Results 41 to 50 of about 2,436 (103)

Identification of key miRNAs in prostate cancer progression based on miRNA-mRNA network construction

open access: yesComputational and Structural Biotechnology Journal, 2022
Prostate cancer (PC) is one of the major male cancers. Differential diagnosis of PC is indispensable for the individual therapy, i.e., Gleason score (GS) that describes the grade of cancer can be used to choose the appropriate therapy.
Giulia Dal Santo   +4 more
doaj   +1 more source

miR-615-5p prevents proliferation and migration through negatively regulating serine hydromethyltransferase 2 (SHMT2) in hepatocellular carcinoma

open access: yesTumor Biology, 2015
It has been reported that miR-615-5p was upregulated in hepatocellular carcinoma (HCC) preventing both growth and migration. However, the underlying mechanism by which miR-615-5p played a role in HCC remains unknown. Here, in our present study, to investigate the mechanism of miR-615-5p, bioinformatic prediction and luciferase reporter assay were ...
Xiaoyu, Wu   +6 more
openaire   +2 more sources

Microarray data analysis on gene and miRNA expression to identify biomarkers in non-small cell lung cancer

open access: yesBMC Cancer, 2020
Background The aim of this study was to gain further investigation of non-small cell lung cancer (NSCLC) tumorigenesis and identify biomarkers for clinical management of patients through comprehensive bioinformatics analysis.
Xiang Jin   +3 more
doaj   +1 more source

Comparative expression profiles of host circulating miRNAs in response to Trichinella spiralis infection

open access: yesVeterinary Research, 2020
Trichinellosis is an important food-borne parasitic zoonosis throughout the world. At present, the mechanisms of Trichinella spiralis infection remain unclear. Acquiring detailed information on the host-Trichinella interaction would be beneficial for the
Xiao Han Ma   +4 more
doaj   +1 more source

The glycosyltransferase ST3GAL2 is regulated by miR-615-3p in the intestinal tract of Campylobacter jejuni infected mice

open access: yesGut Pathogens, 2021
Background Campylobacter jejuni (C. jejuni) infections are of increasing importance worldwide. As a typical mucosal pathogen, the interaction of C. jejuni with mucins is a prominent step in the colonisation of mucosal surfaces. Despite recent advances in
De Xi   +7 more
doaj   +1 more source

Cadmium promotes apoptosis and inflammation via the circ08409/miR-133a/TGFB2 axis in bovine mammary epithelial cells and mouse mammary gland

open access: yesEcotoxicology and Environmental Safety, 2021
Cadmium is a common environmental heavy metal pollutant that can accumulate over long periods of time and cause disease. Thus, analysis of the molecular mechanisms affected by cadmium in the body could be of great significance for the prevention and ...
Zhi Chen   +7 more
doaj   +1 more source

Circ_0062020 Knockdown Strengthens the Radiosensitivity of Prostate Cancer Cells

open access: yesCancer Management and Research, 2020
Haitao Li,* Yunlai Zhi,* Chunyan Ma, Qianqian Shen, Fanghu Sun, Chengkuan Cai Department of Urology, Lianyungang Clinical College of Nanjing Medical University/The First People’s Hospital of Lianyungang, Lianyungang, Jiangsu, People’s ...
Li H, Zhi Y, Ma C, Shen Q, Sun F, Cai C
doaj  

Integrated small RNA, mRNA and protein omics reveal a miRNA network orchestrating metabolic maturation of the developing human heart

open access: yesBMC Genomics, 2023
Background As the fetal heart develops, cardiomyocyte proliferation potential decreases while fatty acid oxidative capacity increases in a highly regulated transition known as cardiac maturation.
Adar Aharon-Yariv   +3 more
doaj   +1 more source

miR-125a-5p regulates the sialyltransferase ST3GAL1 in murine model of human intestinal campylobacteriosis

open access: yesGut Pathogens, 2023
Background Zoonotic microorganisms are increasingly impacting human health worldwide. Due to the development of the global population, humans and animals live in shared and progressively crowded ecosystems, which enhances the risk of zoonoses.
Angelina Kraski   +7 more
doaj   +1 more source

Serum miRNA Profile in Diabetic Patients With Ischemic Heart Disease as a Promising Non-Invasive Biomarker

open access: yesFrontiers in Endocrinology, 2022
The increasing morbidity and mortality of type 2 diabetic mellitus (T2DM) patients with ischemic heart disease (IHD) highlight an urgent need to identify early biomarkers, which would help to predict individual risk of development of IHD.
Agnieszka Bielska   +11 more
doaj   +1 more source

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