Results 11 to 20 of about 2,436 (103)

circPUM1 Promotes Tumorigenesis and Progression of Ovarian Cancer by Sponging miR-615-5p and miR-6753-5p [PDF]

Molecular Therapy: Nucleic Acids, 2019
Circular RNAs (circRNAs) have been reported to participate in the molecular mechanism of human cancers. The PUM1 gene has been confirmed to be closely related to tumorigenesis and progression of ovarian cancer.
Xue Guan, Zhi-hong Zong, Yao Liu, Shuo Chen, Li-li Wang, Yang Zhao   +5 more
doaj   +5 more sources

Circ‐PITX1 promotes non‐small‐cell lung cancer progression through regulating ETS1 expression via miR‐615‐5p [PDF]

Thoracic Cancer
Background Circular RNAs (circRNAs), produced by reverse splicing, act as important players in human cancers. We aimed to assess the biological functions of circRNA pituitary homeobox 1 (circ‐PITX1) in non‐small‐cell lung cancer (NSCLC).
Yang Guo, Jianfang Pan, Xiaofei Gao, Yan Zheng   +3 more
doaj   +4 more sources

Circular RNA 100146 functions as an oncogene through direct binding to miR-361-3p and miR-615-5p in non-small cell lung cancer [PDF]

Molecular Cancer, 2019
Circular RNAs are widely expressed in eukaryotic cells and associated with cancer. However, limited studies to date have focused on the potential role of circRNAs in progression of lung cancer.
Lijian Chen, Aruo Nan, Nan Zhang, Yangyang Jia, Xin Li, Yihui Ling, Jiabin Dai, Shaozhu Zhang, Qiaoyuan Yang, Yanni Yi, Yiguo Jiang   +10 more
doaj   +4 more sources

Hsa_circRNA_002144 promotes growth and metastasis of colorectal cancer through regulating miR-615-5p/LARP1/mTOR pathway. [PDF]

Carcinogenesis, 2021
AbstractCircRNAs (circular RNAs), recently identified as a critical regulator in tumorigenesis, participate in CRC (colorectal cancer) growth. However, the role of hsa_circRNA_002144 in CRC was poorly understood. Firstly, hsa_circRNA_002144 showed significantly elevation in both of CRC tissues and cell lines, and suggested closely associated with poor ...
Wu M, Kong C, Cai M, Huang W, Chen Y, Wang B, Liu X.   +6 more
europepmc   +4 more sources

Circular RNA hsa_circ_0004396 acts as a sponge of miR-615-5p to promote non-small cell lung cancer progression and radioresistance through the upregulation of P21-Activated Kinase 1. [PDF]

J Clin Lab Anal, 2022
AbstractBackgroundsCircRNA hsa_circ_0004396 has been confirmed to be upregulated in human non‐small cell lung cancer (NSCLC). The aim of his study was to evaluate its mechanism in the radioresistance and progression of NSCLC.MethodsHsa_circ_0004396, miR‐615‐5p, and P21‐Activated Kinase 1 (PAK1) were measured by reverse transcription quantitative real ...
Li D, Yan L, Zhang J, Gu F.
europepmc   +3 more sources

lncRNA Gm15290 promotes cell proliferation and invasion in lung cancer through directly interacting with and suppressing the tumor suppressor miR-615-5p. [PDF]

Biosci Rep, 2018
Long non-coding RNAs (lncRNAs) have been involved in occurrence and progression of multiple cancers. In the present study, we investigated the role of lncRNA Gm15290 in the proliferation and invasion of non-small cell lung cancer (NSCLC) cells. First, we found that lncRNA Gm15290 was markedly up-regulated in tumor tissues from NSCLC patients and NSCLC ...
Dong Y, Huo X, Sun R, Liu Z, Huang M, Yang S.   +5 more
europepmc   +4 more sources

Personalizing Clozapine in Treatment-Resistant Schizophrenia: The Role of MicroRNA Biomarkers—A Pilot Study [PDF]

Current Issues in Molecular Biology
Background: Clozapine remains the only antipsychotic with proven efficacy in treatment-resistant schizophrenia (TRS). However, it is effective in only about 40% of patients and is associated with numerous adverse drug reactions.
Dmitry N. Sosin, Aiperi K. Khasanova, Roman A. Illarionov, Anastasia K. Popova, Karin B. Mirzaev, Andrey S. Glotov, Sergey N. Mosolov, Dmitry A. Sychev   +7 more
doaj   +2 more sources

Small RNA Profiles of Serum-Derived Extracellular Vesicles in the Comorbid Condition of Frailty and Obstructive Pulmonary Disease: An Observational, Cross-Sectional Study [PDF]

Biomolecules
Frailty is increasingly recognized as a systemic complication in patients with obstructive pulmonary diseases (OPDs), yet its molecular basis remains unclear.
Keiko Doi, Tsunahiko Hirano, Naoomi Tominaga, Kenji Watanabe, Keiji Oishi, Ayumi Fukatsu-Chikumoto, Tasuku Yamamoto, Yuichi Ohteru, Kazuki Hamada, Yoriyuki Murata, Maki Asami-Noyama, Nobutaka Edakuni, Tomoyuki Kakugawa, Yoichi Mizukami, Kazuto Matsunaga   +14 more
doaj   +2 more sources

Cancer-associated fibroblast-derived circKLHL24 drives perineural invasion in pancreatic cancer via dual regulation of the sec31a-CXCL12 axis [PDF]

Journal of Experimental & Clinical Cancer Research
Background Cancer-associated fibroblasts (CAFs) are key drivers of neural invasion in pancreatic cancer, yet their regulatory mechanisms remain elusive.This study explores the role of circular RNAs (circRNAs) in CAFs and their involvement in regulating ...
Tingting Li, Rihua He, Qing Tian, Tianhao Huang, Honghui Jiang, Huimou Chen, Yuan Yuan, Yong Jiang, Shangyou Zheng, Chonghui Hu, Shizong Li, Guolin Li, Rufu Chen   +12 more
doaj   +2 more sources

MicroRNA transcriptome analysis reveals the potential role of miRNAs in regulating adipocyte hyperplasia and hypertrophy [PDF]

Frontiers in Genetics
BackgroundMicroRNAs (miRNAs) play a crucial role in regulating the development of backfat, yet their specific regulatory functions remain incompletely understood.
Ligang Ni, Zhanpeng Gu, Xiaoyan Wang, Junsheng Zhang, Chunbao Zhou, Yaqin Zhang, Huizhen Gao, Pan Xu   +7 more
doaj   +2 more sources