Results 41 to 50 of about 3,800 (160)

miR-379 links glucocorticoid treatment with mitochondrial response in Duchenne muscular dystrophy [PDF]

, 2020
Duchenne Muscular Dystrophy (DMD) is a lethal muscle disorder, caused by mutations in the DMD gene and affects approximately 1:5000-6000 male births. In this report, we identified dysregulation of members of the Dlk1-Dio3 miRNA cluster in muscle biopsies
Amor, F, Barthélémy, I, Bigot, A, Blot, S, Bourg, N, Bénit, P, Corre, G, Israeli, D, Massourides, E, Pinset, C, Richard, I, Rustin, P, Sanson, M, Servais, L, Suel, L, Voit, T, Vu Hong, A   +16 more
core   +4 more sources

Pro-fibrotic and apoptotic activities of circARAP1 in myocardial ischemia–reperfusion injury

European Journal of Medical Research, 2023
Reperfusion modality can cause damage to cardiomyocytes, known as myocardial ischemia–reperfusion injury (MI/RI). Circular RNAs (circRNAs) are fundamental regulators associated with many cardiac diseases, including MI/RI. However, their functional impact
Xi Li, Lei Guo, Jingjing Wang, Xing Yang
doaj   +1 more source

Molecular Signature of Aluminum Hydroxide Adjuvant in Ovine PBMCs by Integrated mRNA and microRNA Transcriptome Sequencing [PDF]

, 2018
There have been few in vivo studies on the effect of aluminum hydroxide adjuvant and its influence on the immune response to vaccination. In this study, lambs received a parallel subcutaneous treatment with either commercial vaccines containing aluminum ...
Abendaño Carbajo, Naiara, Asín, Javier, De Andrés, Damián, Jugo Orrantia, Begoña Marina, Luján, Lluís, Pérez, Marta Maria, Reina, Ramsés, Sistiaga Poveda, Maialen, Varela Martínez, Endika   +8 more
core   +8 more sources

Altered microRNA profile during fracture healing in rats with diabetes

Journal of Orthopaedic Surgery and Research, 2020
Background MicroRNAs (miRNAs) are a class of small non-coding RNA molecules that regulate gene expression. There is increasing evidence that some miRNAs are involved in the pathology of diabetes mellitus (DM) and its complications.
Shunsuke Takahara, Sang Yang Lee, Takashi Iwakura, Keisuke Oe, Tomoaki Fukui, Etsuko Okumachi, Michio Arakura, Yoshitada Sakai, Tomoyuki Matsumoto, Takehiko Matsushita, Ryosuke Kuroda, Takahiro Niikura   +11 more
doaj   +1 more source

microRNAs profiling of small extracellular vesicles from midbrain tissue of Parkinson’s disease

Frontiers in Molecular Neuroscience, 2023
Small extracellular vesicles (sEVs) are generated by all types of cells during physiological or pathological conditions. There is growing interest in tissue-derived small extracellular vesicles (tdsEVs) because they can be isolated from a single tissue ...
Zhengzhe Li, Zhengzhe Li, Dongdong Chen, Dongdong Chen, Renjie Pan, Renjie Pan, Yanbiao Zhong, Tianyu Zhong, Tianyu Zhong, Tianyu Zhong, Zhigang Jiao, Zhigang Jiao, Zhigang Jiao   +12 more
doaj   +1 more source

Gene expression and microrna expression analysis in small arteries of spontaneously hypertensive rats. Evidence for er stress [PDF]

, 2015
Small arteries are known to develop functional and structural alterations in hypertension. However, the mechanisms of this remodeling are not fully understood.We hypothesized that altered gene expression is associated with the development of ...
Arribas, Silvia M., Bakker, Erik N T P, De Vos, Judith, Groma, Gergely, Jongejan, Aldo, Moerland, Perry D., Palao, Teresa, Swärd, Karl, Van Bavel, Ed, Van Weert, Angela   +9 more
core   +5 more sources

Evaluating the expression of miRNAs in the culture medium of human embryos with normal sex chromosomes and embryos with an X sex chromosome (Turner syndrome) [PDF]

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām, 2023
Introduction: Assisted reproductive techniques and Preimplantation Genetic Test (PGT) are performed to detect aneuploidy to achieve a euploid baby's birth in infertile or low-fertility couples.
Shahrzad Aghajani, Ali Salehzadeh, Fatemeh Ghasemian, Marzieh Mehrafza   +3 more
doaj  

Advances in Tumor-Derived Exosomal Non-Coding RNAs Regulating M2 Macrophage Polarization: Molecular Mechanisms and Signaling Pathway. [PDF]

Cancer Med
ABSTRACT Background Cancer persists as a leading cause of global mortality, largely due to the immunosuppressive tumor microenvironment (TME) that facilitates tumor progression and therapy resistance. M2 macrophages dominate this immunosuppressive landscape, and emerging evidence highlights tumor‐derived exosomes (TEXs) as critical mediators of ...
Bian Y, Li J, Cao J, Wang S, Ma C.
europepmc   +2 more sources

Altered microRNA and target gene expression related to Tetralogy of Fallot [PDF]

, 2019
MicroRNAs (miRNAs) play an important role in guiding development and maintaining function of the human heart. Dysregulation of miRNAs has been linked to various congenital heart diseases including Tetralogy of Fallot (TOF), which represents the most ...
Appelt, Sandra, Berger, Felix, Dunkel, Ilona, Grunert, Marcel, Sperling, Silke R.   +4 more
core   +2 more sources

Exploring a role for regulatory miRNAs in wound healing during ageing: involvement of miR-200c in wound repair [PDF]

, 2017
YesMultiple factors and conditions can lead to impaired wound healing. Chronic non-healing wounds are a common problem among the elderly. To identify microRNAs negatively impacting the wound repair, global miRNA profiling of wounds collected from young
Ahmed, Mohammed I., Aunin, Eerik, Botchkareva, Natalia V., Broadley, David, Mardaryev, Andrei N.   +4 more
core   +1 more source