Results 81 to 90 of about 45,933 (126)

A comprehensive method for identification of suitable reference genes in extracellular vesicles

Journal of Extracellular Vesicles, 2017
Reverse transcription–quantitative polymerase chain reaction (RT-qPCR) is one of the most sensitive, economical and widely used methods for evaluating gene expression.
Kenneth Gouin, Kiel Peck, Travis Antes, Jennifer Leigh Johnson, Chang Li, Sharon Denise Vaturi, Ryan Middleton, Geoff de Couto, Ann-Sophie Walravens, Luis Rodriguez-Borlado, Rachel Ruckdeschel Smith, Linda Marbán, Eduardo Marbán, Ahmed Gamal-Eldin Ibrahim   +13 more
doaj   +1 more source

A-to-I-edited miRNA-379-5p inhibits cancer cell proliferation through CD97-induced apoptosis.

Journal of Clinical Investigation, 2019
Both miRNAs and A-to-I RNA editing, a widespread nucleotide modification mechanism, have recently emerged as key players in cancer pathophysiology. However, the functional impact of RNA editing of miRNAs in cancer remains largely unexplored.
Xiaoyan Xu, Yumeng Wang, K. Mojumdar, Zhicheng Zhou, K. Jeong, L. Mangala, Shuangxing Yu, Y. Tsang, Cristian Rodríguez-Aguayo, Yiling Lu, G. Lopez-Berestein, A. Sood, G. Mills, Han Liang   +13 more
semanticscholar   +1 more source

MicroRNA-379-5p suppresses renal fibrosis by regulating the LIN28/let-7 axis in diabetic nephropathy

International Journal of Molecular Medicine, 2019
MicroRNAs (miRNAs or miRs) play an important role in pathological processes in diabetic nephropathy (DN). This study aimed to explore whether miR-379-5p is associated with renal fibrosis in DN and to elucidate the underlying mechanisms.
Nan Li, Li-Juan Wang, Weilong Xu, Su Liu, Jiang-yi Yu   +4 more
semanticscholar   +1 more source

MicroRNA-379-5p is associated with biochemical premature ovarian insufficiency through PARP1 and XRCC6

Cell Death and Disease, 2018
Premature ovarian insufficiency (POI) imposes great challenges on women’s fertility and lifelong health. POI is highly heterogeneous and encompasses occult, biochemical, and overt stages.
Yujie Dang, Xiaoyan Wang, Yajing Hao, Xinyue Zhang, Shidou Zhao, Jin-long Ma, Yingying Qin, Zi-jiang Chen   +7 more
semanticscholar   +1 more source

Sources of Individual Variability: Mirnas That Predispose to Neuropathic Pain Identified Using Genome-Wide Sequencing

Molecular Pain, 2014
Background: We carried out a genome-wide study, using microRNA sequencing (miRNA-seq), aimed at identifying miRNAs in primary sensory neurons that are associated with neuropathic pain. Such scans usually yield long lists of transcripts regulated by nerve
Kiran Kumar Bali, Michael Hackenberg, Avigail Lubin, Rohini Kuner, Marshall Devor   +4 more
doaj   +1 more source

Role of mast cell-derived exosomes in exacerbating neuronal injury of experimental cerebral malaria

Parasites & Vectors
Background Cerebral malaria (CM), a fatal neurological complication of Plasmodium falciparum infection, is partially driven by neuronal injury. Emerging evidence highlights exosomes as vital mediators of mast cell–neuron interactions in neurological ...
Qianru Wang, Xiumei Mo, Hua Li, Mingqiu Ye, Guojun Fei, Pinru Chen, Yongfei Wang, Xinpeng Hou, Jiajing He, Wenbin Liu, Jie Wang, Hui Yin, Zujun Deng, Xiaobao Jin, Zhenlong Liu, Qi Wang, Bo Huang   +16 more
doaj   +1 more source

Integrative Review of Molecular, Metabolic, and Environmental Factors in Spina Bifida and Congenital Diaphragmatic Hernia: Insights into Mechanisms and Emerging Therapeutics

Cells
Spina Bifida (SB) and Congenital Diaphragmatic Hernia (CDH) are complex congenital anomalies that pose significant challenges in pediatric healthcare. This review synthesizes recent advancements in understanding the genetic, metabolic, and environmental ...
Angelika Buczyńska, Iwona Sidorkiewicz, Przemysław Kosiński, Adam Jacek Krętowski, Monika Zbucka-Krętowska   +4 more
doaj   +1 more source

miR-379-5p regulates the proliferation, cell cycle, and cisplatin resistance of oral squamous cell carcinoma cells by targeting ROR1.

American journal of translational research
To analyze the regulatory mechanism microRNA miR-379-5p in oral squamous cell carcinoma (OSCC).We collected serum samples from patients with OSCC and examined the expression of miR-379-5p and receptor tyrosine kinase-like orphan receptor 1 (ROR1) by real-time polymerase chain reaction and western blot.
Lei, Meng, Yanlin, Du, Banglian, Deng, Yinzhong, Duan   +3 more
openaire   +1 more source

miR-146a/b-5p-IRAK1-NF-κB Axis Regulates Unexplained Recurrent Spontaneous Abortion. [PDF]

J Mol Recognit
He F, Fan S, Chen L, Lou J, Lin Z, Liu Y, Yan T, Zhang Y.   +7 more
europepmc   +1 more source