Investigating the role of Hedgehog/GLI1 signaling in glioblastoma cell response to temozolomide. [PDF]
, 2018 Resistance to chemotherapy substantially hinders successful glioblastoma (GBM) treatment, contributing to an almost 100% mortality rate. Resistance to the frontline chemotherapy, temozolomide (TMZ), arises from numerous signaling pathways that are ...
Day, Emily S +5 more
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Up-regulation of miR-370-3p restores glioblastoma multiforme sensitivity to temozolomide by influencing MGMT expression [PDF]
Scientific Reports, 2016 AbstractMicroRNAs (miRNA) are believed to play an important role in glioblastoma multiforme (GBM)chemotherapy. Our study aims to investigate potential miRNA biomarkers in GBM. Sixty GBM patients, which were given temozolomide (TMZ) chemotherapy and recurrent radiotherapy, were recruited.
Yong-tao Gao +2 more
openaire +2 more sources
A Regulatory Circuitry Between Gria2, miR-409, and miR-495 Is Affected by ALS FUS Mutation in ESC-Derived Motor Neurons [PDF]
, 2018 Mutations in fused in sarcoma (FUS) cause amyotrophic lateral sclerosis (ALS). FUS is a multifunctional protein involved in the biogenesis and activity of several types of RNAs, and its role in the pathogenesis of ALS may involve both direct effects of
Biscarini, Silvia +10 more
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Global miRNA expression profiling of domestic cat livers following acute Toxoplasma gondii infection [PDF]
, 2017 Although microRNAs (miRNAs) play an important role in liver homeostasis, the extent to which they can be altered by Toxoplasma gondii infection is unknown. Here, we utilized small RNA sequencing and bioinformatic analyses to characterize miRNA expression
Abramo +62 more
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De novo transcriptome sequencing and analysis of the juvenile and adult stages of Fasciola gigantica [PDF]
, 2017 Fasciola gigantica is regarded as the major liver fluke causing fasciolosis in livestock in tropical countries. Despite the significant economic and public health impacts of F.
Cong, Wei +7 more
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The lncRNAs at X Chromosome Inactivation Center: Not Just a Matter of Sex Dosage Compensation [PDF]
, 2022 Non‐coding RNAs (ncRNAs) constitute the majority of the transcriptome, as the result of pervasive transcription of the mammalian genome. Different RNA species, such as lncRNAs, miRNAs, circRNA, mRNAs, engage in regulatory networks based on their ...
Di Palo A. +3 more
core +1 more source
A Human iPSC-derived 3D platform using primary brain cancer cells to study drug development and personalized medicine [PDF]
, 2019 A high throughput histology (microTMA) platform was applied for testing drugs against tumors in a novel 3D heterotypic glioblastoma brain sphere (gBS) model consisting of glioblastoma tumor cells, iPSC-derived neurons, glial cells and astrocytes grown in
Ball, Graeme +7 more
core +4 more sources
Stem Cell Research & Therapy, 2019 Background Human bone marrow-derived mesenchymal stem cells (HBMSCs) are characterized by multiple differentiation potential and potent self-renewal ability, yet much remains to be elucidated on what determines these properties. Long-chain noncoding RNAs
Bo Jia +5 more
doaj +1 more source
Molecular Therapy: Nucleic Acids, 2020 To identify potential therapeutic targets for pulmonary fibrosis induced by silica, we studied the effects of this disease on the expression of microRNAs (miRNAs) in the lung.
Xuemin Gao +12 more
doaj +1 more source
CircASPH Promotes Hepatocellular Carcinoma Progression Through Methylation and Expression of HAO2
Frontiers in Oncology, 2022 CircRNAs have been reported to be related to hepatocellular carcinoma (HCC) development. Limited studies have revealed the expression profile of circRNAs in tumor and para-tumor normal samples in HCC patients.
Han Zhuo +11 more
doaj +1 more source