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Down-regulation of miR-543 expression increases the sensitivity of colorectal cancer cells to 5-Fluorouracil through the PTEN/PI3K/AKT pathway. [PDF]
Biosci Rep, 2019 Liu G, Zhou J, Dong M.
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The role of miR‐543 in human cancerous and noncancerous diseases
Journal of Cellular Physiology, 2020AbstractMicroRNA (miRNA) is a noncoding single‐stranded RNA molecule that can regulate the posttranscriptional expression level of a gene by binding to the 3′‐untranslated region (3′‐UTR) of the target messenger RNA. miR‐543 is a kind of miRNA, which plays an important role in the occurrence and development of various human cancerous and noncancerous ...
Cong Zhou, Xin Zhao, Shiwei Duan
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LncRNA SNHG6 promotes LMO3 expression by sponging miR-543 in glioma
Molecular and Cellular Biochemistry, 2020Small nucleolar RNA host gene 6 (SNHG6) was a newly discovered long non-coding RNA, which was involved in the occurrence and development of a variety of cancers and was on the rise in human cancers. However, the molecular mechanism of SNHG6 in glioma required further investigation.
Yin Zhang, Jiayin An, Yuchun Pei
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MiR-543 functions as tumor suppressor in ovarian cancer by targeting TWIST1.
Journal of biological regulators and homeostatic agents, 2020MicroRNAs (miRNAs) have been demonstrated to have promoting or inhibiting effects on the tumorigenesis of multiple cancers, including ovarian cancer (OC), by regulating its downstream target genes. In the presented experiment, our aim was to explore the role of miR-543 in OC cell proliferation and invasion. Results of quantitative reverse transcription-
Q, Yu +5 more
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miR-543 impairs cell proliferation, migration, and invasion in breast cancer by suppressing VCAN
Biochemical and Biophysical Research Communications, 2021Breast cancer (BC) continues to plague millions of people worldwide. MicroRNAs have been observed to be closely associated with many cancers and may serve as promising biomarkers for the diagnosis of BC. BC tissue samples were collected from 26 patients, and qRT-PCR and western blotting were performed to evaluate the levels of miR-543 and VCAN.
Rong, Li +4 more
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miR-543 inhibites cervical cancer growth and metastasis by targeting TRPM7
Chemico-Biological Interactions, 2019Dysregulation of miR-543 has been implicated to play crucial roles in various human cancers. However, the function of miR-543 involved in cervical cancer (CC) progress remains largely unknown. Thus, this study aimed to explore the potential role of miR-543 and the underlying mechanisms in human CC. In this study, we found that miR-543 was significantly
Xiaoying, Liu, Lu, Gan, Jing, Zhang
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miR-543 promotes gastric cancer cell proliferation by targeting SIRT1
Biochemical and Biophysical Research Communications, 2016SIRT1, a class III histone deacetylase, exerts inhibitory effects on tumorigenesis and is downregulated in gastric cancer. However, the role of microRNAs in the regulation of SIRT1 in gastric cancer is still largely unknown. Here, we identified miR-543 as a predicted upstream regulator of SIRT1 using 3 different bioinformatics databases.
Juan, Li +4 more
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Human Cell, 2019
MicroRNAs (miRNAs) are defined as small, non-coding RNAs that act as post-transcriptional regulators of gene expression. Dysfunction of miRNAs was involved in the initiation and progression of nasopharyngeal carcinoma (NPC). Here, we found that miR-543 was markedly overexpressed in NPC tissues and cell lines.
Xue Jiang, Baoqiang Dai, Lichun Feng
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MicroRNAs (miRNAs) are defined as small, non-coding RNAs that act as post-transcriptional regulators of gene expression. Dysfunction of miRNAs was involved in the initiation and progression of nasopharyngeal carcinoma (NPC). Here, we found that miR-543 was markedly overexpressed in NPC tissues and cell lines.
Xue Jiang, Baoqiang Dai, Lichun Feng
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Down-regulation of the miR-543 alleviates insulin resistance through targeting the SIRT1
Biochemical and Biophysical Research Communications, 2015Insulin resistance plays an important role in the development of hypertension, which is seriously detrimental to human health. Recently, Sirtuin-1 (SIRT1) has been found to participate in regulation of insulin resistance. Therefore, further studies focused on the SIRT1 regulators might provide a potential approach for combating insulin resistance and ...
Xiaojing, Hu +6 more
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