Results 51 to 60 of about 23,101 (249)

Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion

Advanced Science, EarlyView.
The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li, Yuanxin Li, Asif Rashid, Hong Kee Tan, Shing Chan, Man Yan Hui, Wilson Yau Ki Chan, Kee See Lam, Yinping Liu, Wenwei Tu, Wing Leung   +10 more
wiley   +1 more source

Suppression extends to major histocompatibility antigens linked to tolerizing minor histocompatibility antigens, but not the other way round

, 2005
'Active suppression', a mechanism of transplantation tolerance, can spread to newly introduced minor antigens once these antigens are linked to tolerizing antigens.
Schellekens, Peter, Bemelman, Frederike, Yong, Si-La, Tissingh, Rudi, ten Berge, Ineke   +4 more
core   +1 more source

In Search of Immunodominant Minor Histocompatibility Antigens [PDF]

Biology of Blood and Marrow Transplantation, 2013
survival. Larger retrospective studies should parse out relapse risk in specific cytogenetic subgroups, to offer more guidance to the practicing clinician. Our hope is that this and other retrospective studies of MRD monitoring leads to an assessment of the prognostic impact of MRD in well-defined molecular and cytogenetic subsets of AML.
openaire   +2 more sources

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Successful generation of primary virus-specific and anti-tumor T-cell responses from the naïve donor T-cell repertoire is determined by the balance between antigen-specific precursor T cells and regulatory T cells

Haematologica, 2011
Background One of the major challenges in allogeneic stem cell transplantation is to find a balance between the harmful induction of graft-versus-host disease and the beneficial graft-versus-leukemia and pathogen-specific immune responses.
Inge Jedema, Marian van de Meent, Jeanette Pots, Michel G.D. Kester, Martha T. van der Beek, J.H. Frederik Falkenburg   +5 more
doaj   +1 more source

Microarray Gene Expression Analysis to Evaluate Cell Type Specific Expression of Targets Relevant for Immunotherapy of Hematological Malignancies. [PDF]

PLoS ONE, 2016
Cellular immunotherapy has proven to be effective in the treatment of hematological cancers by donor lymphocyte infusion after allogeneic hematopoietic stem cell transplantation and more recently by targeted therapy with chimeric antigen or T-cell ...
M J Pont, M W Honders, A N Kremer, C van Kooten, C Out, P S Hiemstra, H C de Boer, M J Jager, E Schmelzer, R G Vries, A S Al Hinai, W G Kroes, R Monajemi, J J Goeman, S Böhringer, W A F Marijt, J H F Falkenburg, M Griffioen   +17 more
doaj   +1 more source

Table_2_Optimized Whole Genome Association Scanning for Discovery of HLA Class I-Restricted Minor Histocompatibility Antigens.xlsx

, 2020
Patients undergoing allogeneic stem cell transplantation as treatment for hematological diseases face the risk of Graft-versus-Host Disease as well as relapse. Graft-versus-Host Disease and the favorable Graft-versus-Leukemia effect are mediated by donor
J. H. Frederik Falkenburg (8558778), Marieke Griffioen (119817), Dyantha I. van der Lee (3115227), Szymon M. Kielbasa (8722956), Margot J. Pont (3115230), M. Willy Honders (8722947), Kyra J. Fuchs (8722944), Ramin Monajemi (6874238), Edith D. van der Meijden (8722950), Alwin E. Adriaans (8722953), Cornelis A. M. van Bergen (5657533), Peter A. C. ’t Hoen (8722959)   +11 more
core   +1 more source

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

Possible NK cell-mediated immune responses against iPSC-derived cells in allogeneic transplantation settings

Inflammation and Regeneration, 2021
In the regenerative medicine field, allogenic transplantation of regenerated tissues has been promoted because autologous transplantation setting is costly and time-consuming to prepare and therefore unsuitable for emergent treatment.
Kyoko Masuda, Hiroshi Kawamoto
doaj   +1 more source

Table_3_Optimized Whole Genome Association Scanning for Discovery of HLA Class I-Restricted Minor Histocompatibility Antigens.xlsx

, 2020
Patients undergoing allogeneic stem cell transplantation as treatment for hematological diseases face the risk of Graft-versus-Host Disease as well as relapse. Graft-versus-Host Disease and the favorable Graft-versus-Leukemia effect are mediated by donor
J. H. Frederik Falkenburg (8558778), Marieke Griffioen (119817), Dyantha I. van der Lee (3115227), Szymon M. Kielbasa (8722956), Margot J. Pont (3115230), M. Willy Honders (8722947), Kyra J. Fuchs (8722944), Ramin Monajemi (6874238), Edith D. van der Meijden (8722950), Alwin E. Adriaans (8722953), Cornelis A. M. van Bergen (5657533), Peter A. C. ’t Hoen (8722959)   +11 more
core   +1 more source