Results 81 to 90 of about 3,800 (160)

MiR-379-5p improved locomotor function recovery after spinal cord injury in rats by reducing endothelin 1 and inhibiting astrocytes expression.

European review for medical and pharmacological sciences, 2019
The aim of this study was to investigate the effect of microRNA-214-5p (miR-214-5p) on spinal cord injury (SCI) and to explore the mechanism of action in pathophysiological relevance.The model of SCI was successfully established in rats aged 6-8 weeks.
A, J.-C., Li, Z.-Y., Long, Q.-F., Wang, D.-Y., Zhao, H.-S., Jia, S.-L., Zhang, W.-H.   +6 more
openaire   +2 more sources

Additional file 1 of Androgen-induced exosomal miR-379-5p release determines granulosa cell fate: cellular mechanism involved in polycystic ovaries

, 2023
Additional file 1: Supplementary Figure 1. Androgen excess in human PCOS subjects is associated with reduced follicular fluid-derived exosomal mir-379-5p content and granulosa cell proliferation. (A) Follicular fluids from the dominant follicles (≥ 20 mm; n = 25 Non-PCOS and 13 PCOS subjects) of PCOS subjects exhibited significantly higher free ...
Salehi, Reza, Wyse, Brandon A., Asare-Werehene, Meshach, Esfandiarinezhad, Fereshteh, Abedini, Atefeh, Pan, Bo, Urata, Yoko, Gutsol, Alex, Vinas, Jose L., Jahangiri, Sahar, Xue, Kai, Xue, Yunping, Burns, Kevin D., Vanderhyden, Barbara, Li, Julang, Osuga, Yutaka, Burger, Dylan, Tan, Seang-Lin, Librach, Clifford L., Tsang, Benjamin K.   +19 more
openaire   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, Volume 36, Issue 1, 2 January 2026.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Radiofrequency Echographic Multi-Spectrometry for Early Bone Health: The REMS-Bone Study Protocol (Trial Acronym: REMS-Bone) [PDF]

Background: Bone health begins with maternal health and nutrition, which influences skeletal mass and bone mineral density (BMD) already in utero. Maximization of bone mass during skeletal growth has become the goal of primary prevention of osteopenia ...
Papini, Anna Maria
core   +4 more sources

Melanoma: Pathogenesis and Targeted Therapy

MedComm, Volume 7, Issue 1, January 2026.
The treatment landscape for advanced melanoma has evolved significantly. BRAF–MEK inhibitor combinations are standard for BRAF‐mutant melanoma, whereas targeting NRAS mutations is more challenging, with MEK inhibitors like tunlametinib emerging as an option.
Yang Fu, Jie Liu, Zeming Mo, Bin Wang, Yaotiao Deng, Yu Jiang   +5 more
wiley   +1 more source

Comparison of Adult Testis and Ovary MicroRNA Expression Profiles in Reeves’ Pond Turtles (Mauremys reevesii) With Temperature-Dependent Sex Determination

Frontiers in Genetics, 2020
Some differentially expressed genes (DEGs) that encode key enzymes involved in steroidogenic biosynthesis (CYP19A1) and key molecules related to gonadal functions (DMRT1, SOX9, AMH, FOXL2, WNT4, RSPO2, and GDF9) have been identified in adult gonadal RNA ...
Lei Xiong, Lei Xiong, Mengli Yang, Kai Zheng, Ziming Wang, Shengli Gu, Shengli Gu, Jiucui Tong, Jiucui Tong, Jianjun Liu, Nadar Ali Shah, Liuwang Nie   +11 more
doaj   +1 more source

MicroRNA profiling as a novel diagnostic tool for identification of patients with inflammatory and/or virally induced cardiomyopathies

ESC Heart Failure, 2021
Aims MicroRNAs (miRNAs) might be used as prospective biomarkers for the identification of unexplained heart failure caused by a viral and/or inflammatory process.
Ganna Aleshcheva, Heiko Pietsch, Felicitas Escher, Heinz‐Peter Schultheiss   +3 more
doaj   +1 more source

Microvascular Health as a Key Determinant of Organismal Aging

Advanced Science, Volume 12, Issue 47, December 18, 2025.
Abstract Aging is a complex, multifaceted process affecting all organ systems, with vascular aging playing a central role in organismal health decline. Beyond its role in circulation, the vascular system acts as a dynamic interface between tissues, influencing countless physiological functions such as tissue regeneration and repair, immune responses ...
Mattia Cenciarini, Andrea Uccelli, Francesca Mangili, Myriam Grunewald, Simone Bersini   +4 more
wiley   +1 more source

Ovarian Aging: Mechanisms, Age‐Related Disorders, and Therapeutic Interventions

MedComm, Volume 6, Issue 12, December 2025.
A comprehensive overview of the molecular mechanisms underlying ovarian aging, its association with age‐related diseases, and potential therapeutic interventions. Ovarian aging involves DNA damage, mitochondrial dysfunction, oxidative stress, telomere attrition, and follicular depletion, driving age‐related infertility, menopause, and multiple systemic
Xingyu Liu, Yuanqu Zhao, Yanzhi Feng, Shixuan Wang, Jinjin Zhang   +4 more
wiley   +1 more source

Immunosenescence: Molecular Mechanisms, Diseases, and Therapeutic Innovations

MedComm, Volume 6, Issue 12, December 2025.
Along with organismal aging or pathogenic processes especially tumor, multiple immune cell types exhibit those well‐established hallmarks of cellular senescent phenotype, mainly characterized by irreversible cell cycle arrest, metabolic disorder, and over production of SASP.
Ninghan Gong, Xiting Pan, Yusi Deng, Jiajia Che, Junhao Bao, Mengqi Wang, Chuan Xu, Xiaowei Liu, Ying Shi   +8 more
wiley   +1 more source