara, Yasuto Akiyama, Takashi Sugino, Toshiaki Takahashi, Yasuhisa Ohde   +16 more
wiley   +1 more source

Identification of 4 novel HLA-B*40:01 restricted minor histocompatibility antigens and their potential as targets for graft-versus-leukemia reactivity

Haematologica, 2012
Background Patients with hematologic malignancies can be successfully treated with donor lymphocyte infusion after HLA-matched allogeneic hematopoietic stem cell transplantation.
Marieke Griffioen, M. Willy Honders, Edith D. van der Meijden, Simone A.P. van Luxemburg-Heijs, Ellie G.A. Lurvink, Michel G.D. Kester, Cornelis A.M. van Bergen, J.H. Frederik Falkenburg   +7 more
doaj   +1 more source

A uniform genomic minor histocompatibility antigen typing methodology and database designed to facilitate clinical applications. [PDF]

PLoS ONE, 2006
BACKGROUND: Minor Histocompatibility (H) antigen mismatches significantly influence the outcome of HLA-matched allogeneic stem cell transplantation. The molecular identification of human H antigens is increasing rapidly. In parallel, clinical application
Eric Spierings, Jos Drabbels, Matthijs Hendriks, Jos Pool, Marijke Spruyt-Gerritse, Frans Claas, Els Goulmy   +6 more
doaj   +1 more source

Enhancement of Antigen Presentation by Deletion of Viral Immune Evasion Genes Prevents Lethal Cytomegalovirus Disease in Minor Histocompatibility Antigen-Mismatched Hematopoietic Cell Transplantation

Frontiers in Cellular and Infection Microbiology, 2020
Hematoablative treatment followed by hematopoietic cell transplantation (HCT) for reconstituting the co-ablated immune system is a therapeutic option to cure aggressive forms of hematopoietic malignancies.
Emin Gezinir, Jürgen Podlech, Kerstin M. Gergely, Sara Becker, Matthias J. Reddehase, Niels A. W. Lemmermann   +5 more
doaj   +1 more source

CHARACTERIZATION OF MINOR HISTOCOMPATIBILITY ANTIGENS AND THEIR ROLE IN ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION: SINGLE CENTER EXPERIENCE IN TURKIYE

Sabiad, 2022
Objective: The minor histocompatibility antigens (mHAgs) are the epitopes composed of polymorphic essential peptides, and they create T cell response limited to a variety of class I and II HLA alleles.
Fatma Savran Oğuz, Çiğdem Kekik Çınar, Süleyman Rüştü Oğuz, Demet Kıvanç İzgi, Fatma Deniz Sargın, Sevgi Kalayoğlu Beşışık   +5 more
doaj   +1 more source