Results 11 to 20 of about 2,382 (118)

circ-TFRC downregulation suppresses ovarian cancer progression via miR-615-3p/IGF2 axis regulation [PDF]

Cancer Cell International
Background Ovarian cancer (OC) is a malignancy among female globally. Circular RNAs (circRNAs) are a family of circular endogenous RNAs generated from selective splicing, which take part in many traits.
Zhongxin Yan, Changling Duan, Xi Li, Hao Wang, Shanji Li, Xuexin Zhou, Yi Miao   +6 more
doaj   +4 more sources

HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis [PDF]

Nature Communications, 2018
The expression of telomerase catalytic subunit hTERT is frequently upregulated in many cancers. Here, the authors show HoxC5 and miR-615-3p can negatively regulate hTERT to impede tumorigenesis by targeting the newly evolved cis-regulatory genomic ...
TingDong Yan, Wen Fong Ooi, Aditi Qamra, Alice Cheung, DongLiang Ma, Gopinath Meenakshi Sundaram, Chang Xu, Manjie Xing, LaiFong Poon, Jing Wang, Yan Ping Loh, Jess Hui Jie Ho, Joscelyn Jun Quan Ng, Muhammad Khairul Ramlee, Luay Aswad, Steve G. Rozen, Sujoy Ghosh, Frederic A. Bard, Prabha Sampath, Vinay Tergaonkar, James O. J. Davies, Jim R. Hughes, Eyleen Goh, Xuezhi Bi, Melissa Jane Fullwood, Patrick Tan, Shang Li   +26 more
doaj   +6 more sources

Long non‐coding RNAFOXD1‐AS1 modulated CTCs epithelial‐mesenchymal transition and immune escape in hepatocellular carcinoma in vitro by sponging miR‐615‐3p [PDF]

Cancer Reports
Background Hepatocellular carcinoma (HCC) is widely recognized as a globally prevalent malignancy. Immunotherapy is a promising therapy for HCC patients. Increasing evidence suggests that lncRNAs are involved in HCC progression and immunotherapy. Aim The
Bao‐ling Guo, Qiu‐xiang Zheng, Yun‐shan Jiang, Ying Zhan, Wen‐jin Huang, Zhi‐yong Chen   +5 more
doaj   +4 more sources

Hypoxia-conditioned BMSC exosomes improve short-term spinal cord injury outcomes via the miR-615-3p/PDE4C-mediated cAMP/PKA pathway [PDF]

Stem Cell Research & Therapy
Spinal cord injury (SCI) remains a significant global health challenge with limited effective therapeutic options. Exosomes derived from mesenchymal stem cells (MSCs) have emerged as promising neuroprotective agents due to their biocompatibility and ...
Wei Bian, Xiangyu Zeng, Ziwen Liu, Mingyan Guan, Tegeleqi Bu, Haoze Li, Zewei Gao, Jianyu Liu   +7 more
doaj   +2 more sources

Upregulation of LINC01503 promotes cervical cancer progression by targeting the miR-615-3p/CCND1 axis. [PDF]

J Cancer, 2021
Mounting evidence indicates that long non-coding RNAs influence the progression of cervical cancer, but the precise function of LINC01503 in the pathogenesis of the disease remains unknown. Here, we found higher levels of LINC01503 in cervical cancer tissues.
Feng J, Gao FY, Li YY, Xiao XY, Xi J.
europepmc   +4 more sources

Small RNA Profiles of Serum-Derived Extracellular Vesicles in the Comorbid Condition of Frailty and Obstructive Pulmonary Disease: An Observational, Cross-Sectional Study [PDF]

Biomolecules
Frailty is increasingly recognized as a systemic complication in patients with obstructive pulmonary diseases (OPDs), yet its molecular basis remains unclear.
Keiko Doi, Tsunahiko Hirano, Naoomi Tominaga, Kenji Watanabe, Keiji Oishi, Ayumi Fukatsu-Chikumoto, Tasuku Yamamoto, Yuichi Ohteru, Kazuki Hamada, Yoriyuki Murata, Maki Asami-Noyama, Nobutaka Edakuni, Tomoyuki Kakugawa, Yoichi Mizukami, Kazuto Matsunaga   +14 more
doaj   +2 more sources

Personalizing Clozapine in Treatment-Resistant Schizophrenia: The Role of MicroRNA Biomarkers—A Pilot Study [PDF]

Current Issues in Molecular Biology
Background: Clozapine remains the only antipsychotic with proven efficacy in treatment-resistant schizophrenia (TRS). However, it is effective in only about 40% of patients and is associated with numerous adverse drug reactions.
Dmitry N. Sosin, Aiperi K. Khasanova, Roman A. Illarionov, Anastasia K. Popova, Karin B. Mirzaev, Andrey S. Glotov, Sergey N. Mosolov, Dmitry A. Sychev   +7 more
doaj   +2 more sources

MicroRNA transcriptome analysis reveals the potential role of miRNAs in regulating adipocyte hyperplasia and hypertrophy [PDF]

Frontiers in Genetics
BackgroundMicroRNAs (miRNAs) play a crucial role in regulating the development of backfat, yet their specific regulatory functions remain incompletely understood.
Ligang Ni, Zhanpeng Gu, Xiaoyan Wang, Junsheng Zhang, Chunbao Zhou, Yaqin Zhang, Huizhen Gao, Pan Xu   +7 more
doaj   +2 more sources

The Potential Tumor Promotional Role of circVAPA in Retinoblastoma via Regulating miR-615-3p and SMARCE1.

Onco Targets Ther, 2020
Growing evidence reveals that circular RNAs (circRNAs) play roles in cancer development. However, the effects and possible mechanisms of circRNAs in retinoblastoma (RB) are far from clear.circVAPA expression pattern was identified by RT-qPCR. circVAPA induced effects on RB cells were tested by CCK-8, clone forming, flow cytometry and transwell assays ...
Xu Q.
europepmc   +6 more sources

The Potential Tumor Promotional Role of circVAPA in Retinoblastoma via Regulating miR-615-3p and SMARCE1 [Retraction]. [PDF]

Onco Targets Ther, 2020
Xu Q. Onco Targets Ther. 2020;13:7839–7849. At the request of the author, the Editor and Publisher of OncoTargets and Therapy wish to retract the published article. The author contacted the journal after realising the Y79 cells had been mixed up with HEK-293T cells following a labelling error and the wrong ...
europepmc   +6 more sources