Results 81 to 90 of about 5,038 (137)

Circ_0020887 Silencing Combats Hypoxic-Induced Cardiomyocyte Injury in an MiR-370-3p/CYP1B1-Dependent Manner

International Heart Journal
Targeting circular RNA has been a novel approach to preventing and limiting acute myocardial infarction (AMI). Here, we planned to investigate the role and mechanism of circ_0020887 in AMI progression.Hypoxic injury in human cardiomyocytes (AC16) was measured using cell counting kit-8 assay, 5-ethynyl-2'-deoxyuridine assay, flow cytometry, and ...
Chen, Huiqin, Cheng, Zhendong, Wang, Meiai, Huang, Qian, Zheng, Dandan, Huang, Qiuhong, Cai, Kefeng   +6 more
openaire   +2 more sources

Temozolomide resistance in glioblastoma: a non-coding RNA viewpoint

Advances in Cancer Biology - Metastasis
As an imidazotetrazine derived from the alkylating substance dacarbazine, Temozolomide (TMZ) is commonly used as the routine chemotherapy for new cases of glioblastoma multiforme (GBM). It substantially improves the clinical outcome of patients.
Maryam Motallebinezhad, Ali Faravash, Mohammad Ghasemian, Zahra Tajik, Mohsen Ahmadi, Solat Eslami, Soudeh Ghafouri-Fard   +6 more
doaj   +1 more source

Circular RNA circ_0003204 inhibits proliferation, migration and tube formation of endothelial cell in atherosclerosis via miR-370-3p/TGFβR2/phosph-SMAD3 axis

Journal of Biomedical Science, 2020
Background Circular RNAs (circRNAs) represent a class of non-coding RNAs (ncRNAs) which are widely expressed in mammals and tissue-specific, of which some could act as critical regulators in the atherogenesis of cerebrovascular disease.
Shanchao Zhang, Guixiang Song, Jing Yuan, Shan Qiao, Shan Xu, Zhihua Si, Yang Yang, Xuxu Xu, Aihua Wang   +8 more
doaj   +1 more source

Urine transcriptomic profile in terms of malignant ovarian tumors

Южно-Российский онкологический журнал
Purpose of the study. Bioinformatic search for transcriptomic markers (based on metabolomic data) and their validation in the urine of serous ovarian adenocarcinoma patients.Materials and methods.
D. S. Kutilin, F. E. Filippov, N. V. Porhanova, A. Yu. Maksimov   +3 more
doaj   +1 more source

Upregulation of circ_0076684 in osteosarcoma facilitates malignant processes by mediating miRNAs/CUX1

Journal of Orthopaedic Surgery and Research
Circular RNAs (circRNAs) are a newly appreciated type of endogenous noncoding RNAs that play vital roles in the development of various human cancers, including osteosarcoma (OS).
Pengfei Cai, Xin Fu, Xiaofei Li, Wei Zhao   +3 more
doaj   +1 more source

In-silico pharmacological insights into the therapeutic potential of microRNAs for microplastic-associated cancers

Frontiers in Cell and Developmental Biology
Microplastics (MPs) are increasingly implicated in cancer biology through effects on gene expression, stress responses, and treatment susceptibility; however, causal links remain provisional.
Akmaral Baspakova, Afshin Zare, Nadiar M. Mussin, Nader Tanideh, Nader Tanideh, Kulyash R. Zhilisbayeva, Ramazon Safarzoda Sharoffidin, Roza Suleimenova, Gulden Yelgondina, Akmeiir E. Kaliyeva, Aigerim A. Umbetova, Ainur Zinaliyeva, Amin Tamadon, Amin Tamadon   +13 more
doaj   +1 more source

Exosomal miR-370-3p increases the permeability of blood-brain barrier in ischemia/reperfusion stroke of brain by targeting MPK1. [PDF]

Aging (Albany NY), 2023
Gu C, Mo W, Wang K, Gao M, Chen J, Zhang F, Shen J.   +6 more
europepmc   +1 more source

Profiling miRNA changes in Epstein-Barr virus lytic infection identifies a function for BZLF1 in upregulating miRNAs from the DLK1-DIO3 locus.

PLoS Pathogens
Cellular and viral miRNAs are thought to play important roles in regulating Epstein-Barr virus (EBV) latent and lytic infections, however, to date, most studies have focussed on latent infections in B cells.
Ashley M Campbell, Victoria C Taylor, Beata Cohan, Lori Frappier   +3 more
doaj   +1 more source

Circular RNA hsa_circ_0004689 (circSWT1) promotes NSCLC progression via the miR-370-3p/SNAIL axis by inducing cell epithelial-mesenchymal transition (EMT). [PDF]

Cancer Med, 2023
Long X, Wang DG, Wu ZB, Liao ZM, Xu JJ.
europepmc   +1 more source

MicroRNAs as potential diagnostic biomarkers for bipolar disorder

Neural Regeneration Research
Abnormal expression of microRNAs is connected to brain development and disease and could provide novel biomarkers for the diagnosis and prognosis of bipolar disorder.
Bridget Martinez, Philip V. Peplow
doaj   +1 more source