Results 31 to 40 of about 45,933 (126)

Effects of chikusetsu saponin Ⅳa on high glucose-induced human renal tubular epithelial cell injury through regulating circEIF4G2/miR-379-5p

Linchuang shenzangbing zazhi, 2022
ObjectiveTo explore the effect of chikusetsu saponin Ⅳa （CHS） on high glucose-induced human renal tubular epithelial cells （HK-2） injury and examine whether or not its mechanism is correlated with the regulation of circEIF4G2 and miR-379-5p expression ...
Qin Li, Chen Bao-guang, Guo Feng-nian, Zhang Qiu-ju   +3 more
doaj   +1 more source

Polyethylenimine-Mediated Delivery of miR-379-5p Suppresses MTDH and FOXP2 in Colorectal Cancer Cells

Gazi Medical Journal
Objective: To develop an optimized polyethylenimine (PEI)-based nanocarrier for the intracellular delivery of miR-379-5p and to evaluate its efficacy in suppressing the oncogenic targets metadherin (MTDH) and Forkhead box P2 (FOXP2) in KRAS-wild-type ...
Ekin Çelik, Ertan Kanbur, Cem Bayram, Çağrı Aydoğan, Miraç Berkay Köksal, Selahattin Ata Aydın, Yiğit Emre Kurt   +6 more
doaj   +2 more sources

The miR-15b-5p/miR-379-3p-FOXO axis regulates cell cycle and apoptosis in scleral remodeling during experimental myopia

Journal of Translational Medicine
Background Myopia is one of the most common eye diseases in children and adolescents worldwide, and scleral remodeling plays a role in myopia progression.
Ruixue Zhang, Ying Wen, Jinpeng Liu, Jiawen Hao, Yuan Peng, Miao Zhang, Yunxiao Xie, Zhaohui Yang, Xuewei Yin, Yongwei Shi, Hongsheng Bi, Dadong Guo   +11 more
doaj   +2 more sources

Abstract 1449 miR-379-5p affects breast cell behavior through its mRNA target UBE2E3

Journal of Biological Chemistry
Lina Yoo, Araya Schroder, Conor Loy, Fernanda Aiala   +3 more
openaire   +2 more sources

A Concise Review on Dysregulation of LINC00665 in Cancers

Cells, 2022
Long Intergenic Non-Protein Coding RNA 665 (LINC00665) is an RNA gene located on the minus strand of chromosome 19. This lncRNA acts as a competing endogenous RNA for miR-4458, miR-379-5p, miR-551b-5p, miR-3619-5p, miR-424-5p, miR-9-5p, miR-214-3p, miR ...
Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Aria Baniahmad, Mohammad Taheri, Mohammadreza Hajiesmaeili   +5 more
doaj   +1 more source

Transcriptome reveals key microRNAs involved in fat deposition between different tail sheep breeds

PLoS ONE, 2022
MicroRNA (miRNA) is a kind of noncoding RNA whose function involved in various biological processes in neuronal maturation and adipocyte cells, such as differentiation, proliferation, development, apoptosis, and metabolism.
Xiaojuan Fei, Meilin Jin, Yuqin Wang, Taotao Li, Zengkui Lu, Zehu Yuan, Huihua Wang, Jian Lu, Kai Quan, Ran Di, Caihong Wei   +10 more
doaj   +2 more sources

Integrated Analysis of lncRNA–miRNA–mRNA Regulatory Network in Rapamycin-Induced Cardioprotection against Ischemia/Reperfusion Injury in Diabetic Rabbits

Cells, 2023
The inhibition of mammalian target of rapamycin (mTOR) with rapamycin (RAPA) provides protection against myocardial ischemia/reperfusion (I/R) injury in diabetes.
Arun Samidurai, Amy L. Olex, Ramzi Ockaili, Donatas Kraskauskas, Sean K. Roh, Rakesh C. Kukreja, Anindita Das   +6 more
doaj   +1 more source

Circulating Exosomal miRNAs as Novel Biomarkers Perform Superior Diagnostic Efficiency Compared With Plasma miRNAs for Large-Artery Atherosclerosis Stroke

Frontiers in Pharmacology, 2021
Recently, exosomal miRNAs have been reported to be associated with some diseases, and these miRNAs can be used for diagnosis and treatment. However, diagnostic biomarkers of exosomal miRNAs for ischemic stroke have rarely been studied.
Mengying Niu, Hong Li, Xu Li, Xiaoqian Yan, Aijun Ma, Xudong Pan, Xudong Pan, Xiaoyan Zhu   +7 more
doaj   +1 more source

RNA Regulatory Networks: Key Hubs in the Panorama of Cancer and Emerging Therapeutic Targets. [PDF]

MedComm (2020)
RNA regulatory networks play a crucial role in the initiation and progression of cancer through various modes of RNA interactions. Notably, circulating RNAs have emerged as potential biomarkers, while targeted interventions in RNA regulatory networks facilitate precise therapeutic strategies. ABSTRACT Cancer is a global health challenge. The initiation
Yin X, Du Z, Jiang S, Liao Y, Wang C, Li J, Zhang H, Wei TT, Zhang W, Zou Z.   +9 more
europepmc   +2 more sources

Epigenetics in B-CLL. [PDF]

Int J Genomics
B‐cell chronic lymphocytic leukemia (B‐CLL) is the most common hematological malignancy in adults. Its clinical course is heterogeneous, ranging from indolent forms with slow progression to aggressive variants refractory to conventional treatment.
Chu A, Soto F, Hurtado R, Tirado CA.
europepmc   +2 more sources