A statistically inferred microRNA network identifies breast cancer target miR-940 as an actin cytoskeleton regulator [PDF]
, 2015 International audienceMiRNAs are key regulators of gene expression. By binding to many genes, they create a complex network of gene co-regulation. Here, using a network-based approach, we identified miRNA hub groups by their close connections and common ...
Bhajun, Ricky +9 more
core +3 more sources
Unique, Gender-Dependent Serum microRNA Profile inPLS3 Gene-Related Osteoporosis [PDF]
, 2020 Plastin 3 (PLS3), encoded byPLS3, is a newly recognized regulator of bone metabolism, and mutations in the encoding gene result in severe childhood-onset osteoporosis.
Alice Costantini +11 more
core +1 more source
miR-590-3p Is a Novel MicroRNA in Myocarditis by Targeting Nuclear Factor Kappa-B in vivo
Cardiology, 2015 <b><i>Objective:</i></b> Nuclear factor kappa-B (NF-κB)-induced inflammation leads to myocarditis and heart dysfunction. How microRNAs (miRNAs) contribute to this process is poorly defined. The aim of this study was to investigate whether miRNAs regulate NF-κB-induced inflammation in experimental autoimmune ...
Xiao-Zhen Zhuo +11 more
openaire +3 more sources
Oxidative Stress and MicroRNAs in Endothelial Cells under Metabolic Disorders [PDF]
, 2023 Reactive oxygen species (ROS) are radical oxygen intermediates that serve as important second messengers in signal transduction. However, when the accumulation of these molecules exceeds the buffering capacity of antioxidant enzymes, oxidative stress and
Minjares, Morgan +2 more
core +1 more source
Profiling microRNAs in individuals at risk of progression to rheumatoid arthritis [PDF]
, 2017 Background: Individuals at risk of rheumatoid arthritis (RA) demonstrate systemic autoimmunity in the form of anti-citrullinated peptide antibodies (ACPA). MicroRNAs (miRNAs) are implicated in established RA.
AV Churov +28 more
core +2 more sources
Micro-RNA regulation of hepatic drug metabolism : age-related changes in micro-RNA expression and genetic variants in micro-RNA target sites [PDF]
, 2017 Indiana University-Purdue University Indianapolis (IUPUI)Developmental changes in the liver significantly impact drug disposition. Due to the emergence of microRNAs as important regulators of drug disposition, we hypothesize that age-dependent change
Burgess, Kimberly Sherrelle
core +1 more source
MIR205HG/LEADR Long Noncoding RNA Binds to Primed Proximal Regulatory Regions in Prostate Basal Cells Through a Triplex- and Alu-Mediated Mechanism [PDF]
, 2022 Aside serving as host gene for miR-205, MIR205HG transcribes for a chromatin-associated long noncoding RNA (lncRNA) able to restrain the differentiation of prostate basal cells, thus being reannotated as LEADR (Long Epithelial Alu-interacting ...
Bezzecchi, Eugenia +6 more
core +1 more source
The expression pattern of circulating miR-590-3p as a promising diagnostic biomarker for early detection of epithelial ovarian cancer [PDF]
, 2015 Epithelial ovarian cancer (EOC) is the most common type of ovarian tumors. The biomarkers, which are being used for EOC screening, have low sensitivity and specificity leading to late diagnosis and high mortality rate.
Shawer, Heba
core +1 more source
The Role of miR-590-3p in Regulating Human Epithelial Ovarian Cancer Development [PDF]
, 2019 Epithelial ovarian cancer (EOC) has the highest mortality rate among all gynecological malignancies. Early detection and intervention remain key to patient prognosis fueling the search for reliable biomarkers. MicroRNAs (miRNAs) are small non-coding RNAs
Salem, Mohamed
core
Novel integrative genomic tool for interrogating lithium response in bipolar disorder [PDF]
, 2015 We developed a novel integrative genomic tool called GRANITE (Genetic Regulatory Analysis of Networks Investigational Tool Environment) that can effectively analyze large complex data sets to generate interactive networks.
Alda, M +14 more
core +2 more sources