Results 61 to 70 of about 23,101 (249)

Multiplex Genotyping of Human Minor Histocompatibility Antigens

Human Immunology, 2005
Minor histocompatibility antigens (mHAg) induce major histocompatibility complex-restricted, T cell-mediated immune responses that may contribute to increased risk of graft-versus-host disease and graft-versus-leukemia effects. Unlike human leukocyte antigen genes, mHAg are encoded by genetically and functionally unrelated genes located throughout the ...
Pietz, B.C., DuChateau, B.K., Warden, M.B., Ellis, T.M.   +3 more
openaire   +2 more sources

Nano‐Enabled Systemic Delivery of STING Agonist by Engineered Silicasome for Potent Antitumor Immunotherapy

Advanced Science, EarlyView.
Engineered mesoporous silica nanoparticles (Silicasomes) enable systemic delivery of the STING agonist ADU‐S100, overcoming the instability and toxicity that limit cyclic dinucleotides to local administration. By enhancing tumor accumulation, activating systemic antitumor immunity, and remodeling the tumor immune microenvironment, these nanoparticles ...
Wenjing Zhou, Yuting Li, Xudong Sun, Honghong Yang, Xiayu Shi, Lijia Yao, Jinhong Jiang, Erli Wang, Haoyang Wang, Yi Wei, Xiangsheng Liu   +10 more
wiley   +1 more source

In Silico Analysis of the Minor Histocompatibility Antigen Landscape Based on the 1000 Genomes Project

Frontiers in Immunology, 2018
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is routinely used to treat hematopoietic malignancies. The eradication of residual tumor cells during engraftment is mediated by donor cytotoxic T lymphocytes reactive to alloantigens.
Nadia A. Bykova, Dmitry B. Malko, Grigory A. Efimov   +2 more
doaj   +1 more source

Clinical relevance of minor histocompatibility antigens

, 2019
Conference Conference: 10th Eurasian Hematology Oncology Congress Location: Istanbul, TURKEY Date: OCT 08-11, 2019Objective: The minor histocompatibility antigens (MiHA) are epitopes composed of polymorphic essential peptides evoking alloimmune ...
Savran Oğuz, Fatma, Kekik Çınar, Çiğdem, Oğuz, Seda B., Sargın, Deniz, Kalayoğlu Beşışık, Sevgi   +4 more
core   +1 more source

Table_5_Optimized Whole Genome Association Scanning for Discovery of HLA Class I-Restricted Minor Histocompatibility Antigens.xlsx

, 2020
Patients undergoing allogeneic stem cell transplantation as treatment for hematological diseases face the risk of Graft-versus-Host Disease as well as relapse. Graft-versus-Host Disease and the favorable Graft-versus-Leukemia effect are mediated by donor
J. H. Frederik Falkenburg (8558778), Marieke Griffioen (119817), Dyantha I. van der Lee (3115227), Szymon M. Kielbasa (8722956), Margot J. Pont (3115230), M. Willy Honders (8722947), Kyra J. Fuchs (8722944), Ramin Monajemi (6874238), Edith D. van der Meijden (8722950), Alwin E. Adriaans (8722953), Cornelis A. M. van Bergen (5657533), Peter A. C. ’t Hoen (8722959)   +11 more
core   +1 more source

T‐Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan‐Cancer Characteristics, and Therapeutic Interventions

Advanced Science, EarlyView.
This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang, Wanhui Dong, Jian Chen, Zhangjie Zhou, Shujuan Fu, Tingting Wu, Haiyan Jiang, Zhiying Wang, Zhixian Zhong, Yi Zhong   +9 more
wiley   +1 more source

Table_6_Optimized Whole Genome Association Scanning for Discovery of HLA Class I-Restricted Minor Histocompatibility Antigens.xlsx

, 2020
Patients undergoing allogeneic stem cell transplantation as treatment for hematological diseases face the risk of Graft-versus-Host Disease as well as relapse. Graft-versus-Host Disease and the favorable Graft-versus-Leukemia effect are mediated by donor
J. H. Frederik Falkenburg (8558778), Marieke Griffioen (119817), Dyantha I. van der Lee (3115227), Szymon M. Kielbasa (8722956), Margot J. Pont (3115230), M. Willy Honders (8722947), Kyra J. Fuchs (8722944), Ramin Monajemi (6874238), Edith D. van der Meijden (8722950), Alwin E. Adriaans (8722953), Cornelis A. M. van Bergen (5657533), Peter A. C. ’t Hoen (8722959)   +11 more
core   +1 more source

Antigen-specific priming is dispensable in depletion of apoptosis-sensitive T cells for GvHD prophylaxis

Frontiers in Immunology, 2014
Prophylactic approaches to graft versus host disease (GvHD) have employed both phenotypic reduction of T cells and selective elimination of host-primed donor T cells in vitro and in vivo.
Shai eYarkoni, Jerry eStein, Isaac eYaniv, Nadir eAskenasy   +3 more
doaj   +1 more source

Identification of mimotopes for the H4 minor histocompatibility antigen [PDF]

International Immunology, 1998
The H4 minor histocompatibility antigen (HA) of mice includes a single immunogenic peptide presented by H-2Kb molecules that stimulates skin allograft rejection and is immunodominant in the stimulation of cytolytic T lymphocytes (CTL) specific for multiple minor HA.
Strausbauch, M A, Nevala, W K, Roopenian, D C, Stefanski, H E, Wettstein, P J   +4 more
openaire   +2 more sources

IMMUNOBIOLOGY OF ACUTE GRAFT-VERSUS-HOST DISEASE

Медицинская иммунология, 2016
Transplantation of allogeneic hematopoietic stem cells is the only curative option for a number of diseases of hematopoietic system. It is intended to replace the hematopoietic system of the recipient withthe donor’s.
G. A. Efimov, A. S. Vdovin, A. A. Grigoryev, S. Yu. Filkin, N. A. Bykova, V. G. Savchenko   +5 more
doaj   +1 more source