Results 61 to 70 of about 482,752 (300)

MiR‐210: an important player in the pathogenesis of preeclampsia? [PDF]

Journal of Cellular and Molecular Medicine, 2012
Hypoxia is a common feature in solid neoplastic microenvironment and a well-documented factor attributable to therapeutic failure in clinical oncology. Low oxygen availability also plays a central role in the pathogenesis of major ischaemic disorders, such as acute myocardial infarction, stroke and preeclampsia.
Liu, Changjiang, Zhou, Yaojun, Zhang, Zhigao   +2 more
openaire   +2 more sources

MicroRNA-210-5p Contributes to Cognitive Impairment in Early Vascular Dementia Rat Model Through Targeting Snap25

Frontiers in Molecular Neuroscience, 2018
Vascular dementia (VD) is the most common form of dementia in elderly people. However, little is understood about the role of microRNAs (miRNAs) involved in cognitive impairment in early VD. Here, a VD model induced by chronic cerebral ischemia and fetal
Zhenxing Ren, Junlong Yu, Zimei Wu, Wenwen Si, Xianqian Li, Yuqing Liu, Jianhong Zhou, Rudong Deng, Dongfeng Chen   +8 more
doaj   +1 more source

MicroRNA response to hypoxic stress in soft tissue sarcoma cells: MicroRNA mediated regulation of HIF3α [PDF]

, 2014
Background: Hypoxia is often encountered in solid tumors and known to contribute to aggressive tumor behavior, radiation- and chemotherapy resistance resulting in a poor prognosis for the cancer patient.
Gits, C.M.M. (Caroline), IJcken, W.F.J. (Wilfred) van, Jonkers, M.B.E., Kuijk, P.F. (Patricia) van, Mathijssen, A.H.J. (Ron), Muskens, N. (Nikky), Rijck, J.C.W.M. (Jonneke) de, Sleijfer, S. (Stefan), Verweij, J. (Jaap), Wiemer, E.A.C. (Erik)   +9 more
core   +1 more source

A miR-210-3p regulon that controls the Warburg effect by modulating HIF-1α and p53 activity in triple-negative breast cancer

Cell Death and Disease, 2020
Reprogrammed energy metabolism, especially the Warburg effect (aerobic glycolysis), is an emerging hallmark of cancer. Different from other breast cancer subtypes, triple-negative breast cancer (TNBC) exhibits high metabolic remodeling, increased ...
Ye Du, Na Wei, Ruolin Ma, Shuheng Jiang, D. Song   +4 more
semanticscholar   +1 more source

Radiogenomics in clear cell renal cell carcinoma: correlations between advanced CT imaging (texture analysis) and microRNAs expression [PDF]

, 2019
Purpose: A relevant challenge for the improvement of clear cell renal cell carcinoma management could derive from the identification of novel molecular biomarkers that could greatly improve the diagnosis, prognosis, and treatment choice of these ...
Badia, S., Bellini, D., Carbone, A., Caruso, D., Fazi, F., Laghi, A., Marigliano, C., Miglietta, S., Palleschi, G., Pastore, A. L., Petrozza, V., Rengo, M., Tito, C.   +12 more
core   +1 more source

miR-210 Transferred by Lung Cancer Cell Derived Exosomes May Act as Proangiogenic Factor in Cancer-associated Fibroblasts by Modulating JAK2/STAT3 Pathway.

Clinical science, 2020
It has been generally believed that cancer-associated fibroblasts (CAFs) have the ability to increase the process of tumor angiogenesis. However, the potential mechanisms by which cancer-derived exosomes in lung cancer (LC) remains to be investigated. LC-
Junqiang Fan, Guanxin Xu, Zhi‐Bo Chang, Ling Zhu, Jie Yao   +4 more
semanticscholar   +1 more source

The Role of Hypoxia-Induced miR-210 in Cancer Progression [PDF]

International Journal of Molecular Sciences, 2015
Prolonged hypoxia, the event of insufficient oxygen, is known to upregulate tumor development and growth by promoting the formation of a neoplastic environment. The recent discovery that a subset of cellular microRNAs (miRs) are upregulated during hypoxia, where they function to promote tumor development, highlights the importance of hypoxia-induced ...
Dang, K, Myers, KA
openaire   +3 more sources

Hypoxia-Induced MicroRNA-210 Targets Neurodegenerative Pathways

Non-Coding RNA, 2018
Hypoxia-regulated microRNA-210 (miR-210) is a highly conserved microRNA, known to regulate various processes under hypoxic conditions. Previously we found that miR-210 is also involved in honeybee learning and memory, raising the questions of how neural ...
Michelle E. Watts, Sarah M. Williams, Jess Nithianantharajah, Charles Claudianos   +3 more
doaj   +1 more source

Serum miR-210 Contributes to Tumor Detection, Stage Prediction and Dynamic Surveillance in Patients with Bladder Cancer. [PDF]

PLoS ONE, 2015
MiR-210 is the master hypoxamir that generally exhibits oncogenic properties in most human solid tumors including bladder cancer (BC). However, it remains unknown about the clinical significance of circulating miR-210 levels in BC.
Yongmei Yang, Ailin Qu, Jingkang Liu, Rui Wang, Yingjie Liu, Gang Li, Weili Duan, Qian Fang, Xiumei Jiang, Lili Wang, Guixi Zheng, Lutao Du, Xin Zhang, Chuanxin Wang   +13 more
doaj   +1 more source

Small RNA sequencing reveals metastasis-related microRNAs in lung adenocarcinoma [PDF]

, 2017
The majority of lung cancer deaths are caused by metastatic disease. MicroRNAs (miRNAs) are posttranscriptional regulators of gene expression and miRNA dysregulation can contribute to metastatic progression. Here, small RNA sequencing was used to profile
Daugaard, Iben, Hager, Henrik, Hansen, Lise Lotte, Kjeldsen, Tina E, Kjems, Jørgen, Lamy, Philippe, Venø, Morten T, Yan, Yan   +7 more
core   +2 more sources