Results 21 to 30 of about 2,436 (103)

MiRNA-615-5p functions as a tumor suppressor in pancreatic ductal adenocarcinoma by targeting AKT2. [PDF]

PLoS ONE, 2015
BACKGROUND:Aberrant microRNA (miRNA) expression is associated with tumor development. This study aimed to elucidate the role of miR-615-5p in the development of pancreatic ductal adenocarcinoma (PDAC).
Yang Sun, Tingting Zhang, Cuiping Wang, Xianglan Jin, Congwei Jia, Shuangni Yu, Jie Chen   +6 more
doaj   +1 more source

Regulation of lipid droplet (LD) formation in hepatocytes via regulation of SREBP1c by non-coding RNAs

Frontiers in Medicine, 2022
IntroductionIncreased de novo lipogenesis (DNL) is one of the key factors contributing to fat accumulation and non-alcoholic fatty liver disease (NAFLD).
Shereen A. El Sobky, Nourhan K. Aboud, Nihal M. El Assaly, Injie O. Fawzy, Nada El-Ekiaby, Ahmed I. Abdelaziz   +5 more
doaj   +1 more source

miR-615-5p is epigenetically inactivated and functions as a tumor suppressor in pancreatic ductal adenocarcinoma [PDF]

Oncogene, 2014
Pancreatic ductal adenocarcinoma (PDAC) is a highly invasive cancer with a poor prognosis. Although microRNA (miRNA) transcripts have a crucial role in carcinogenesis and development, little information is known regarding the aberrant DNA methylation of miRNAs in PDAC. Using methylated DNA immunoprecipitation-chip analysis, we found that miR-615-5p was
W, Gao, Y, Gu, Z, Li, H, Cai, Q, Peng, M, Tu, Y, Kondo, K, Shinjo, Y, Zhu, J, Zhang, Y, Sekido, B, Han, Z, Qian, Y, Miao   +13 more
openaire   +2 more sources

Ssc-MiR-21-5p and Ssc-MiR-615 Regulates the Proliferation and Apoptosis of Leydig Cells by Targeting SOX5

Cells, 2022
Leydig cells (LCs) are the predominant cells of androgen production, which plays key roles in spermatogenesis and maintaining male secondary sexual characteristics.
Qi Tang, Yanghai Zhang, Linxiu Yue, Hongying Ren, Chuanying Pan   +4 more
doaj   +1 more source

A Combined microRNA and Chemokine Profile in Urine to Identify Rejection After Kidney Transplantation

Transplantation Direct, 2021
Background. There is an unmet need for noninvasive tools for diagnosis of rejection after kidney transplantation. The aim of this study was to determine the discriminative value of a combined cellular and molecular biomarker platform in urine for the ...
Els M. Gielis, MD, PhD, Jacqueline D.H. Anholts, BSc, Els van Beelen, BSc, Geert W. Haasnoot, BSc, Hans W. De Fijter, MD, PhD, Ingeborg Bajema, MD, PhD, Sebastiaan Heidt, PhD, Mathijs van de Vrie, MSc, Luuk B. Hilbrands, MD, PhD, Marko J.K. Mallat, MSc, Kristien J. Ledeganck, PhD, Frans H.J. Claas, PhD, Michael Eikmans, PhD   +12 more
doaj   +1 more source

Iodine-125 seed represses the growth and facilitates the apoptosis of colorectal cancer cells by suppressing the methylation of miR-615 promoter

BMC Cancer, 2022
Background Colorectal cancer (CRC) represents a common malignancy in gastrointestinal tract. Iodine-125 (125I) seed implantation is an emerging treatment technology for unresectable tumors.
Fenghai Ren, Baojun Li, Chao Wang, Yanbo Wang, Binbin Cui   +4 more
doaj   +1 more source

Mouse microRNA signatures in joint ageing and post-traumatic osteoarthritis

Osteoarthritis and Cartilage Open, 2021
Objective: This study investigated mice serum and joint microRNA expression profiles in ageing and osteoarthritis to elucidate the role of microRNAs in the development and progression of disease, and provide biomarkers for ageing and osteoarthritis ...
Catarina I.G.D. Castanheira, James R. Anderson, Yongxiang Fang, Peter I. Milner, Katarzyna Goljanek-Whysall, Louise House, Peter D. Clegg, Mandy J. Peffers   +7 more
doaj   +1 more source

miR-615 Fine-Tunes Growth and Development and Has a Role in Cancer and in Neural Repair

Cells, 2020
MicroRNAs (miRNAs) are small noncoding RNAs that function as epigenetic modulators regulating almost any gene expression. Similarly, other noncoding RNAs, as well as epigenetic modifications, can regulate miRNAs. This reciprocal interaction forms a miRNA-
Marisol Godínez-Rubí, Daniel Ortuño-Sahagún   +1 more
doaj   +1 more source

Mmu-miR-615-3p regulates lipoapoptosis by inhibiting C/EBP homologous protein. [PDF]

PLoS ONE, 2014
Lipoapoptosis occurring due to an excess of saturated free fatty acids such as palmitate is a key pathogenic event in the initiation of nonalcoholic fatty liver disease.
Yasuhiro Miyamoto, Amy S Mauer, Swarup Kumar, Justin L Mott, Harmeet Malhi   +4 more
doaj   +1 more source

CDX2 inhibits pancreatic adenocarcinoma cell proliferation via promoting tumor suppressor miR-615-5p

Tumor Biology, 2015
CDX2 has recently been identified as a prognostic marker for pancreatic adenocarcinoma. However, the role and mechanism of CDX2 in progression of pancreatic adenocarcinoma are still elusive. In this study, we observed that CDX2 expression was much lower in mouse pancreatic adenocarcinoma tissues and pancreatic cancer cells.
Yuanyuan, Jiang, Yan, Zhang, Fuqing, Li, Xiaolin, Du, Jinping, Zhang   +4 more
openaire   +2 more sources