Results 71 to 80 of about 3,800 (160)

MOV10 binding circ-DICER1 regulates the angiogenesis of glioma via miR-103a-3p/miR-382-5p mediated ZIC4 expression change

Journal of Experimental & Clinical Cancer Research, 2019
Background RNA binding proteins (RBPs) have been reported to interact with RNAs to regulate gene expression. Circular RNAs (circRNAs) are a type of endogenous non-coding RNAs, which involved in the angiogenesis of tumor.
Qianru He, Lini Zhao, Xiaobai Liu, Jian Zheng, Yunhui Liu, Libo Liu, Jun Ma, Heng Cai, Zhen Li, Yixue Xue   +9 more
doaj   +1 more source

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, Volume 46, Issue 2, Page 475-512, March 2026.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

Transcriptome reveals key microRNAs involved in fat deposition between different tail sheep breeds

PLoS ONE, 2022
MicroRNA (miRNA) is a kind of noncoding RNA whose function involved in various biological processes in neuronal maturation and adipocyte cells, such as differentiation, proliferation, development, apoptosis, and metabolism.
Xiaojuan Fei, Meilin Jin, Yuqin Wang, Taotao Li, Zengkui Lu, Zehu Yuan, Huihua Wang, Jian Lu, Kai Quan, Ran Di, Caihong Wei   +10 more
doaj  

EVALUATION OF THE PLASMA MICRO RNA EXPRESSION LEVELS IN SECONDARY HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS

Mediterranean Journal of Hematology and Infectious Diseases, 2013
Background: Hemophagocytic lymphohistiocytosis (HLH) is a life threatening hyper inflammatory disease. Micro RNAs (miRNA) are about 22 nucleotide-long, small RNAs encoded with genes, and they have regulatory functions in immune response.
Ali Bay, Enes Coskun, serdar oztuzcu, sercan ergun, fatih yilmaz, elif aktekin   +5 more
doaj   +1 more source

Changes in expression of miRNAs from the DLK1-DIO3 locus are characteristic of relapsing-remitting multiple sclerosis regardless of the disease activity

Неврология, нейропсихиатрия, психосоматика, 2022
The role of miRNAs – small, regulatory, noncoding RNAs – in the multiple sclerosis (MS) development is being intensively investigated. Previously, we the first who observed a significant increase in the expression of 26 microRNA genes localized in the ...
N. M. Baulina, A. R. Kabaeva, A. N. Boyko, O. O. Favorova   +3 more
doaj   +1 more source

Combining laser microdissection and microRNA expression profiling to unmask microRNA signatures in complex tissues [PDF]

, 2019
Neglecting tissue heterogeneity during the analysis of microRNA (miRNA) levels results in average signals from an unknown mixture of different cell types that are difficult to interpret.
Hackl, Matthias, Kuiper, Timara, Molema, Grietje, Schraml, Elisabeth, Skalicky, Susanna, Zwiers, Peter J.   +5 more
core   +1 more source

Tumor‐Associated Macrophages as Therapeutic Targets: Deciphering Interaction Networks and Advancing Clinical Translation

MedComm, Volume 7, Issue 2, February 2026.
Tumor‐associated macrophages are the most abundant immune cells in the tumor microenvironment, driving malignant progression and treatment resistance. This review summarizes the protumor mechanisms of TAMs (including phagocytosis modulation, metabolic reprogramming, exosomal communication, and immune interactions), evaluates three major strategies ...
Wurihan Bao, Xiaojie Qu, Yiqi Wang, Dan Huang, Huiling Zhang, Mingyuan Dong, Han Sun, Zhaogang Yang, Xuefeng Li   +8 more
wiley   +1 more source

Circulating microRNAs in patients with hormone receptor-positive, metastatic breast cancer treated with dovitinib

Clinical and Translational Medicine, 2017
Background Serial analysis of biomarkers in the circulation of patients undergoing treatment (“liquid biopsies”) can provide new insights into drug effects.
Narayan Shivapurkar, Eveline E. Vietsch, Erin Carney, Claudine Isaacs, Anton Wellstein   +4 more
doaj   +1 more source

Integrated Hypothalamic Transcriptome Profiling Reveals the Reproductive Roles of mRNAs and miRNAs in Sheep

Frontiers in Genetics, 2020
Early studies have provided a wealth of information on the functions of microRNAs (miRNAs). However, less is known regarding their functions in the hypothalamus involved in sheep reproduction. To explore the potential roles of hypothalamic messenger RNAs
Zhuangbiao Zhang, Jishun Tang, Jishun Tang, Ran Di, Qiuyue Liu, Xiangyu Wang, Shangquan Gan, Xiaosheng Zhang, Jinlong Zhang, Mingxing Chu, Wenping Hu   +10 more
doaj   +1 more source

Differential expression of microRNAs in adipose tissue after long-term high-fat diet-induced obesity in mice. [PDF]

PLoS ONE, 2012
Obesity is a major health concern worldwide which is associated with increased risk of chronic diseases such as metabolic syndrome, cardiovascular disease and cancer.
Dionysios V Chartoumpekis, Apostolos Zaravinos, Panos G Ziros, Ralitsa P Iskrenova, Agathoklis I Psyrogiannis, Venetsana E Kyriazopoulou, Ioannis G Habeos   +6 more
doaj   +1 more source