Results 61 to 70 of about 214,976 (242)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Journal of Translational Medicine, 2023 Background ND630 is believed to be a new therapy pharmacologic molecule in targeting the expression of ACACA and regulating the lipid metabolism. However, the function of ND630 in prostate cancer remains unknown.
Yu-Peng Wu +10 more
doaj +1 more source
TP53RK and BCL2L2 suppress the effects of miR-630 overexpression.
, 2015 (A) TP53RK or BCL2L2 protein caused a significantly decreased IR-induced inhibition rate in miR-630 transfected cell lines. (B and C) TP53RK or BCL2L2 protein decreased the fold of caspase 3 and caspase 6 activities following IR exposure in miR-630 ...
Guoxin Li (291236) +6 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Bioinformatic analysis of the ssc-miR-146b upstream promoter region
Animal Nutrition, 2015 Sus Scrofa microRNA-146b-5p (ssc-miR-146b) was found to be one of differentially expressional microRNAs (miRNA) in our previous study. Not only it is highly expressed but also it maintains the largest up-regulated differences on the expressional level at
Xin Tao, Xiaoming Men, Ziwei Xu
doaj +1 more source
, 2013 (A) pre-miR-630 expression in PANC-1 and MiaPaCa-2 cells. (B and C) Increased expression of pre-miR-630 decreased IGF-1R mRNA but not Cdc14A in cells. (D). Decreased IGF-1R protein expression in pre-miR-630 expressed cells.
Arun K. Rishi (141564) +5 more
core +1 more source
Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito +14 more
wiley +1 more source
Scientific Reports, 2020 Despite the use of antiretroviral therapy (ART) in HIV-1 infected mothers approximately 5% of new HIV-1 infections still occur in breastfed infants annually, which warrants for the development of novel strategies to prevent new HIV-1 infections in ...
Muhammad Atif Zahoor +6 more
doaj +1 more source
Exogenous expression of miR-630 inhibits the growth of PC-3 cells.
, 2014 A, confirmation by qRT-PCR of the successful overexpression of exogenous miR-630 from the pEP-hsa-miR-630 expression vector in PC-3 cells. The data are represented as the mean ± SEM of n = 3 independent experiments.
Takao Inoue (244518) +11 more
core +1 more source