Results 31 to 40 of about 2,382 (118)

Application of Protein-Protein Interaction Network Analysis in Order to Identify Cervical Cancer miRNA and mRNA Biomarkers

open access: yesThe Scientific World Journal, 2023
Cervical cancer (CC) is one of the world’s most common and severe cancers. This cancer includes two histological types: squamous cell carcinoma (SCC) and adenocarcinoma (ADC). The current study aims at identifying novel potential candidate mRNA and miRNA
Parinaz Tabrizi-Nezhadi   +5 more
doaj   +1 more source

Deep Sequencing the MicroRNA Transcriptome in Colorectal Cancer. [PDF]

open access: yesPLoS ONE, 2013
Colorectal cancer (CRC) is one of the leading causes of cancer related deaths and the search for prognostic biomarkers that might improve treatment decisions is warranted.
Kristina Schee   +8 more
doaj   +1 more source

Elevated miR-615-3p Expression Predicts Adverse Clinical Outcome and Promotes Proliferation and Migration of Prostate Cancer Cells [PDF]

open access: yesThe American Journal of Pathology, 2019
miR-615-3p has previously been described as up-regulated in prostate cancer (PC) tissue samples compared with nonmalignant controls; however, its prognostic potential and functional role in PC remain largely unknown. In this study, we investigated the clinical and biological relevance of miR-615-3p in PC. The expression of miR-615-3p was measured in PC
Emma B. Laursen   +14 more
openaire   +5 more sources

MicroRNAs Regulate Cellular ATP Levels by Targeting Mitochondrial Energy Metabolism Genes during C2C12 Myoblast Differentiation. [PDF]

open access: yesPLoS ONE, 2015
In our previous study, we identified an miRNA regulatory network involved in energy metabolism in porcine muscle. To better understand the involvement of miRNAs in cellular ATP production and energy metabolism, here we used C2C12 myoblasts, in which ATP ...
Puntita Siengdee   +5 more
doaj   +1 more source

CircVAPA promotes proliferation and metastasis of retinoblastoma by modulating miR-615-3p and SMARCE1 [PDF]

open access: yes, 2020
Abstract Background Growing evidence reveals that circular RNAs (circRNAs) play roles in cancer development. However, the effects and possible mechanisms of circRNAs in retinoblastoma (RB) are far from clear. Methods circVAPA expression pattern was identified by RT-qPCR.
openaire   +1 more source

Identification of key miRNAs in prostate cancer progression based on miRNA-mRNA network construction

open access: yesComputational and Structural Biotechnology Journal, 2022
Prostate cancer (PC) is one of the major male cancers. Differential diagnosis of PC is indispensable for the individual therapy, i.e., Gleason score (GS) that describes the grade of cancer can be used to choose the appropriate therapy.
Giulia Dal Santo   +4 more
doaj   +1 more source

State of the Art of microRNAs Signatures as Biomarkers and Therapeutic Targets in Parkinson’s and Alzheimer’s Diseases: A Systematic Review and Meta-Analysis

open access: yesBiomedicines, 2023
Identifying target microRNAs (miRNAs) might serve as a basis for developing advanced therapies for Parkinson’s disease (PD) and Alzheimer’s disease. This review aims to identify the main therapeutic targets of miRNAs that can potentially act in Parkinson’
Idiberto José Zotarelli-Filho   +11 more
doaj   +1 more source

miRNAs expression signature potentially associated with lymphatic dissemination in locally advanced prostate cancer

open access: yesBMC Medical Genomics, 2020
Background Prostate cancer is one of the most common and socially significant cancers among men. The aim of our study was to reveal changes in miRNA expression profiles associated with lymphatic dissemination in prostate cancer and to identify the most ...
Elena A. Pudova   +18 more
doaj   +1 more source

Integrated small RNA, mRNA and protein omics reveal a miRNA network orchestrating metabolic maturation of the developing human heart

open access: yesBMC Genomics, 2023
Background As the fetal heart develops, cardiomyocyte proliferation potential decreases while fatty acid oxidative capacity increases in a highly regulated transition known as cardiac maturation.
Adar Aharon-Yariv   +3 more
doaj   +1 more source

Plasma Exosomes Transfer miR-885-3p Targeting the AKT/NFκB Signaling Pathway to Improve the Sensitivity of Intravenous Glucocorticoid Therapy Against Graves Ophthalmopathy

open access: yesFrontiers in Immunology, 2022
Graves ophthalmopathy (GO), a manifestation of Graves’ disease, is an organ-specific autoimmune disease. Intravenous glucocorticoid therapy (ivGCs) is the first-line treatment for moderate-to-severe and active GO.
Jingxue Sun   +8 more
doaj   +1 more source

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