Results 31 to 40 of about 23,101 (249)
Frontiers in Cellular and Infection Microbiology, 2020 Hematoablative treatment followed by hematopoietic cell transplantation (HCT) for reconstituting the co-ablated immune system is a therapeutic option to cure aggressive forms of hematopoietic malignancies.
Emin Gezinir +5 more
doaj +1 more source
Sabiad, 2022 Objective: The minor histocompatibility antigens (mHAgs) are the epitopes composed of polymorphic essential peptides, and they create T cell response limited to a variety of class I and II HLA alleles.
Fatma Savran Oğuz +5 more
doaj +1 more source
Cell-based therapy in prophylaxis and treatment of chronic graft-versus-host disease
Frontiers in Immunology, 2022 Hematopoietic allogeneic stem cell transplantation (allo-SCT) is a curative option for patients with hematological malignancies. However, due to disparities in major and minor histocompatibility antigens between donor and recipient, severe inflammatory ...
Matteo Doglio +13 more
doaj +1 more source
Molecular modeling of an antigenic complex between a viral peptide and a class I major histocompatibility glycoprotein [PDF]
, 1992 Computer simulation of the conformations of short antigenic peptides (&lo residues) either free or bound to their receptor, the major histocompatibility complex (MHC)- encoded glycoprotein H-2 Ld, was employed to explain experimentally determined ...
Reddehase, Matthias J. +7 more
core +1 more source
PLoS ONE, 2016 In rodents, immune responses to minor histocompatibility antigens are the most important drivers of corneal graft rejection. However, this has not been confirmed in humans or in a large animal model and the genetic loci are poorly characterised, even in ...
Susan Nicholls +6 more
doaj +1 more source
Expanding the immunotherapeutic potential of minor histocompatibility antigens. [PDF]
J Clin Invest, 2005 Minor histocompatibility antigens (mHAgs) selectively expressed by cells or cell subsets of the hematopoietic system are targets of the T cell-mediated graft-versus-leukemia response that develops following allogeneic hematopoietic stem cell transplantation (HSCT) for the treatment of hematological malignancies.
Spierings E, Goulmy E.
europepmc +4 more sources
Viruses, 2021 Hematopoietic cell (HC) transplantation (HCT) is the last resort to cure hematopoietic malignancies that are refractory to standard therapies. Hematoablative treatment aims at wiping out tumor cells as completely as possible to avoid leukemia/lymphoma ...
Matthias J. Reddehase +2 more
doaj +1 more source
HLA class I-restricted minor histocompatibility antigens.
, 2016 HLA class I-restricted minor histocompatibility antigens.
Marieke Griffioen (119817) +3 more
core +1 more source
Post‐Translational Isoaspartate Promotes Amyloid Formation in β2‐Microglobulin
Angewandte Chemie, EarlyView.Chemical synthesis of five β2‐microglobulin (β2m) variants reveals the structural impact of Asn deamidation. By introducing Asp or isoAsp at susceptible Asn‐Gly sequences, we demonstrate that isoAsp17 formation specifically accelerates amyloid fibril formation, highlighting its potential contribution to dialysis‐related amyloidosis.
Ryuji Kawakami +5 more
wiley +2 more sources
In silico analysis of minor histocompatibility antigens.
, 2016 In silico analysis of minor histocompatibility antigens.
Marieke Griffioen (119817) +3 more
core +1 more source