Results 41 to 50 of about 2,382 (118)

HOTTIP downregulation reduces neuronal damage and microglial activation in Parkinson's disease cell and mouse models

Neural Regeneration Research, 2022
HOXA transcript at the distal tip (HOTTIP), a newly identified long noncoding RNA, has been shown to exhibit anti-inflammatory effects and inhibit oxygen-glucose deprivation-induced neuronal apoptosis.
Peng Lun, Tao Ji, De-Hong Wan, Xia Liu, Xiao-Dong Chen, Shuai Yu, Peng Sun   +6 more
doaj   +1 more source

Insights into the SARS-CoV-2-Mediated Alteration in the Stress Granule Protein Regulatory Networks in Humans

Pathogens, 2021
The rapidly and constantly evolving coronavirus, SARS-CoV-2, imposes a great threat to human health causing severe lung disease and significant mortality.
Kartikay Prasad, Abdullah F. Alasmari, Nemat Ali, Rehan Khan, Adel Alghamdi, Vijay Kumar   +5 more
doaj   +1 more source

LINC00657 played oncogenic roles in esophageal squamous cell carcinoma by targeting miR-615-3p and JunB

Biomedicine & Pharmacotherapy, 2018
The prognosis of esophageal squamous cell carcinoma (ESCC) is relatively poor due to the absence of efficient treatment. In this manuscript, we have investigated the specific roles and molecular mechanisms of LINC00657 to order to identify novel therapeutic targets for ESCC.The LINC00657 expression in ESCC tissues and cell lines were evaluated by ...
Yuchen Sun, Jizhao Wang, Shupei Pan, Tian Yang, Xuanzi Sun, Ya Wang, Xiaobo Shi, Xu Zhao, Jing Guo, Xiaozhi Zhang   +9 more
openaire   +2 more sources

Serum miRNA Profile in Diabetic Patients With Ischemic Heart Disease as a Promising Non-Invasive Biomarker

Frontiers in Endocrinology, 2022
The increasing morbidity and mortality of type 2 diabetic mellitus (T2DM) patients with ischemic heart disease (IHD) highlight an urgent need to identify early biomarkers, which would help to predict individual risk of development of IHD.
Agnieszka Bielska, Magdalena Niemira, Witold Bauer, Iwona Sidorkiewicz, Anna Szałkowska, Anna Skwarska, Justyna Raczkowska, Damian Ostrowski, Kamil Gugała, Sławomir Dobrzycki, Adam Krętowski, Adam Krętowski   +11 more
doaj   +1 more source

Comparative expression profiles of host circulating miRNAs in response to Trichinella spiralis infection

Veterinary Research, 2020
Trichinellosis is an important food-borne parasitic zoonosis throughout the world. At present, the mechanisms of Trichinella spiralis infection remain unclear. Acquiring detailed information on the host-Trichinella interaction would be beneficial for the
Xiao Han Ma, Hui Jun Ren, Ruo Yu Peng, Yi Li, Liang Ming   +4 more
doaj   +1 more source

MicroRNAs located in the Hox gene clusters are implicated in huntington's disease pathogenesis.

PLoS Genetics, 2014
Transcriptional dysregulation has long been recognized as central to the pathogenesis of Huntington's disease (HD). MicroRNAs (miRNAs) represent a major system of post-transcriptional regulation, by either preventing translational initiation or by ...
Andrew G Hoss, Vinay K Kartha, Xianjun Dong, Jeanne C Latourelle, Alexandra Dumitriu, Tiffany C Hadzi, Marcy E Macdonald, James F Gusella, Schahram Akbarian, Jiang-Fan Chen, Zhiping Weng, Richard H Myers   +11 more
doaj   +1 more source

Circulatory miRNA-484, 524, 615 and 628 expression profiling in HCV mediated HCC among Egyptian patients; implications for diagnosis and staging of hepatic cirrhosis and fibrosis

Journal of Advanced Research, 2020
Circulatory microRNAs have recently emerged as non-invasive and effective biomarkers for diagnosis of various diseases. Currently there is no reliable biomarker for diagnosis, prognosis or even staging of fibrotic and cirrhotic complications arising from
Shohda A. El-Maraghy, Ola Adel, Naglaa Zayed, Ayman Yosry, Saeed M. El-Nahaas, Abdullah A. Gibriel   +5 more
doaj   +1 more source

Exosome-derived circKIF20B suppresses gefitinib resistance and cell proliferation in non-small cell lung cancer

Cancer Cell International, 2023
Background The gefitinib resistance mechanism in non-small cell lung cancer (NSCLC) remains unclear, albeit exosomal circular RNA (circRNA) is known to possibly play a vital role in it.
Si-Liang Wei, Jing-Jing Ye, Li Sun, Lei Hu, Yuan-Yuan Wei, Da-Wei Zhang, Meng-Meng Xu, Guang-He Fei   +7 more
doaj   +1 more source

miR-615-3p promotes proliferation and migration and inhibits apoptosis through its potential target CELF2 in gastric cancer

Biomedicine & Pharmacotherapy, 2018
Gastric cancer incidence is relatively higher in China than that in developed countries; however, molecular mechanisms considering the initiation and progression of gastric cancer are still unclear. For decades, numerous microRNAs have been found to regulate a wide range of biological functions in gastric cancer.
Jizhao, Wang, Lin, Liu, Yuchen, Sun, Yumo, Xue, Jingkun, Qu, Shupei, Pan, Huajing, Li, Hangying, Qu, Jiansheng, Wang, Jia, Zhang   +9 more
openaire   +2 more sources

Immune non‐response despite effective antiretroviral therapy in people living with HIV: A review of potential mechanisms, biomarkers and therapeutic approaches

HIV Medicine, EarlyView.
Abstract Introduction A proportion of people living with HIV (PLWH) fail to restore their CD4 count or their CD4/CD8 ratio despite effective antiretroviral therapy (ART). PLWH with immune non‐response (INR) are at a higher risk of both AIDS and non‐AIDS events. The underlying mechanisms of INR remain unclear.
Charlotte Silvestre, Antoine Gross, Alain Makinson   +2 more
wiley   +1 more source