Results 171 to 180 of about 4,926 (186)

Neuroprotective effects of miR-532-5p against ischemic stroke

Metabolic Brain Disease, 2020
Stroke can cause death and disability and has a high incidence with many complications. So far, effective treatment options for stroke are still limited. MicroRNA-532-5p (miR-532-5p) is significantly downregulated in stroke. However, the role of miR-532-5p in ischemic stroke is still unclear.
Jingwei Mu, Xi Cheng, Shanshan Zhong, Xiaohong Chen, Chuansheng Zhao   +4 more
openaire   +2 more sources

CircCHMP5 Contributes to Ox-LDL-induced Endothelial Cell Injury Through the Regulation of MiR-532-5p/ROCK2 axis

Cardiovascular Drugs and Therapy, 2022
Aberrant expression of circular RNA (circRNA) has been demonstrated to be related to atherosclerosis (AS) formation. However, the mechanism of circCHMP5 (also known as hsa_circ_0003575) in AS formation remains unclear.Oxidized low-density lipoprotein (ox-LDL) was used to treat human umbilical vein endothelial cells (HUVECs) to construct a cell injury ...
Xia Li, Xiaoli Kang, Yali Di, Shuxian Sun, Liming Yang, Bin Wang, Zheng Ji   +6 more
openaire   +2 more sources

MiR-532-5p Suppresses Migration and Invasion of Lung Cancer Cells Through Inhibiting CCR4

Cancer Biotherapy and Radiopharmaceuticals, 2020
Background: Studies showed that miR-532-5p suppresses proliferation and induces apoptosis of lung cancer (LC) cells; its role in LC is not fully understood. Therefore, this research aimed to reveal the effect and mechanism of miR-532-5p on migration and invasion of LC cells.
Jingjing, Hu, Lu, Wang, Caihong, Guan
openaire   +2 more sources

miR-532-5p Inhibits Non-Small Cell Lung Cancer Progression In Vivo and In Vitro by Targeting Yin Yang 1

Critical Reviews in Eukaryotic Gene Expression, 2022
Lung cancer is a common cancer that is familiar to people and has the highest global incidence; among all lung cancer patients, 85% are non-small cell lung cancer (NSCLC). A number of microRNAs (miRNAs), including miR-532-5p, are implicated in the pathophysiological processes of tumorigenesis.
Song, Li, Chunlin, Zhu, Quandong, Wang, Yongsi, Wen   +3 more
openaire   +2 more sources

Exosomal miR-532–5p from bone marrow mesenchymal stem cells reduce intervertebral disc degeneration by targeting RASSF5

Experimental Cell Research, 2020
The transplantation of bone marrow mesenchymal stem cells (BMSCs) has been found to be used as an effective therapy of intervertebral disc degeneration (IDD). However, the underlying mechanisms of BMSCs in the progress of IDD are not fully explained.
Guangduo, Zhu, Xiaowei, Yang, Cheng, Peng, Lei, Yu, Yingjie, Hao   +4 more
openaire   +2 more sources

MiR-532-5p alleviates hypoxia-induced cardiomyocyte apoptosis by targeting PDCD4

Gene, 2018
MicroRNAs (miRNAs) are a class of endogenous non-coding RNAs involved in regulating various biological processes at the post-transcription level. Accumulating evidence suggests that hypoxia caused by acute myocardial infarction induces cardiomyocyte damage including apoptosis.
Jideng, Ma, Jinwei, Zhang, Yujie, Wang, Keren, Long, Xun, Wang, Long, Jin, Qianzi, Tang, Li, Zhu, Guoqing, Tang, Xuewei, Li, Mingzhou, Li   +10 more
openaire   +2 more sources

Circ_0007841 knockdown confers cisplatin sensitivity to ovarian cancer cells by down-regulation of NFIB expression in a miR-532-5p-dependent manner

Journal of Chemotherapy, 2022
Cisplatin (DDP) is first-line management for ovarian cancer (OC). Previous data have suggested that circular RNA_0007841 (circ_0007841) regulates OC progression; however, there is no data on its role in the sensitivity of OC cells to DDP. RNA expression of circ_0007841, microRNA-532-5p (miR-532-5p) and nuclear factor I B (NFIB) was detected by ...
Yuan, Gao, Yan, Huang
openaire   +2 more sources

Long Noncoding RNA Taurine-Upregulated Gene 1 Knockdown Protects Cardiomyocytes Against Hypoxia/Reoxygenation-induced Injury Through Regulating miR-532-5p/Sox8 Axis

Journal of Cardiovascular Pharmacology, 2020
Background: Long noncoding RNA taurine-upregulated gene 1 (TUG1) has been reported to involve in the processing of cardiac ischemia/reperfusion injury after myocardial infarction. Thus, this study further investigates the underlying mechanisms of TUG1 in hypoxia/reoxygenation (H/R)-induced cardiomyocyte injury in vitro.
Xinyong, Cai, Shu, Wang, Lang, Hong, Songping, Yu, Bin, Li, Hong, Zeng, Xu, Yang, Ping, Zhang, Liang, Shao   +8 more
openaire   +2 more sources

A genetic variant located in the miR-532-5p-binding site of TGFBR1 is associated with the colorectal cancer risk

Journal of Gastroenterology, 2018
Genome-wide association studies have identified genes in the transforming growth factor-β (TGFβ) signaling pathway that are responsible for regulating carcinogenesis.We searched for single-nucleotide polymorphisms (SNPs) located within 3'-untranslated regions (3'-UTRs) that might affect the ability of miRNAs to bind genes in the TGFβ pathway for ...
Dongying, Gu, Shuwei, Li, Mulong, Du, Cuiju, Tang, Haiyan, Chu, Na, Tong, Zhengdong, Zhang, Meilin, Wang, Jinfei, Chen   +8 more
openaire   +2 more sources

Bone marrow mesenchymal stem cells‐derived exosomes mediate nuclear receptor coactivator‐3 expression in osteoblasts by delivering miR‐532‐5p to influence osteonecrosis of the femoral head development

Cell Biology International, 2022
AbstractExosomes (Exo) originated from bone marrow mesenchymal stem cells (BMSCs) have therapeutic impacts on osteonecrosis of the femoral head (ONFH), and microRNA (miR)‐532‐5p has been confirmed to participate in ONFH progression. In the research, it was figured out whether BMSCs‐Exo could relieve ONFH by delivering miR‐532‐5p.
XiaoYong Lan, HaiPing Ma, YiPin Xiong, LingFeng Zou, Zhen Yuan, YuHong Xiao   +5 more
openaire   +2 more sources