Results 81 to 90 of about 319,034 (267)

Regulation of microRNA during cardiomyocyte maturation in sheep. [PDF]

, 2015
BACKGROUND: There is a limited capacity to repair damage in the mammalian heart after birth, which is primarily due to the inability of cardiomyocytes to proliferate after birth.
Botting, Kimberley J, Brooks, Doug A, McMillen, I Caroline, Morrison, Janna L, Porrello, Enzo R, Tellam, Ross L, Zhang, Song   +6 more
core   +2 more sources

MicroRNA Profiling in the Medial and Lateral Habenula of Rats Exposed to the Learned Helplessness Paradigm: Candidate Biomarkers for Susceptibility and Resilience to Inescapable Shock. [PDF]

PLoS ONE, 2016
Depression is a highly heterogeneous disorder presumably caused by a combination of several factors ultimately causing the pathological condition. The genetic liability model of depression is likely to be of polygenic heterogeneity.
Katrine Svenningsen, Morten T Venø, Kim Henningsen, Anne S Mallien, Line Jensen, Trine Christensen, Jørgen Kjems, Barbara Vollmayr, Ove Wiborg   +8 more
doaj   +1 more source

A plasma 3-marker microRNA biosignature distinguishes spinal tuberculosis from other spinal destructive diseases and pulmonary tuberculosis

Frontiers in Cellular and Infection Microbiology, 2023
Accurate spinal tuberculosis (TB) diagnosis is of utmost importance for adequately treating and managing the disease. Given the need for additional diagnostic tools, this study aimed to investigate the utility of host serum miRNA biomarkers for ...
Qiang Liang, Qiang Liang, Weidong Jin, Zhigang Huang, Huquan Yin, Shengchun Liu, Liehua Liu, Xiangwei Song, Zili Wang, Zili Wang, Jun Fei   +10 more
doaj   +1 more source

Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria [PDF]

, 2016
Malaria remains one of the greatest public health challenges worldwide, particularly in sub-Saharan Africa. The clinical outcome of individuals infected with Plasmodium falciparum parasites depends on many factors including host systemic inflammatory ...
A Bhoumik, A Bhoumik, A Montecalvo, A Subtil, AK Bei, AT Argaw, C Barres, C Lamaze, C Lawrie, CJ Hemmer, CJ Murray, D Cifuentes, D Nantakomol, DM Patrick, DM Pegtel, DP Bartel, E Lau, E Macia, E Pongponratn, F Tabet, G Lv, G Meister, G Meister, GD Turner, GL Genrich, H Brown, H Valadi, J Baum, J Lu, J Skog, JD Arroyo, KC Vickers, KE Jackson, KM Schweitzer, KN Couper, L Song, LC Dore, LH Miller, M Bastiani, M Dreux, M Klemba, M Raab, M Trajkovski, M Zhan, MI Lin, MP Alves, MP Perron, N Regev-Rudzki, P Landry, P Pino, P Yin, PM Bauer, PY Mantel, R Jambou, R Martinelli, RM O'Connell, S Cheloufi, S Laurance, SY Chen, T Lopotova, UA Orom, V Boonpucknavig, V Combes, Y Lee, Y Zhang   +64 more
core   +1 more source

Integrated Analysis of lncRNA–miRNA–mRNA Regulatory Network in Rapamycin-Induced Cardioprotection against Ischemia/Reperfusion Injury in Diabetic Rabbits

Cells, 2023
The inhibition of mammalian target of rapamycin (mTOR) with rapamycin (RAPA) provides protection against myocardial ischemia/reperfusion (I/R) injury in diabetes.
Arun Samidurai, Amy L. Olex, Ramzi Ockaili, Donatas Kraskauskas, Sean K. Roh, Rakesh C. Kukreja, Anindita Das   +6 more
doaj   +1 more source

Signature of microRNA expression during osteogenic differentiation of bone marrow MSCs reveals a putative role of miR-335-5p in osteoarthritis [PDF]

, 2015
Background: The aim of this study was to evaluate, the existence of a signature of differentially expressed microRNAs (miRNAs) during osteogenic differentiation of bone marrow MSCs from OA and healthy donors and to describe their possible implication ...
Benjamín Fernández-Gutiérrez, Enrique Moro, Eva Herranz, Fernando Marco, José Ramón Lamas, Luis Rodríguez-Rodríguez, Lydia Abásolo, Manuel A. González, María Tomé, Pedro López-Romero, Pilar Tornero-Esteban   +10 more
core   +6 more sources

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Characteristics of binding sites of intergenic, intronic and exonic miRNAs with mRNAs of oncogenes coding intronic miRNAs [PDF]

, 2013
International audienceThe interaction of 784 intergenic (ig-miRNA), 686 intronic (in-miRNA) and 49 exonic miRNAs (ex-miRNA) with mRNAs of 51 oncogenes coding in-miRNAs was investigated.
Berillo, Olga, Issabekova, Assel, Ivashchenko, Anatoly, Regnier, Mireille   +3 more
core   +2 more sources

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

MicroRNA 181b regulates decorin production by dermal fibroblasts and may be a potential therapy for hypertrophic scar. [PDF]

PLoS ONE, 2015
Hypertrophic scarring is a frequent fibroproliferative complication following deep dermal burns leading to impaired function and lifelong disfigurement. Decorin reduces fibrosis and induces regeneration in many tissues, and is significantly downregulated
Peter Kwan, Jie Ding, Edward E Tredget
doaj   +1 more source