Results 91 to 100 of about 5,620 (185)

circ_0013613 Promotes the recovery of spinal cord injury by regulating mir-370-3p/caspase1 to regulate neuronal pyroptosis

Acta Biochimica Polonica, 2023
Spinal cord injury (SCI) is a common disease of the central nervous system. Circular RNAs (circRNAs) play an essential role in neuron disorders. This study aimed to investigate the role and regulatory mechanism of circ_0013613 in promoting functional recovery of spinal cord injury (SCI). The mRNA and miRNA expressions were calculated by RT-QPCR.
Yong Guo, Li Ma, Zhuo Zhang
openaire   +2 more sources

Myc-mediated circular RNA circMcph1/miR-370-3p/Irak2 axis is a progressive regulator in hepatic fibrosis

Life Sciences, 2023
Treating hepatic fibrosis (HF) is a major challenge worldwide. However, the biological functions and regulatory mechanisms of circular RNAs (circRNAs) remain unclear in HF. The present study aimed to elucidate the novel role of circMcph1 in HF.HF mouse model was established by injecting CCl4 intraperitoneally and validated using hematoxylin and eosin ...
Jin-Jin, Xu, Xin, Chen, Sai, Zhu, Ling-Feng, Jiang, Wen-Xian, Ma, Si-Yu, Chen, Xiao-Ming, Meng, Cheng, Huang, Jun, Li   +8 more
openaire   +2 more sources

Dynamic changes of miRNAs in skeletal muscle development at New Zealand rabbits

BMC Genomics, 2021
Background miRNA is one of the crucial roles in the complex and dynamic network that regulates the development of skeletal muscle. The landscape of skeletal muscle miRNAs from fetus to adult in New Zealand rabbits has not been revealed yet.
Jing Jing, Xichun Jiang, Cuiyun Zhu, Qi Zheng, Qianyun Ji, Huiqun Yin, Jingtong Huang, Yixiao Zhu, Jiao Wang, Shuaiqi Qin, Yinghui Ling   +10 more
doaj   +1 more source

Circ_0006174 Drives Triple Negative Breast Cancer Progression and Immune Escape Through Regulating miR‐3139/PD‐L1 Axis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) is characterized as an aggressive malignancy with limited therapeutic options. The circular RNA circ_0006174 has been implicated in oncogenic processes across various cancers; however, its specific role in the pathogenesis of TNBC remains unclear.
Yong‐Zhe Tang, Li Yang, Ling Wang, Xiao‐Qing Zhang, Jie Wang   +4 more
wiley   +1 more source

Circadian Immunity and Vascular Inflammation in Cardiovascular Disease Chronotherapy Windows: Time for a Re‐Assessment

Med Research, EarlyView.
ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang, Ge Zhang, Tian‐Ding Liu, Tianshu Gu, Fengyi Yu, Pengyuan Xu, Wunan Mi, Xuanjiang Zhao, Qian Guo, Honglin Zheng, Taiqi Zhao, Qiang Li, Di Lu, Mingxuan Duan, Chaoyang Yu, Ruhao Wu, Shiqian Zhang, Haonan Zhang, Zeyu Wang, Youyang Zheng, Yan Xiao, Zenglei Zhang, Ge Zhang   +22 more
wiley   +1 more source

Potassium binders and continuation of renin–angiotensin system inhibitors/mineralocorticoid receptor antagonist in chronic kidney disease and heart failure (the DEMONSTRATE database)

Journal of Internal Medicine, EarlyView.
Abstract Introduction Hyperkalaemia is a serious complication in patients with chronic kidney disease (CKD) and heart failure (HF), often leading to the discontinuation of renin–angiotensin–aldosterone system inhibitors (RAASi; renin‐angiotensin system inhibitors [RASi] and mineralocorticoid receptor antagonists [MRAs]) despite their cardiorenal ...
Hans Furuland, Anders Olof Larsson, Milica Uhde, Kristel Parv, Matilda Almstedt, Thomas Cars, Maria K. Svensson   +6 more
wiley   +1 more source

LINC01232 Sponges Multiple miRNAs and Its Clinical Significance in Pancreatic Adenocarcinoma Diagnosis and Prognosis

Technology in Cancer Research & Treatment, 2021
Background: Long noncoding RNAs have been demonstrated to play important roles in different kinds of human malignancy. The purpose of this study was to evaluate the diagnostic and prognostic value of long intergenic non-protein coding RNA 1232 (LINC01232)
Wenyan Du MM, Chengbin Lei MM, Yanzhen Wang MM, Yiwen Ding MM, Peng Tian MM   +4 more
doaj   +1 more source

Obesity, microRNA circulating microRNA signatures reveal core and reversible dysregulations in obesity via machine learning

The Journal of Physiology, EarlyView.
Abstract figure legend Machine learning analysis of circulating microRNA (miRNA) profiles identified a minimal set of biomarkers that distinguish individuals with obesity from lean individuals both before and after weight‐loss intervention. Comparative analyses revealed heterogeneous molecular responses to weight reduction, with some miRNAs showing ...
Yuan Yue, Rajesh Katare, Jeremiah Deng, Daniel Alencar Da Costa, Patrick Manning   +4 more
wiley   +1 more source

LINC00857 contributes to proliferation and lymphomagenesis by regulating miR-370-3p/CBX3 axis in diffuse large B-cell lymphoma [PDF]

, 2021
Yan Huang, Yuanyuan Lin, Xiangxiang Song, Depei Wu   +3 more
openalex   +1 more source

MicroRNA expression in ovarian carcinoma and its correlation with clinicopathological features

World Journal of Surgical Oncology, 2012
Background MicroRNA (miRNA) expression is known to be deregulated in ovarian carcinomas. However, limited data is available about the miRNA expression pattern for the benign or borderline ovarian tumors as well as differential miRNA expression pattern ...
Lee Heejeong, Park Chul, Deftereos Georgios, Morihara Janice, Stern Joshua E, Hawes Stephen E, Swisher Elizabeth, Kiviat Nancy B, Feng Qinghua   +8 more
doaj   +1 more source