Results 61 to 70 of about 861,631 (245)

Microarray Gene Expression Analysis to Evaluate Cell Type Specific Expression of Targets Relevant for Immunotherapy of Hematological Malignancies. [PDF]

PLoS ONE, 2016
Cellular immunotherapy has proven to be effective in the treatment of hematological cancers by donor lymphocyte infusion after allogeneic hematopoietic stem cell transplantation and more recently by targeted therapy with chimeric antigen or T-cell ...
M J Pont, M W Honders, A N Kremer, C van Kooten, C Out, P S Hiemstra, H C de Boer, M J Jager, E Schmelzer, R G Vries, A S Al Hinai, W G Kroes, R Monajemi, J J Goeman, S Böhringer, W A F Marijt, J H F Falkenburg, M Griffioen   +17 more
doaj   +1 more source

Suppression extends to major histocompatibility antigens linked to tolerizing minor histocompatibility antigens, but not the other way round

, 2005
'Active suppression', a mechanism of transplantation tolerance, can spread to newly introduced minor antigens once these antigens are linked to tolerizing antigens.
Schellekens, Peter, Bemelman, Frederike, Yong, Si-La, Tissingh, Rudi, ten Berge, Ineke   +4 more
core   +1 more source

SynNotch Receptors for Visualizing Immunoreceptor Force Transmission and Downstream Signaling In Vivo

Advanced Science, EarlyView.
A mechanically activated SynNotch reporter platform enables detection of force transmission through receptors as they mediate immune cell interactions. Targeting CD40 on B cells and TCR on T cells records force‐induced reporter activation across 2D coculture, 3D organoid, and implanted in mice, which also reveal force‐amplification of immune receptor ...
Menglan Li, Jintian Lyu, Kaitao Li, Ameya Dravid, Deepali Balasubramani, Amir H. K. Ashkezari, Hyun‐Kyu Choi, Gabriel A. Kwong, Ankur Singh, Cheng Zhu   +9 more
wiley   +1 more source

Possible NK cell-mediated immune responses against iPSC-derived cells in allogeneic transplantation settings

Inflammation and Regeneration, 2021
In the regenerative medicine field, allogenic transplantation of regenerated tissues has been promoted because autologous transplantation setting is costly and time-consuming to prepare and therefore unsuitable for emergent treatment.
Kyoko Masuda, Hiroshi Kawamoto
doaj   +1 more source

High-throughput minor histocompatibility antigen prediction [PDF]

Bioinformatics, 2009
Abstract Motivation: Minor histocompatibility antigens (mHags) are a diverse collection of MHC-bound peptides that have immunological implications in the context of allogeneic transplantation because of their differential presence in donor and host, and thus play a critical role in the induction of the detrimental graft-versus-host ...
David S. DeLuca, Britta Eiz-Vesper, Nektarios Ladas, Barbara Anna-Maria Khattab, Rainer Blasczyk   +4 more
openaire   +2 more sources

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

Antigen-specific priming is dispensable in depletion of apoptosis-sensitive T cells for GvHD prophylaxis

Frontiers in Immunology, 2014
Prophylactic approaches to graft versus host disease (GvHD) have employed both phenotypic reduction of T cells and selective elimination of host-primed donor T cells in vitro and in vivo.
Shai eYarkoni, Jerry eStein, Isaac eYaniv, Nadir eAskenasy   +3 more
doaj   +1 more source

Clinical relevance of minor histocompatibility antigens

, 2019
Conference Conference: 10th Eurasian Hematology Oncology Congress Location: Istanbul, TURKEY Date: OCT 08-11, 2019Objective: The minor histocompatibility antigens (MiHA) are epitopes composed of polymorphic essential peptides evoking alloimmune ...
Savran Oğuz, Fatma, Kekik Çınar, Çiğdem, Oğuz, Seda B., Sargın, Deniz, Kalayoğlu Beşışık, Sevgi   +4 more
core   +1 more source

CAR‐Engineered Cell Therapies Beyond Cancer: Reprogramming Fibrosis and Immune‐Mediated Inflammation

Advanced Science, EarlyView.
CAR‐engineered cell therapies are expanding beyond cancer toward immune resetting, pathological‐cell clearance, matrix remodeling, and microenvironmental reprogramming in autoimmune, inflammatory, and fibrotic diseases. This Review compares CAR‐T, CAR‐macrophage, and CAR‐NK platforms and proposes controllable spatiotemporal reprogramming to align ...
Peng Jun Xu, Zhou Jing Zhang, Jing Jin, Hai Yuan Xu, Ya Xin Gu, Qian Qian Yang, You Lang Zhou   +6 more
wiley   +1 more source

IMMUNOBIOLOGY OF ACUTE GRAFT-VERSUS-HOST DISEASE

Медицинская иммунология, 2016
Transplantation of allogeneic hematopoietic stem cells is the only curative option for a number of diseases of hematopoietic system. It is intended to replace the hematopoietic system of the recipient withthe donor’s.
G. A. Efimov, A. S. Vdovin, A. A. Grigoryev, S. Yu. Filkin, N. A. Bykova, V. G. Savchenko   +5 more
doaj   +1 more source