Results 31 to 40 of about 23,170 (228)

Enhancement of Antigen Presentation by Deletion of Viral Immune Evasion Genes Prevents Lethal Cytomegalovirus Disease in Minor Histocompatibility Antigen-Mismatched Hematopoietic Cell Transplantation

Frontiers in Cellular and Infection Microbiology, 2020
Hematoablative treatment followed by hematopoietic cell transplantation (HCT) for reconstituting the co-ablated immune system is a therapeutic option to cure aggressive forms of hematopoietic malignancies.
Emin Gezinir, Jürgen Podlech, Kerstin M. Gergely, Sara Becker, Matthias J. Reddehase, Niels A. W. Lemmermann   +5 more
doaj   +1 more source

CHARACTERIZATION OF MINOR HISTOCOMPATIBILITY ANTIGENS AND THEIR ROLE IN ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION: SINGLE CENTER EXPERIENCE IN TURKIYE

Sabiad, 2022
Objective: The minor histocompatibility antigens (mHAgs) are the epitopes composed of polymorphic essential peptides, and they create T cell response limited to a variety of class I and II HLA alleles.
Fatma Savran Oğuz, Çiğdem Kekik Çınar, Süleyman Rüştü Oğuz, Demet Kıvanç İzgi, Fatma Deniz Sargın, Sevgi Kalayoğlu Beşışık   +5 more
doaj   +1 more source

Minor histocompatibility antigens are expressed in syncytiotrophoblast and trophoblast debris: implications for maternal alloreactivity to the fetus. [PDF]

Am J Pathol, 2012
The fetal semi-allograft can induce expansion and tolerance of antigen-specific maternal T and B cells through paternally inherited major histocompatibility complex and minor histocompatibility antigens (mHAgs).
Holland OJ, Linscheid C, Hodes HC, Nauser TL, Gilliam M, Stone P, Chamley LW, Petroff MG.   +7 more
europepmc   +2 more sources

Suppression extends to major histocompatibility antigens linked to tolerizing minor histocompatibility antigens, but not the other way round [PDF]

, 2005
'Active suppression', a mechanism of transplantation tolerance, can spread to newly introduced minor antigens once these antigens are linked to tolerizing antigens.
Schellekens, Peter, Bemelman, Frederike, Yong, Si-La, Tissingh, Rudi, ten Berge, Ineke   +4 more
core   +1 more source

Table_2_Optimized Whole Genome Association Scanning for Discovery of HLA Class I-Restricted Minor Histocompatibility Antigens.xlsx [PDF]

, 2020
Patients undergoing allogeneic stem cell transplantation as treatment for hematological diseases face the risk of Graft-versus-Host Disease as well as relapse. Graft-versus-Host Disease and the favorable Graft-versus-Leukemia effect are mediated by donor
J. H. Frederik Falkenburg (8558778), Marieke Griffioen (119817), Dyantha I. van der Lee (3115227), Szymon M. Kielbasa (8722956), Margot J. Pont (3115230), M. Willy Honders (8722947), Kyra J. Fuchs (8722944), Ramin Monajemi (6874238), Edith D. van der Meijden (8722950), Alwin E. Adriaans (8722953), Cornelis A. M. van Bergen (5657533), Peter A. C. ’t Hoen (8722959)   +11 more
core   +1 more source

Cell-based therapy in prophylaxis and treatment of chronic graft-versus-host disease

Frontiers in Immunology, 2022
Hematopoietic allogeneic stem cell transplantation (allo-SCT) is a curative option for patients with hematological malignancies. However, due to disparities in major and minor histocompatibility antigens between donor and recipient, severe inflammatory ...
Matteo Doglio, Rachel E. Crossland, Ana C. Alho, Ana C. Alho, Olaf Penack, Anne M. Dickinson, Anne M. Dickinson, Georg Stary, Georg Stary, Georg Stary, João F. Lacerda, João F. Lacerda, Günther Eissner, Marit Inngjerdingen   +13 more
doaj   +1 more source

Molecular modeling of an antigenic complex between a viral peptide and a class I major histocompatibility glycoprotein [PDF]

, 1992
Computer simulation of the conformations of short antigenic peptides (&lo residues) either free or bound to their receptor, the major histocompatibility complex (MHC)- encoded glycoprotein H-2 Ld, was employed to explain experimentally determined ...
Reddehase, Matthias J., Rognan, Didier, Koszinowski, Ulrich H., Folkers, Gerd, Gerd Folkers, Didier Rognan, Matthias J. Reddehase, Ulrich H. Koszinowski   +7 more
core   +1 more source

Table_3_Optimized Whole Genome Association Scanning for Discovery of HLA Class I-Restricted Minor Histocompatibility Antigens.xlsx [PDF]

, 2020
Patients undergoing allogeneic stem cell transplantation as treatment for hematological diseases face the risk of Graft-versus-Host Disease as well as relapse. Graft-versus-Host Disease and the favorable Graft-versus-Leukemia effect are mediated by donor
J. H. Frederik Falkenburg (8558778), Marieke Griffioen (119817), Dyantha I. van der Lee (3115227), Szymon M. Kielbasa (8722956), Margot J. Pont (3115230), M. Willy Honders (8722947), Kyra J. Fuchs (8722944), Ramin Monajemi (6874238), Edith D. van der Meijden (8722950), Alwin E. Adriaans (8722953), Cornelis A. M. van Bergen (5657533), Peter A. C. ’t Hoen (8722959)   +11 more
core   +1 more source

Genome-Wide Analysis in Swine Associates Corneal Graft Rejection with Donor-Recipient Mismatches in Three Novel Histocompatibility Regions and One Locus Homologous to the Mouse H-3 Locus.

PLoS ONE, 2016
In rodents, immune responses to minor histocompatibility antigens are the most important drivers of corneal graft rejection. However, this has not been confirmed in humans or in a large animal model and the genetic loci are poorly characterised, even in ...
Susan Nicholls, Ricardo Pong-Wong, Louisa Mitchard, Ross Harley, Alan Archibald, Andrew Dick, Michael Bailey   +6 more
doaj   +1 more source

Clinical relevance of minor histocompatibility antigens [PDF]

, 2019
Conference Conference: 10th Eurasian Hematology Oncology Congress Location: Istanbul, TURKEY Date: OCT 08-11, 2019Objective: The minor histocompatibility antigens (MiHA) are epitopes composed of polymorphic essential peptides evoking alloimmune ...
Savran Oğuz, Fatma, Kekik Çınar, Çiğdem, Oğuz, Seda B., Sargın, Deniz, Kalayoğlu Beşışık, Sevgi   +4 more
core   +1 more source