Results 111 to 120 of about 5,038 (137)

The oncogenic role of the circ_0003997/miR-370-3p/HMGA2 axis in papillary thyroid cancer

Endocrine
Papillary thyroid cancer (PTC) is the most common endocrine malignancy, demonstrating the most rapid incidence growth among solid tumors in the past decades. Notably, aggressive variants frequently manifest metastatic potential and therapeutic resistance, substantially compromising poor prognosis.
Jing, Ma, Juxiang, Liu, Changhong, Dong, Jun, Wang, Limin, Tian, Jinxing, Quan   +5 more
openaire   +2 more sources

Emerging roles of circUBAP2 targeting miR-370-3p in proliferation, apoptosis, and invasion of papillary thyroid cancer cells

Human Cell, 2021
Circular RNAs (circRNAs) have been documented to be aberrantly expressed in many types of malignancies and involved in cancer progression. However, their role in thyroid cancer (TC) remains largely unknown. Our study aimed to explore the role and mechanism of circUBAP2 in TC.
Hui, Xiong, Jinsong, Yu, Guangwei, Jia, Yang, Su, Jianliang, Zhang, Qiu, Xu, Xiaoxiong, Sun   +6 more
openaire   +2 more sources

CXCL12-regulated miR-370–3p functions as a tumor suppressor gene by targeting HMGA2 in nonfunctional pituitary adenomas

Molecular and Cellular Endocrinology, 2019
Silencing of noncoding genes within the imprinted DLK1-MEG3 locus is exclusive to human nonfunctional pituitary adenomas (NFPAs), but the exact mechanism is still unclear. This study was designed to demonstrate the impact of CXCL12 on the expression of miRNAs within this locus and phenotypic alterations of NFPAs.
Feng Cai, Congxin Dai, Shasha Chen, Qun Wu, Xiaohai Liu, Yuan Hong, Zhen Wang, Li Li, Wei Yan, Renzhi Wang, Jianmin Zhang   +10 more
openaire   +2 more sources

Circ-NMNAT1 Drives Tumor Progression in Bladder Cancer by Modulating the miR-370-3p/ATXN2L Axis

Applied Biochemistry and Biotechnology
The relationship between circular RNAs (circRNAs) and tumor growth and metastasis is increasingly well-established. In this study, we sought to shed light on circ-NMNAT1's potential molecular mechanisms in bladder cancer (BCa). circ-NMNAT1, miR-370-3p, and ATXN2L expression profiles were explored using RT-qPCR and/or Western blot techniques.
ChenHui Zhu, LiJuan Lin, ChangQing Huang, ZhaoGuan Li   +3 more
openaire   +2 more sources

Circ_0070203 Promotes Epithelial-mesenchymal Transition in Ovarian Serous Cystadenocarcinoma through miR-370-3p/TGFβR2 Axis

Recent Patents on Anti-Cancer Drug Discovery
Introduction: Circular RNAs (circRNAs) are important biological molecules associated with the pathogenesis of multiple cancers. Objective: This work aimed to investigate the function and molecular mechanism of circ_0070203 in high-grade serous ovarian cystadenocarcinoma (HGSOC).
Qiong, Tang, Huiting, Wen, Haoyue, Hu, Xiaoli, Chen, Shuxiu, Xu, Li, Fan, Longyang, Liu, Jing, Li   +7 more
openaire   +2 more sources

MiR-370-3p targets TLR4 to regulate LPS-induced acute pneumonia in WI-38 cells

Panminerva Medica, 2022
Xi, Yu, Xuejiao, Qian, Rongfei, Sun, Bo, Yang, Hong, Zheng, Ping, Jiang, Xiaoping, Li   +6 more
openaire   +2 more sources

MiR-690 treatment causes decreased fibrosis and steatosis and restores specific Kupffer cell functions in NASH

Cell Metabolism, 2022
Gautm Bandyopadhyay, Wei Ying, Jerrold Olefsky   +2 more
exaly  

[circ_BACH2 affects the malignant biological behavior of papillary thyroid cancer by regulating miR-370-3p].

Zhonghua zhong liu za zhi [Chinese journal of oncology]
Objective: To investigate the influence of circ_BACH2 on the malignant biological behavior of papillary thyroid cancer and its molecular mechanism. Methods: Cancer tissues and paracancer tissues of 51 patients with papillary thyroid carcinoma from the Fourth Central Hospital of Tianjin between 2017 and 2019 were collected.
P, Sun, Y, Feng, L Z, Zhou, F, Pei, B, Su, X C, Qiao   +5 more
openaire   +1 more source

MIR497HG‐Derived miR‐195 and miR‐497 Mediate Tamoxifen Resistance via PI3K/AKT Signaling in Breast Cancer

Advanced Science, 2023
Yue Yu
exaly  

miR-34a-5p and miR-125b-5p attenuate Aβ-induced neurotoxicity through targeting BACE1

Journal of the Neurological Sciences, 2020
Baiping Wang
exaly