Results 21 to 30 of about 2,382 (118)

miR-615-3p expression level in bone marrow is associated with tumor recurrence in hepatocellular carcinoma. [PDF]

Mol Clin Oncol, 2015
The significance of disseminated tumor cells (DTCs) in bone marrow (BM) on tumor recurrence has not been investigated in patients with hepatocellular carcinoma (HCC). The aim of te present study was to clarify the molecular characteristics of DTCs that affect postoperative recurrence based on microRNA (miRNA) expression profiles in clinical HCC ...
Mukai R, Tomimaru Y, Nagano H, Eguchi H, Mimori K, Tomokuni A, Asaoka T, Wada H, Kawamoto K, Marubashi S, Doki Y, Mori M.   +11 more
europepmc   +4 more sources

Exploring vimentin's role in breast cancer via PICK1 alternative polyadenylation and the miR-615-3p-PICK1 interaction. [PDF]

Biofactors
Abstract Background: Breast cancer continues to be a major health issue for women worldwide, with Vimentin (VIM) identified as a crucial factor in its progression due to its role in cell migration and the epithelial-to-mesenchymal transition (EMT).
Jia X, Shao L, Quan H, Zhong Z, Dong C.
europepmc   +3 more sources

LncRNA HOXC-AS3 prevents chondrocyte senescence and osteoarthritis progression through miR-615-3p sponging and RRBP1 interaction. [PDF]

Cell Biosci
Abstract Background: Osteoarthritis (OA) is a prevalent chronic joint disease characterized by progressive cartilage degeneration, significantly impairing quality of life for millions worldwide. Cellular senescence has emerged as a pivotal driver of OA pathogenesis, with senescent chondrocytes exhibiting a senescence-associated secretory ...
Wang C, Zhou J, Chen L, Ma C, Dong Z, Miao D.   +5 more
europepmc   +2 more sources

MiRNA-615-3p Alleviates Oxidative Stress Injury of Human Cardiomyocytes Via PI3K/Akt Signaling by Targeting MEF2A

Anatolian Journal of Cardiology, 2022
Background: Myocardial infarction, a coronary heart disease, is a serious hazard to human health. Cardiomyocyte oxidative stress and apoptosis have been considered as the main causes of myocardial infarction. Here, we aimed to investigate the role of miR-
Dongying Zhang, Gang Zhang, Kun Yu, Xiwen Zhang, Aixia Jiang   +4 more
doaj   +1 more source

Understanding the Mechanisms of Human Liver Regeneration via Characterization of Circulating Extracellular Vesicles. [PDF]

Biomed Res Int
Aim Our study is aimed at identifying circulating extracellular vesicles associated with liver regeneration in humans and mice, exploring their roles, and evaluating their content as potential biomarkers of regeneration. Methods Plasma samples were collected from 12 human liver transplant recipients and 22 mice at distinct time points postsurgery ...
Sun Y, Pasini E, Nguyen-Lefebvre AT, Bhat M.   +3 more
europepmc   +2 more sources

A Combined microRNA and Chemokine Profile in Urine to Identify Rejection After Kidney Transplantation

Transplantation Direct, 2021
Background. There is an unmet need for noninvasive tools for diagnosis of rejection after kidney transplantation. The aim of this study was to determine the discriminative value of a combined cellular and molecular biomarker platform in urine for the ...
Els M. Gielis, MD, PhD, Jacqueline D.H. Anholts, BSc, Els van Beelen, BSc, Geert W. Haasnoot, BSc, Hans W. De Fijter, MD, PhD, Ingeborg Bajema, MD, PhD, Sebastiaan Heidt, PhD, Mathijs van de Vrie, MSc, Luuk B. Hilbrands, MD, PhD, Marko J.K. Mallat, MSc, Kristien J. Ledeganck, PhD, Frans H.J. Claas, PhD, Michael Eikmans, PhD   +12 more
doaj   +1 more source

RNA Regulatory Networks: Key Hubs in the Panorama of Cancer and Emerging Therapeutic Targets. [PDF]

MedComm (2020)
RNA regulatory networks play a crucial role in the initiation and progression of cancer through various modes of RNA interactions. Notably, circulating RNAs have emerged as potential biomarkers, while targeted interventions in RNA regulatory networks facilitate precise therapeutic strategies. ABSTRACT Cancer is a global health challenge. The initiation
Yin X, Du Z, Jiang S, Liao Y, Wang C, Li J, Zhang H, Wei TT, Zhang W, Zou Z.   +9 more
europepmc   +2 more sources

miR-615 Fine-Tunes Growth and Development and Has a Role in Cancer and in Neural Repair

Cells, 2020
MicroRNAs (miRNAs) are small noncoding RNAs that function as epigenetic modulators regulating almost any gene expression. Similarly, other noncoding RNAs, as well as epigenetic modifications, can regulate miRNAs. This reciprocal interaction forms a miRNA-
Marisol Godínez-Rubí, Daniel Ortuño-Sahagún   +1 more
doaj   +1 more source

Mouse microRNA signatures in joint ageing and post-traumatic osteoarthritis

Osteoarthritis and Cartilage Open, 2021
Objective: This study investigated mice serum and joint microRNA expression profiles in ageing and osteoarthritis to elucidate the role of microRNAs in the development and progression of disease, and provide biomarkers for ageing and osteoarthritis ...
Catarina I.G.D. Castanheira, James R. Anderson, Yongxiang Fang, Peter I. Milner, Katarzyna Goljanek-Whysall, Louise House, Peter D. Clegg, Mandy J. Peffers   +7 more
doaj   +1 more source

LncRNA HOTTIP promotes proliferation and inhibits apoptosis of gastric carcinoma cells via adsorbing miR-615-3p.

European review for medical and pharmacological sciences, 2020
To explore the role of long-noncoding ribonucleic acid HOXA transcript at the distal tip (lncRNA HOTTIP) in the proliferation and apoptosis of gastric carcinoma cells.The expressions of lncRNA HOTTIP in gastric carcinoma cell lines MGC-803, HGC-27, SNU-1, and SGC-7901 and normal gastric mucosa cell line RGM-1 were detected by real-time fluorescence ...
Xiao, Z.-S., Long, H., Zhao, L., Li, H.-X., Zhang, X.-N.   +4 more
openaire   +2 more sources