Functional role and epithelial to mesenchymal transition of the miR-590-3p/MDM2 axis in hepatocellular carcinoma [PDF]
BMC Cancer, 2023 Background There is considerable evidence that microRNAs (miRNAs) regulate several key tumor-associated genes/pathways and may themselves have a dual regulatory function either as tumor suppressors or oncogenic miRNA, depending on the tumor type ...
Alaa Ibrahem Youssef +2 more
doaj +2 more sources
Circ_0124644 Serves as a ceRNA for miR-590-3p to Promote Hypoxia-Induced Cardiomyocytes Injury via Regulating SOX4 [PDF]
Frontiers in Genetics, 2021 Circular RNA (circRNA) is an important factor for regulating the progression of many cardiovascular diseases, including acute myocardial infarction (AMI). However, the role of circ_0124644 in AMI progression remains unclear.
Juan Tan +7 more
doaj +2 more sources
MiR-590-3p affects the function of adipose-derived stem cells (ADSCs) on the survival of skin flaps by targeting VEGFA [PDF]
Regenerative Therapy, 2022 Introduction: Partial necrosis of skin flaps is still a substantial problem in plastic and reconstructive surgery. In this study, the role of miR-590-3p in adipose-derived stem cells (ADSCs) transplantation in improving the survival of skin flap in a ...
Kai Yang +7 more
doaj +2 more sources
Exosomal miR-590-3p derived from cancer-associated fibroblasts confers radioresistance in colorectal cancer [PDF]
Molecular Therapy: Nucleic Acids, 2021 Radiotherapeutic resistance is a major obstacle for the effective treatment of colorectal cancer (CRC). MicroRNAs (miRNAs) play a critical role in chemoresistance and radioresistance.
Xijuan Chen +7 more
doaj +2 more sources
Effect of LINC00657 on Apoptosis of Breast Cancer Cells by Regulating miR-590-3p [PDF]
Cancer Management and Research, 2020 Qiuli Shan,1 Fan Qu,1 Weiping Yang,2 Ningning Chen1 1College of Biological Science and Technology, University of Jinan, Jinan 250022, People’s Republic of China; 2Department of Thyroid Breast Surgery, Qingdao Chengyang People’s Hospital ...
Shan Q, Qu F, Yang W, Chen N
doaj +2 more sources
miR-590-3p and Its Downstream Target Genes in HCC Cell Lines [PDF]
Analytical Cellular Pathology, 2019 miRNAs are small non-coding RNA sequences of 18-25 nucleotides. They can regulate different cellular pathways by acting on tumor suppressors, oncogenes, or both.
Mennatallah Elfar, Asma Amleh
doaj +2 more sources
miR-590-3p Overexpression Improves the Efficacy of hiPSC-CMs for Myocardial Repair [PDF]
JACC: Basic to Translational ScienceSummary: Recent evidence demonstrates that low engraftment rates limit the efficacy of human induced pluripotent stem cell–derived cardiomyocytes (hiPSC-CMs) for cardiac repair after myocardial infarction.
Zhiwei Zhang, MD +7 more
doaj +2 more sources
Long Noncoding RNA Nuclear Paraspeckle Assembly Transcript 1 Promotes Progression and Angiogenesis of Esophageal Squamous Cell Carcinoma Through miR-590-3p/MDM2 Axis [PDF]
Frontiers in Oncology, 2021 Angiogenesis has been identified as one of the hallmarks of cancer and aggravates cancer development and progression. Accumulating evidence indicated that long noncoding RNAs (lncRNAs) are powerful factors in regulating various cancer behaviors.
Jing Luo +13 more
doaj +2 more sources
BMC Pulmonary Medicine, 2021 Background Non-small cell lung cancer (NSCLC) is one of the most prevalent cancers. As reported, long non-coding RNAs (lncRNAs) induce various biological behaviors in cancers.
Huanshun Wen +3 more
doaj +2 more sources
Long Noncoding RNA ZFAS1 Promotes Progression of NSCLC via Regulating of miR-590-3p [PDF]
Cell Transplantation, 2020 The incidence and mortality rate of nonsmall cell lung cancer (NSCLC) are continuously increasing. Recently, the important roles of long noncoding ribonucleic acid (lncRNA) zinc finger antisense1 (ZFAS1) in the development of many disease have been ...
Yumei Zhou +4 more
doaj +2 more sources