Results 61 to 70 of about 3,800 (160)

Diagnostic and prognostic potential of eight whole blood microRNAs for equine sarcoid disease.

PLoS ONE, 2021
MicroRNAs have been proposed as biomarkers for equine sarcoids, the most prevalent equine skin tumors globally. This study served to validate the diagnostic and prognostic potential of whole blood microRNAs identified in a previous study for long-term ...
Jeanne Cosandey, Eman Hamza, Vinzenz Gerber, Alessandra Ramseyer, Tosso Leeb, Vidhya Jagannathan, Klaudia Blaszczyk, Lucia Unger   +7 more
doaj   +1 more source

Cholesterol metabolism is a potential therapeutic target in Duchenne muscular dystrophy [PDF]

, 2021
Background: Duchenne muscular dystrophy (DMD) is a lethal muscle disease detected in approximately 1:5000 male births. DMD is caused by mutations in the DMD gene, encoding a critical protein that links the cytoskeleton and the extracellular matrix in ...
Amor, F, Blaie, S, Corre, G, Israeli, D, Richard, I, Sanson, M, Servais, L, Suel, L, Voit, T, Vu Hong, A   +9 more
core  

Gut Microbiota‐Non‐Coding RNA Axis in Immune Modulation and Disease: From Mechanisms to Clinical Translation

Advanced Science, EarlyView.
ABSTRACT Immune homeostasis is indispensable for preserving organismal integrity, orchestrated through complex molecular networks encompassing immune cell dynamics, microbial cues, and epigenetic regulation. Among these, the gut microbiota‐non‐coding RNA (ncRNA) axis has recently garnered substantial attention as a multifaceted modulator of host ...
Bonan Chen, Guoming Chen, Xieyuan Leng, Qianfan Li, Wenhao Wu, Wenqiu Wu, Zixuan Liu, Zilan Zhong, Xiaohong Zheng, Wei Kang, Fazheng Ren, Yigan Zhang, Juan Chen   +12 more
wiley   +1 more source

MicroRNA-379-5p/YBX1 Axis Regulates Cellular EMT to Suppress Migration and Invasion of Nasopharyngeal Carcinoma Cells

Cancer Management and Research, 2020
Fei Zhang,1 Chuanxin Duan,1 Shucheng Yin,2 Ying Tian1 1Department of Otolaryngology, Maternal and Child Health Care Hospital of Hubei Province and Women and Children’s Hospital of Hubei Province, Wuhan 430070, People’s Republic of China ...
Zhang F, Duan C, Yin S, Tian Y
doaj  

Salivary miR-21 is a potential biomarker for canine mast cell tumors [PDF]

, 2022
MicroRNAs (miRNAs) are a class of noncoding RNA molecules playing a crucial role in tumor modulation targeting mRNA. This study aimed to validate the diagnostic potential of a panel of 3 miRNAs previously identified in canine mast cell tumors (MCTs), miR-
Cristina Lecchi, Damiano Stefanello, Emanuela DallaCosta, Fabrizio Ceciliani, Lavinia E. Chiti, Roberta Ferrari, Valentina Zamarian, Valeria Grieco   +7 more
core   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Reduced levels of methyltransferase DNMT2 sensitize human fibroblasts to oxidative stress and DNA damage that is accompanied by changes in proliferation-related miRNA expression

Redox Biology, 2018
Methyltransferase DNMT2 is suggested to be involved in the regulation of numerous processes, however its biological significance and underlying molecular mechanisms remain elusive.
Anna Lewinska, Jagoda Adamczyk-Grochala, Ewa Kwasniewicz, Anna Deregowska, Ewelina Semik, Tomasz Zabek, Maciej Wnuk   +6 more
doaj   +1 more source

Establishment of Repertoire of Placentome-Associated MicroRNAs and Their Appearance in Blood Plasma Could Identify Early Establishment of Pregnancy in Buffalo (Bubalus bubalis)

Frontiers in Cell and Developmental Biology, 2021
Precise early pregnancy diagnosis in dairy animals is of utmost importance for an efficient dairy production system. Not detecting a dairy animal pregnant sufficiently early after the breeding results to extending the unproductive time of their milk ...
Parul Sarwalia, Mustafa Raza, Apoorva Soni, Pratiksha Dubey, Pratiksha Dubey, Rajeev Chandel, Rakesh Kumar, A. Kumaresan, Suneel Kumar Onteru, Ankit Pal, Kalpana Singh, Mir Asif Iquebal, Sarika Jaiswal, Dinesh Kumar, T. K. Datta   +14 more
doaj   +1 more source

Advanced extracellular vesicle immunotherapy

FlexMat, EarlyView.
A diagrammatic depiction of the therapeutic applicability of extracellular vesicles (EVs) in immunotherapy. This review explores the dual roles of tumor‐derived and immune cell‐derived EVs in cancer immunotherapy, discusses recent progress in EV engineering that improve their clinical utility, and evaluates their potential to augment existing ...
Jingjing Zhang, Yunfei Mu, Xianyue Ji, Xiaoting Jiang, Ruiheng Wang, Xianguang Ding, Lianhui Wang   +6 more
wiley   +1 more source

Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto, Samaneh Ghadami, Kristen Dellinger   +2 more
wiley   +1 more source