Results 81 to 90 of about 6,232 (244)

A miR-335/COX-2/PTEN axis regulates the secretory phenotype of senescent cancer-associated fibroblasts [PDF]

, 2016
AGING applies the Creative Commons Attribution License (CCAL) to all works we publishWe acknowledge the financial support of the University of Sheffield, The Pathological Society London, The University of Otago-Dunedin and the Development and Promotion ...
Abbadie, Benetti, Berger, Bernad, Campisi, Campisi, Campisi, Chen, Chen, Dubinett, Fan, Felley-Bosco, Ho, Ittmann, Joel, Joyce, Lamas, Lambert, Lefaix, Li, Liu, Lowe, McCance, Mi, Murdoch, Neel, Nelson, Ostrowski, Parkinson, Partridge, Pecot, Peters-Golden, Prime, Prime, Qiu, Reisfeld, Scully, Takeyama, Teng, Thorin, Toews, Vaheri, White, You   +43 more
core   +3 more sources

A MicroRNA Next-Generation-Sequencing Discovery Assay (miND) for Genome-Scale Analysis and Absolute Quantitation of Circulating MicroRNA Biomarkers [PDF]

, 2022
The plasma levels of tissue-specific microRNAs can be used as diagnostic, disease severity and prognostic biomarkers for chronic and acute diseases and drug-induced injury.
Buchtele, Nina, Diendorfer, Andreas B, Fournier, Catharine Aquino, Frank, Bernhard J H, Glaab, Warren E, Goldring, Christopher E, Grillari, Johannes, Grillari, Regina, Hackl, Matthias, Hofstaetter, Jochen G, Jilma, Bernd, Khamina, Kseniya, Krammer, Teresa L, Otto, Carolin, Pultar, Marianne, Rehrauer, Hubert, Ruprecht, Klemens, Schoergenhofer, Christian, Schofield, Amy L, Skalicky, Susanna, Smith, Aaron Thomas, Weigl, Moritz   +21 more
core   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Colorectal cancer: from the genetic model to posttranscriptional regulation by noncoding RNAs [PDF]

, 2017
Colorectal cancer is the third most common form of cancer in developed countries and, despite the improvements achieved in its treatment options, remains as one of the main causes of cancer-related death.
Calle Espinosa, Jorge, Fernández Lizarbe, Eva, Fernández Lizarbe, Sara, Lizarbe, María Antonia, Olmo López, Nieves, Robles, Miguel Ángel, Turnay, Javier   +6 more
core   +4 more sources

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Feasibility and Tolerability of Performing Portable MRI for Neurological Disorders in an Outpatient Neurology Clinic: A Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick, Nomin Enkhtsetseg, Joseph Sadok, Matheus Mochetti, Annabel Sorby Adams, Jennifer Guo, Cristina Trapaga Hacker, Isabella Gomez Hjerthen, Seungwon Lee, Siddharth Satish, Andrew S. Ham, Justin Hill, Denis Balaban, Kevin Kyle, Rebecca L. Gillani, Marcelo Matiello, Aleksandar Videnovic, Eric C. Klawiter, W. Taylor Kimberly, Farrah J. Mateen   +19 more
wiley   +1 more source

Noncoding RNAs as Predictive Biomarkers of Therapeutic Response to Tyrosine Kinase Inhibitors in Metastatic Cancer [PDF]

, 2019
Since their discovery, noncoding RNAs have acquired extensive attention due to their eminent role in the regulation of gene expression and thus also in the pathogenesis of many diseases.
Kovacova, Julia, Slaby, Ondrej
core   +2 more sources

Identification of a miR-146b-FasL axis in the development of neutropenia in T large granular lymphocyte leukemia [PDF]

, 2020
T Large Granular Lymphocytes leukemia is characterized by the expansion of several Large Granular Lymphocyte clones, among which a subset of Large Granular Lymphocytes showing constitutively activated STAT3, a specific CD8+/CD4- phenotype and the ...
Baril\ue0, Gregorio, BAZZONI, FLAVIA, Calabretto, Giulia, Castellucci, Monica, Facco, Monica, Leoncin, Matteo, Mariotti, Barbara, Rossato, Marzia, Semenzato, Gianpietro, Teramo, Antonella, Vicenzetto, Cristina, Zambello, Renato   +11 more
core   +3 more sources

Clinical Outcomes of Patients Within the Rheumatoid Arthritis Care Pathway Cohort at a Tertiary Care Integrated Delivery Network: A Comparison to Usual Care

Arthritis Care &Research, EarlyView.
Objective We aimed to compare clinical outcomes between patients in the Allegheny Health Network rheumatoid arthritis (RA) care pathway and patients receiving usual care. Methods The care pathway initiative implements guideline‐based best practice alongside multidisciplinary team‐based care.
Tarun Sharma, Tyson S. Barrett, Teigan Dwyer, Nancy Campbell, Jessica Heintzinger, Ellen Kraemer, Adam Dore, Susan Manzi   +7 more
wiley   +1 more source

Evaluation of a Novel Electric Health Record Sidecar Application to Display Rheumatoid Arthritis Clinical Outcomes During Clinic Visits: Results of a Stepped‐Wedge Cluster Randomized Pragmatic Trial

Arthritis Care &Research, EarlyView.
Objective We developed a novel electronic health record sidecar application to visualize key rheumatoid arthritis (RA) outcomes, including disease activity, physical function, and pain, via a patient‐facing graphical interface designed for use during outpatient visits (“RA PRO dashboard”).
Gabriela Schmajuk, Jing Li, Cathy Nasrallah, Cherish Wilson, Alicia Hamblin, Christine Hariz, Cammie Young, Stephen Shiboski, Emma Kersey, Mary Nakamura, Judith F. Ashouri, Mehrdad Matloubian, Andrew J. Gross, Jennifer Barton, Beth Berrean, Jonathan Prugh, Jinoos Yazdany   +16 more
wiley   +1 more source