Results 51 to 60 of about 23,170 (228)

A glow of HLA typing in organ transplantation

Clinical and Translational Medicine, 2013
The transplant of organs and tissues is one of the greatest curative achievements of this century. In organ transplantation, the adaptive immunity is considered the main response exerted to the transplanted tissue, since the main goal of the immune ...
Batool Mutar Mahdi
doaj   +1 more source

CLINICALLY RELEVANT MINOR HISTOCOMPATIBILITY ANTIGENS FOR RUSSIAN PATIENTS UNDERGOING HEMATOPOIETIC STEM CELL TRANSPLANTATION

Медицинская иммунология, 2019
Hematopoietic stem cell transplantation (HSCT) from healthy donors is used for blood cancer treatment. Alloreactive graft-versus-host disease (GvHD) is one of the post-transplant detrimental side effects, and the main reason for GVHD after HSCT fully ...
D. S. Romaniuk, A. A. Khmelevskaya, A. M. Postovskaya, D. B. Malko, E. P. Kuzminova, E. G. Khamaganova, G. A. Efimov   +6 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Genetic engineering of virus-specific T cells with T-cell receptors recognizing minor histocompatibility antigens for clinical application

Haematologica, 2008
Background Donor lymphocyte infusion is an effective form of adoptive immunotherapy for hematologic malignancies after allogeneic stem cell transplantation.
Marieke Griffioen, H.M. Esther van Egmond, Helen Barnby-Porritt, Menno A.W.G. van der Hoorn, Renate S. Hagedoorn, Michel G.D. Kester, Nikolai Schwabe, Roel Willemze, J.H. Frederik Falkenburg, Mirjam H.M. Heemskerk   +9 more
doaj   +1 more source

Engineering Immunoregenerative Therapy via an Immunomodulatory Binary Pharmacology Hydrogel Depot for Prolonged Allograft Survival

Advanced Science, EarlyView.
An immunomodulatory hydrogel (iGEL) forms spontaneously upon subcutaneous injection, acting as a tissue‐adhesive depot. It releases anti‐rejection and regenerative agents in response to inflammation, suppressing T‐cell activity, promoting vascular repair, and restoring allograft function without systemic immunosuppression.
Ning Wang, Ruiqi Sun, Yang Fu, Zhonghan Wu, Xinyu Tong, Hong Tang, Wentao Zhao, Zhi Liang, Jintao Zheng, Yanan Guan, Ke Zhou, Penghong Song, Shusen Zheng, Hangxiang Wang, Haiyang Xie   +14 more
wiley   +1 more source

Tolerogenic effect of noninherited maternal antigens in hematopoietic stem cell transplantation

Frontiers in Immunology, 2012
Major histocompatibility complex antigens that provoke severe transplant reactions are referred to as the human leukocyte antigen (HLA) in human and as the H-2 in mice.
Masahiro eHirayama, Eiichi eAzuma, Yoshihiro eKomada   +2 more
doaj   +1 more source

Identifying a Minor Histocompatibility Antigen in Mauritian Cynomolgus Macaques Encoded by APOBEC3C

Frontiers in Immunology, 2020
Allogeneic hematopoietic stem cell transplants can lead to dramatic reductions in human immunodeficiency virus (HIV) reservoirs. This effect is partially mediated by donor T cells recognizing lymphocyte-expressed minor histocompatibility antigens (mHAgs).
Jason T. Weinfurter, Michael E. Graham, Adam J. Ericsen, Lea M. Matschke, Sian Llewellyn-Lacey, David A. Price, David A. Price, Roger W. Wiseman, Matthew R. Reynolds, Matthew R. Reynolds   +9 more
doaj   +1 more source

Dual Lineages of Langerhans Cells Cooperate to Restore the Immune Barrier after Skin Injury

Advanced Science, EarlyView.
After skin injury, the epidermal immune barrier is rebuilt by two sources of Langerhans cells. Resident Langerhans cells first move into the wound during re‐epithelialization, guided by CXCR2 signaling. Later, recruited monocytes become long‐lived Langerhans cells.
Axel D. Schmitter‐Sánchez, Nicholas Basista, Sudhanshu Mishra, Hyeri Kim, Audrey Bench, Catherine Matte‐Martone, Min‐Soo Seo, Gun Woo Lee, Sangbum Park   +8 more
wiley   +1 more source

The Expression of Sex-Specific and Autosomal Minor Histocompatibility Antigens by the Placenta [PDF]

, 2013
Full text is available to authenticated members of The University of Auckland only.Introduction: Minor histocompatibility antigens were identified as causing organ transplant rejection in HLAmatched donor/recipient pairs (1).
Gamage, Teena
core  

In Search of Immunodominant Minor Histocompatibility Antigens [PDF]

Biology of Blood and Marrow Transplantation, 2013
survival. Larger retrospective studies should parse out relapse risk in specific cytogenetic subgroups, to offer more guidance to the practicing clinician. Our hope is that this and other retrospective studies of MRD monitoring leads to an assessment of the prognostic impact of MRD in well-defined molecular and cytogenetic subsets of AML.
openaire   +2 more sources